ID D2HAY2_AILME Unreviewed; 377 AA.
AC D2HAY2;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=RING-type domain-containing protein {ECO:0000259|PROSITE:PS50089};
DE Flags: Fragment;
GN ORFNames=PANDA_007637 {ECO:0000313|EMBL:EFB27119.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB27119.1};
RN [1] {ECO:0000313|EMBL:EFB27119.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
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DR EMBL; GL192642; EFB27119.1; -; Genomic_DNA.
DR RefSeq; XP_011223002.1; XM_011224700.2.
DR AlphaFoldDB; D2HAY2; -.
DR STRING; 9646.ENSAMEP00000020748; -.
DR GeneID; 105237517; -.
DR KEGG; aml:105237517; -.
DR CTD; 168433; -.
DR eggNOG; KOG4628; Eukaryota.
DR HOGENOM; CLU_049885_1_2_1; -.
DR InParanoid; D2HAY2; -.
DR OMA; CFELYKP; -.
DR OrthoDB; 5474929at2759; -.
DR TreeFam; TF317486; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd02122; PA_GRAIL_like; 1.
DR CDD; cd16802; RING-H2_RNF128-like; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46539; E3 UBIQUITIN-PROTEIN LIGASE ATL42; 1.
DR PANTHER; PTHR46539:SF30; RING FINGER PROTEIN 149; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 35..377
FT /note="RING-type domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015088270"
FT TRANSMEM 190..211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 256..297
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 326..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 358..377
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 377
FT /evidence="ECO:0000313|EMBL:EFB27119.1"
SQ SEQUENCE 377 AA; 42255 MW; EDFFFDF4258B6532 CRC64;
MNLRRIGTHG NNTASSWLMK FSFLWLLGQN CCSASAVWTA YMNISFHVGN RMLSELGETG
VFGRSSTLKR VAGVIVPPEG KTQNACNPNT SFRRSKNSEN WLALVERGGC SFSQKIKVAV
EKGASGVIIY NFPGTGNQVF PMFHQAFEDI VVVMIGNLKG MEILHLIQKG VHVTVIVEVG
RKHIIWMNHY FVSFVIVTTA TLAYFIFYHI WKLWVTRIQN RRWQRLTTDL KKAFGQLQLR
VLKEGDEEIS PNGDSCVVCF ELYKPNDTVR ILTCKHFFHK NCIDPWILAH GTCPMCKCDV
LKALGIQVDV EDGTESLQVL MSNELSGNLP SEEGTNNELP PARGLDEVSP VVEGEEPPPP
QNDRRPPEVA EDVHPSP
//
