ID D2HLN8_AILME Unreviewed; 491 AA.
AC D2HLN8;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Keratin, type II cytoskeletal 8 {ECO:0000256|ARBA:ARBA00039429};
DE AltName: Full=Cytokeratin-8 {ECO:0000256|ARBA:ARBA00042964};
DE AltName: Full=Keratin-8 {ECO:0000256|ARBA:ARBA00042886};
DE AltName: Full=Type-II keratin Kb8 {ECO:0000256|ARBA:ARBA00043133};
DE Flags: Fragment;
GN ORFNames=PANDA_012426 {ECO:0000313|EMBL:EFB17400.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB17400.1};
RN [1] {ECO:0000313|EMBL:EFB17400.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
CC -!- FUNCTION: Together with KRT19, helps to link the contractile apparatus
CC to dystrophin at the costameres of striated muscle.
CC {ECO:0000256|ARBA:ARBA00037766}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus matrix {ECO:0000256|ARBA:ARBA00004109}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR EMBL; GL193014; EFB17400.1; -; Genomic_DNA.
DR RefSeq; XP_002923293.1; XM_002923247.3.
DR AlphaFoldDB; D2HLN8; -.
DR GeneID; 100465851; -.
DR KEGG; aml:100465851; -.
DR CTD; 3856; -.
DR HOGENOM; CLU_012560_5_4_1; -.
DR InParanoid; D2HLN8; -.
DR OrthoDB; 4640531at2759; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR GO; GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45616:SF26; KERATIN, TYPE II CYTOSKELETAL 8; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 3.
DR SUPFAM; SSF46579; Prefoldin; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 99..410
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 103..242
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 308..388
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 491
FT /evidence="ECO:0000313|EMBL:EFB17400.1"
SQ SEQUENCE 491 AA; 54436 MW; 4D67BD7952F6E0A5 CRC64;
MSIRVTQKSY KMSSSGPRAF SSRSYTSGPG SRISSSTFSR VGGSGSSFRG GLSSSMSVVG
GYGGAGAPGG ITAVSVNQSL LSPLKLEVDP NIQAVRTQEK EQIKTLNNKF ANFIDKVRHL
EQQNKILETK WGLLQQQKTA RSNIDNMFES YINNLRRQLD TLGQEKLKLE VELGNMQGLV
EDFKNKYEEE IKERADMENE FVLIKKDVDE AYMNKVELES RLEGLTDEIN FLRQLYEEEI
RELQSQISDT SVVLSMDNSH CLDLDGIIAE VKAQYEDIAN RSRAEAEAMY QIKYEELQTL
AGKHGDDLRR TKTEISEMNR SISRLQAEIE ALKNQRAALE AAIADAEQRG ELAIKDANAK
VAELEAALQR AKQDMARQLR EYQELMNVKL ALDIEIATYR KLLEGEESRL ESGMQNMSIH
TKTTSGYSGG LSSAYGGLTS PGLNYGLSSF QSSFGPAGSF SRSSSSKAVV VKKIETRDGK
LVSESSDVLS K
//
