ID D2HBX6_AILME Unreviewed; 911 AA.
AC D2HBX6;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Calcium-activated chloride channel regulator 1 {ECO:0000256|ARBA:ARBA00041120};
DE Flags: Fragment;
GN ORFNames=PANDA_008060 {ECO:0000313|EMBL:EFB27808.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB27808.1};
RN [1] {ECO:0000313|EMBL:EFB27808.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC {ECO:0000256|ARBA:ARBA00004239}.
CC -!- SIMILARITY: Belongs to the CLCR family.
CC {ECO:0000256|ARBA:ARBA00006398}.
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DR EMBL; GL192671; EFB27808.1; -; Genomic_DNA.
DR AlphaFoldDB; D2HBX6; -.
DR MEROPS; M87.001; -.
DR HOGENOM; CLU_005812_0_1_1; -.
DR InParanoid; D2HBX6; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005229; F:intracellular calcium activated chloride channel activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00198; vWFA; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR004727; CLCA_chordata.
DR InterPro; IPR013642; CLCA_N.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR NCBIfam; NF041940; choice_anch_X; 1.
DR NCBIfam; TIGR00868; hCaCC; 1.
DR PANTHER; PTHR10579; CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR; 1.
DR PANTHER; PTHR10579:SF52; CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR 1; 1.
DR Pfam; PF08434; CLCA; 1.
DR Pfam; PF13519; VWA_2; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00023049};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00023049};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..911
FT /note="Calcium-activated chloride channel regulator 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003032009"
FT DOMAIN 306..475
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT NON_TER 911
FT /evidence="ECO:0000313|EMBL:EFB27808.1"
SQ SEQUENCE 911 AA; 99628 MW; 64FDF9FBDAC25BD4 CRC64;
MGSFKSSVFI LVLHLLEGAL SNSLIQLNNN GYEGIVIAID PNVPEDETLI QHIKDMVTQA
SPYLFEATEK RFYFKNVAIL IPENWKTKPE YVRPKLETYN NADVLIAEPN PAGNDEPYTE
QMGNCGEKGE RIHFTPNFLT GKVASQYGSQ ERVFVHEWAH LRWGVYDEYN NNQKFYLFNK
KREAVRCSKG ITGKYEAIQC QGGSCTNKPC RIDTATGLYK EGCEFIPFEP QTEKASIMFS
QSIGSVVEFC TEKNHNKEAP NPQNQKCNLR STWEVIRDSE DFQKTTPMTT QPPAPTFSLL
QIGQRIVCLV LDKSGSMSNG DRLKRLNQAG KLFLLQIVEQ GSWVGMVTFD SAAHVQSELV
QINGATERDA LTKSLPTVAS GGTSICSGLR SAFAVIRKKF STDGSEIVLL TDGEDNTISS
CFNEVKQSGA VIHTVALGPS AAKELEELSK MTGGLQTYAS DQAQNNGLID AFGALSSGNG
AASQRAIQLE SKGLTLQNNQ WMNGTVLVDS TVGNDTLFLI TWTTQLPQIL LQDPSGKKHD
GFVVDTNAKM AYLQIPGTAK VGPWSYSLQA SSQTLTLTVT SRASSATLPP ITVTSKMNKD
AGKFPSPMAV YAKIHQGSLP ILRATVTAVI ESVNGKTVTL ELLDNGAGAD AAKDDGIYSR
YFTAYDTNGR YGVKVWALGG INAAGQRVTP QQNGAMYIPG WIENGEIKWN PPRPEISKND
LQGNQVCFSR TSSGGSFVAT GVPQAPIPDL FPPCQITDLK ANIHGYKFIN LTWTAPGDDY
DHGTAHKYII RISTSILDLR DKFNESLQVN TSNLIPKEAN SKEVFVFTPE NISFENGTDL
FIAIQAVDKS NLKSEISNIV GVSLFIPPQS PPETPTPSPP CPDINVNSTI PGLHILKIMW
KWLGELQLSV A
//
