ID D2H9M7_AILME Unreviewed; 524 AA.
AC D2H9M7;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 24-JAN-2024, entry version 51.
DE RecName: Full=Cochlin {ECO:0000256|ARBA:ARBA00013828};
DE Flags: Fragment;
GN ORFNames=PANDA_007041 {ECO:0000313|EMBL:EFB13216.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB13216.1};
RN [1] {ECO:0000313|EMBL:EFB13216.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
CC -!- FUNCTION: Plays a role in the control of cell shape and motility in the
CC trabecular meshwork. {ECO:0000256|ARBA:ARBA00003388}.
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DR EMBL; GL192604; EFB13216.1; -; Genomic_DNA.
DR AlphaFoldDB; D2H9M7; -.
DR InParanoid; D2H9M7; -.
DR CDD; cd01472; vWA_collagen; 1.
DR CDD; cd01482; vWA_collagen_alphaI-XII-like; 1.
DR Gene3D; 2.170.130.20; LCCL-like domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 2.
DR InterPro; IPR004043; LCCL.
DR InterPro; IPR036609; LCCL_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR24020:SF36; COCHLIN; 1.
DR PANTHER; PTHR24020; COLLAGEN ALPHA; 1.
DR Pfam; PF03815; LCCL; 1.
DR Pfam; PF00092; VWA; 2.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00603; LCCL; 1.
DR SMART; SM00327; VWA; 2.
DR SUPFAM; SSF69848; LCCL domain; 1.
DR SUPFAM; SSF53300; vWA-like; 2.
DR PROSITE; PS50820; LCCL; 1.
DR PROSITE; PS50234; VWFA; 2.
PE 4: Predicted;
FT DOMAIN 2..95
FT /note="LCCL"
FT /evidence="ECO:0000259|PROSITE:PS50820"
FT DOMAIN 139..324
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 341..511
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 102..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EFB13216.1"
FT NON_TER 524
FT /evidence="ECO:0000313|EMBL:EFB13216.1"
SQ SEQUENCE 524 AA; 56871 MW; A9860956288CE864 CRC64;
SVPIAITCFT RGLDIRKEKA DVLCPGGCAL EEFSVFGNIV YASVSSICGA AVHRGVISNS
GGPVRIYSLP GRENYSSVAA NGIQSQTLSR WSASFTVTKG KSGTQEATGQ AVSTAHPSTG
KRLKKTSEKK TGNKDCKADI AFLIDGSFNI GQRRFNLQKN FVGKVALMLG IGTEGPHVGL
VQASEHPKIE FYLKNFTSAK DVLFAIKEVG FRGGNSNTGK ALKHTAQKFF TADTGVRKGI
PKVVVVFIDG WPSDDIEEAG IVAREFGVNV FIVSVAKPIP EELGMVQDVA FVDKAVCRNN
GFFSYHMPNW FGTTKYVKPL VQKLCTHEQM MCSKTCYNSV NIAFLIDGSS SVGDSNFRLM
LEFVSNIAKT FEISDIGAKI AAVQFTYDQR TEFSFTDYST KENVLAVIRN IRYMSGGTAT
GDAISFTVRN VFGPVRDSPN KNFLVIVTDG QSYDDVRGPA AAAHDAGITI FSVGVAWAPL
DDLKDMASKP KESHAFFTRE FTGLEPIVSD VIRGICRDFL ESQQ
//
