ID D2HRY3_AILME Unreviewed; 2122 AA.
AC D2HRY3;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 13-SEP-2023, entry version 62.
DE RecName: Full=Bromodomain adjacent to zinc finger domain 2B {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=PANDA_014792 {ECO:0000313|EMBL:EFB13044.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB13044.1};
RN [1] {ECO:0000313|EMBL:EFB13044.1}
RP NUCLEOTIDE SEQUENCE.
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Li J., Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 0:0-0(2009).
CC -!- SIMILARITY: Belongs to the WAL family. {ECO:0000256|ARBA:ARBA00007444}.
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DR EMBL; GL193254; EFB13044.1; -; Genomic_DNA.
DR HOGENOM; CLU_000899_0_0_1; -.
DR InParanoid; D2HRY3; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd05503; Bromo_BAZ2A_B_like; 1.
DR CDD; cd01397; HAT_MBD; 1.
DR CDD; cd15630; PHD_BAZ2B; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR037374; BAZ2A/B_Bromo.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR018501; DDT_dom.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR028941; WHIM2_dom.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45915:SF1; BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2B; 1.
DR PANTHER; PTHR45915; TRANSCRIPTION INTERMEDIARY FACTOR; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF02791; DDT; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF00628; PHD; 1.
DR Pfam; PF15613; WSD; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00571; DDT; 1.
DR SMART; SM00391; MBD; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS50827; DDT; 1.
DR PROSITE; PS50982; MBD; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 3: Inferred from homology;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 691..762
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT DOMAIN 1039..1104
FT /note="DDT"
FT /evidence="ECO:0000259|PROSITE:PS50827"
FT DOMAIN 1885..1935
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 2031..2101
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 92..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 364..385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 411..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 477..650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 665..693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 791..828
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 973..995
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1217..1293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1431..1494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1533..1559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1627..1646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1952..2012
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..194
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..214
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..239
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..276
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 281..301
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..507
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 518..547
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 556..612
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 622..644
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 665..685
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 791..822
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1251..1272
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1437..1494
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1627..1645
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1982..1997
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EFB13044.1"
FT NON_TER 2122
FT /evidence="ECO:0000313|EMBL:EFB13044.1"
SQ SEQUENCE 2122 AA; 235981 MW; EAC82818A3332CB8 CRC64;
GHLFRAAGDQ PFNLSTVSSA FPMVSHPVFG LHSASSGHSE FGGLGTLGTP TALAAHPQLA
SFPGAEWWRT TDVHSRTGAT FFPPLLGIPP LFAPPAQNHD SSSFHSRTSG KSNRNGPEKG
VNGSINGNST SSVSGINTPV LSSTASSSVG QTKSVSSGGG NRKCNQEQSK NQPLDARADK
IKDKKPRKKA MESSSNSDSD SGTSSDTSSE GISSSDSDDL EEDEEEDQSI EESEDDDSDS
ESEAQHKSNN QVLLHGISDP KADGQKAAEK AQEKRIHQPL PLVSESQTHS SFQSQQKQPQ
VLSQQLPFIF QSSQAKEESV NKHTSVIQST GLVSNVKPLS LVNQAKKETY MKLIVPSPDV
LKAGNKNTSE ESSPLTSEMR SKREQYKQTF PAQLKKQESS KSLKKVIAAL SNPKATSSSP
AHPKQTVENN HPNPFLTNAL LGNHQPNGVI QSVIQEAPLA LTTKTKMQSK INENIATASS
TPFSSPVNLS TSGRRTSSNQ TAVIPSASPV VHPQGKEKAV SNNASMVKTQ HHPHPATSLV
EQFRGTDSDI PSSKDSEESN EDEEEDDEEE DEEDDEDDES DDSQSESDSN SESDTEGSEE
DDDDDKDQDE SDSDTEGEKT SMKLNKTTSS VKSPSISLTA HSTPRNLHIA KAPGSAPAAL
CSESQSPAFL GTPSSTLTSS PHSGTSKRRR VTDERELRVP LEYGWQRETR IRNFGGRLQG
EVAYYAPCGK KLRQYPEVIK YLSRNGIMDI SRDNFSFSAK IRVGDFYEAR DGPQGMQWCL
LKEEDVIPRI RAMEGRRGRP PNPDRQQARE ESRMRRRKGR PPNVGSAEFL DNTDAKLLRK
LQAQEIARQA AQIKLLRKLQ KQEQARVAKE AKKQQAIMAA EEKRKQKEQI KIMKQQEKIK
RIQQIRMEKE LRAQQILEAK KKKKEEAANA KLLEAEKRIK EKEMRRQQAV LLKHQERERR
RQHMMLMKAM EARKKAEEKE RLKQEKRDEK RLNKERKLEQ RRLELEMAKE LKKPNEDMCL
ADQKPLPELP RIPGLVLSGS TFSDCLMVVQ FLRNFGKVLG FDVNIDVPNL SVLQEGLLNI
GDSMGEVQDL LVRLLSAAVC DPGLITGYKA KTALGEHLLN VGVNRDNVSE ILQIFMEAHC
GQTELTESLK TKAFQAHTPA QKASVLAFLI NELACSKSVV SEIDKNIDYM SNLRRDKWVV
EGKLRKLRII HAKKTGKRDT SGGIDLGEEQ HPLGTPTPGR KRRRKGGDSD FDDDDDDDSD
DQADEDDEDE EDKEDKKGKK TDICEDEDEG DQAASVEELE KQIEKLSKQQ SQYRRKLFDA
SHSLRSMMFG QDRYRRRYWI LPQCGGIFVE GMESGEGLEE IAKEREKLKK AESIQIKEEI
FETSEDTLNC SNPDLCEQKE DAKDKDNTNL FLQKPGSFSK LSKLLEVAKM PPESDVMTPK
PNSSTNGCAL SYQNSGKHSL GSIQSTATQS NMEKTDSNNL FSTGSSGPGK FYSPLPNDQL
LKTLTEKNRQ WFSLLPRTPC DDTSLTHADV AAASVGTSQS QPPSTSPSPA PAPLLGSSSA
QNPVGLNPFA VSPLQMKSGV SMMGLQFCGW PTGVLTSNIP FTSPLPSLGS GLGLSEGNGN
SFLNPNVASS KSESPVPQNE KVSATQPAPV EVAKPVDFPN PKPIPEEMQF GWWRIIDPED
LKALLKVLHL RGIREKALQK QIQKHLDYIT QACIKNKDVA IIELNENEEN QVTRDIVENW
SVEDQAMEMD LSILQQVEDL ERRVASASLQ VKGWMCPEPA SEREDLVYFE HKSFSKLCKE
HDGEFTGEEE SSAHALERKS DNPLDIAVTR LADLERNIER RIEEDIAPGL RVWRRALSEA
RSAAQVALCI QQLQKSIAWE KSIMKVYCQI CRKGDNEELL LLCDGCDKGC HTYCHRPKIT
TIPDGDWFCP ACIAKASGQT LKVKKLHIKG KKTNESKKGK KVTLTGDTED EDSASTNSSL
KRGNKDLKKR KMEENTSVNL SKQESFTSVK KPKRDDSKDL ALCSMILTEM ETHEDAWPFL
LPVNLKLVPG YKKVIKKPMD FSTIREKLSS GQYPNLETFA VDVRLVFDNC ETFNEDDSDI
GRAGHNMRKY FEKKWTDIFK VS
//
