ID D2HLA9_AILME Unreviewed; 217 AA.
AC D2HLA9;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=GRB2 related adaptor protein {ECO:0000313|Ensembl:ENSAMEP00000004797.1};
DE Flags: Fragment;
GN Name=GRAP {ECO:0000313|Ensembl:ENSAMEP00000004797.1};
GN ORFNames=PANDA_012258 {ECO:0000313|EMBL:EFB16031.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB16031.1};
RN [1] {ECO:0000313|EMBL:EFB16031.1, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000004797.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; GL193001; EFB16031.1; -; Genomic_DNA.
DR RefSeq; XP_002923174.1; XM_002923128.3.
DR STRING; 9646.ENSAMEP00000004797; -.
DR Ensembl; ENSAMET00000004990.2; ENSAMEP00000004797.1; ENSAMEG00000004558.2.
DR GeneID; 100474815; -.
DR KEGG; aml:100474815; -.
DR CTD; 10750; -.
DR eggNOG; KOG3601; Eukaryota.
DR GeneTree; ENSGT00940000156254; -.
DR HOGENOM; CLU_073617_1_0_1; -.
DR OMA; NKGDMLK; -.
DR OrthoDB; 25371at2759; -.
DR TreeFam; TF354288; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR CDD; cd09941; SH2_Grb2_like; 1.
DR CDD; cd11948; SH3_GRAP_N; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR035645; GRAP_N_SH3.
DR InterPro; IPR043539; Grb2-like.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46037:SF2; GRB2-RELATED ADAPTER PROTEIN; 1.
DR PANTHER; PTHR46037; PROTEIN ENHANCER OF SEVENLESS 2B; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF00018; SH3_1; 2.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50002; SH3; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..58
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 60..159
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 158..217
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT NON_TER 217
FT /evidence="ECO:0000313|EMBL:EFB16031.1"
SQ SEQUENCE 217 AA; 25351 MW; 28AD53F05817DF2C CRC64;
MESVALYSFQ ATESDELAFN KGDTLKILNM EDDQNWYKAE LRGAEGFIPK NYIRVKPHPW
YSGRISRQLA EEILMKRNHL GAFLIRESES SPGEFSVSVN YGDQVQHFKV LREASGKYFL
WEEKFNSLNE LVDFYRTTTI AKQRQVFLRD EEPLLKSPQA CFAQAQFDFS AQDSSQLSFH
RGDIIEVLEH LDPHWWRGRL CGRVGFFPRS YVQPVQL
//
