ID D2H8W4_AILME Unreviewed; 1374 AA.
AC D2H8W4;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 24-JAN-2024, entry version 69.
DE RecName: Full=Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 {ECO:0000256|ARBA:ARBA00016171};
DE AltName: Full=Membrane-associated guanylate kinase inverted 3 {ECO:0000256|ARBA:ARBA00033438};
DE Flags: Fragment;
GN ORFNames=PANDA_006721 {ECO:0000313|EMBL:EFB15067.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB15067.1};
RN [1] {ECO:0000313|EMBL:EFB15067.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the MAGUK family.
CC {ECO:0000256|ARBA:ARBA00007014}.
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DR EMBL; GL192586; EFB15067.1; -; Genomic_DNA.
DR HOGENOM; CLU_004562_1_0_1; -.
DR InParanoid; D2H8W4; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 5.
DR CDD; cd00201; WW; 2.
DR Gene3D; 2.20.70.10; -; 2.
DR Gene3D; 2.30.42.10; -; 5.
DR Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR10316; MEMBRANE ASSOCIATED GUANYLATE KINASE-RELATED; 1.
DR PANTHER; PTHR10316:SF10; MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF16663; MAGI_u1; 1.
DR Pfam; PF00595; PDZ; 4.
DR Pfam; PF00397; WW; 2.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 5.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 5.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 5.
DR PROSITE; PS01159; WW_DOMAIN_1; 2.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 9..85
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT DOMAIN 188..221
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 234..267
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 305..373
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 473..536
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 621..703
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 746..833
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 916..998
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 77..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 265..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 441..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 833..889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1057..1374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..130
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..160
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..467
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 840..865
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1057..1084
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1085..1117
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1140..1154
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1212..1261
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1270..1334
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EFB15067.1"
FT NON_TER 1374
FT /evidence="ECO:0000313|EMBL:EFB15067.1"
SQ SEQUENCE 1374 AA; 150335 MW; 9F255C0B97188F46 CRC64;
GKVINKDLRH YLSLQFQKGS IDHKLQQVIR DNLYLRTIPC TTRAPRDGEV PGVDYNFISV
EQFKALEESG ALLESGTYDG NFYGTPKPPA EPSPFQPDPV DQVLFDNEFD TESQRKRTTS
VSKMERMDSS LPEEEEDEDK EAVNGSGTAE NRERHSESSD WIKTIPSYNQ TNSSMDFRNY
MMRDENLEPL PKNWEMAYTD TGLVYFIDHN TKTTTWLDPR LCKKAKAPED CEDGELPYGW
EKIEDPQYGT YYVDHLNQKT QFENPVEEAK RKKQLGQAET GSSKADMEKS HFTRDPSQLK
GILIRASLKK STMGFGFTII GGDRPDEFLQ VKNVLKDGPA AQDGKIAPGD VIVDINGNCV
LGHTHADVVQ MFQLVPVNQY VSLTLCRGYP LPDDSEDSVA DIVAATPVIN GQSLTKGETC
MNTQDFKSGA VVLDQNGKPG PTLISDRLNG PSDLSEQRAS LASSGGSQPE LVTIPLMKGP
KGFGFAIADS PAGQKVKMIL DSQWCQGLQK GDIIKEIYHQ NVQSLTHLQV VEVLKQFPVG
ADVPLLILRG GPPSPTKTAK MKTDKKENSG SLEAINEPIP QPMPFPPSIV RSGSPKLDPS
EVYLKSKTLY EDKPPNTKDL DVFLRKQESG FGFRVLGGEG PDQSIYIGAI IPLGAAERDG
RLRAADELMC IDGIPVKGKS HKQVLDLMTT AARNGHVLLT VRRKIFYGEK QPEEDSSQAF
LSTQNGSPRL TRAELPARPA LQEAYDVLLQ RKENEGFGFV ILTSKSKPPP GVIPHKIGRV
IEGSPADRCG KLKIGDHISA VNGQSIVELS HDNIVQLIKD AGVTVTLTVV AEEEHHGPPS
GTNSARQSPA LQHRPMGQSQ PNHIPGDRSA LEGEIGKDGS TSYRHSWSDH KHLAQPDTAM
ISVVGTRHNQ SLGCYPVELE RGPRGFGFSL RGGKEYNMGL FILRLAEEGP AIKDGRIHVG
DQIVEINGEP TQGITHTRAI ELIQAGGNKV LLLLRPGTGL IPDHGDRDVN PASSNVIYDE
LPPFPPSSHS ASVLEGSPVP VTEESFMRVQ ICEKTEELKD GVPEKKSTLN ENPSDKKHSF
LQKNVNKRDP PSSQGQSDKK NPFRVENGVT QRGRSVSPRK PTGRHAEGPS DQLPSPLPAD
PKRRPRDRSL SPRKGDSKGG QMGTRAGSGQ DHCGRSRGWS SSPKKQQKTE GSKGRSNAEA
RLLGAESQRG GGRAKDGAEQ ISEGREESGV VRKDTKQSQS GKNRTRSPEK KSKRMDDKSL
PSKKTSTAAS RVLSDREKGK KATLGETSSS KEKTGENART SDKKLKQDPE ERTVLNKIQA
PRGKEQEAAD RSRESGGFQP ESASPVKKTP ITPGPWKVPS ANKAAGTTGV AEKR
//
