ID D2HR27_AILME Unreviewed; 295 AA.
AC D2HR27;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Keratin 222 {ECO:0000313|Ensembl:ENSAMEP00000008586.1};
DE Flags: Fragment;
GN Name=KRT222 {ECO:0000313|Ensembl:ENSAMEP00000008586.1};
GN ORFNames=PANDA_014412 {ECO:0000313|EMBL:EFB20200.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB20200.1};
RN [1] {ECO:0000313|EMBL:EFB20200.1, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000008586.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR EMBL; GL193207; EFB20200.1; -; Genomic_DNA.
DR RefSeq; XP_002924985.1; XM_002924939.3.
DR STRING; 9646.ENSAMEP00000008586; -.
DR Ensembl; ENSAMET00000008949.2; ENSAMEP00000008586.1; ENSAMEG00000008167.2.
DR GeneID; 100464930; -.
DR KEGG; aml:100464930; -.
DR CTD; 125113; -.
DR eggNOG; ENOG502QQ07; Eukaryota.
DR GeneTree; ENSGT00940000159655; -.
DR HOGENOM; CLU_101833_0_0_1; -.
DR OMA; EEGCLHT; -.
DR OrthoDB; 4111230at2759; -.
DR TreeFam; TF332442; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR47082; KERATIN-LIKE PROTEIN KRT222; 1.
DR PANTHER; PTHR47082:SF1; KERATIN-LIKE PROTEIN KRT222; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT DOMAIN 1..150
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT COILED 34..149
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 295
FT /evidence="ECO:0000313|EMBL:EFB20200.1"
SQ SEQUENCE 295 AA; 34299 MW; AA8098B05814783E CRC64;
MELSQLLNEI RANYEKLLTR NQIETVLSTR IQLEEDMSKK MDKDEEALKA AQAELKEARR
QWHHLQVEIE SLQAVERGLE NSLHASEQHY QMQLQDLEAV IEGLEKELQE VRRGIEKQLQ
EHEMLLNTKM RLEQEIATYR RLLEKEEIRY YGCIQGEKKE QKPTTSRVGF VLPSAIINEI
SFSTKLPQKY ENEKVETVTK QAILNGNIVK ESTEARGTIQ TERVDEVIKE WEGSFFKDNP
RLRKKSVSLR FDLHLAATDE GCLQTKQDNL PDIEVRLIMR RSCSIPSIKP PSAAN
//
