ID D2HVL1_AILME Unreviewed; 257 AA.
AC D2HVL1;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 24-JAN-2024, entry version 58.
DE RecName: Full=Sesquipedalian {ECO:0000256|RuleBase:RU369082};
DE Short=Ses {ECO:0000256|RuleBase:RU369082};
DE AltName: Full=PH domain-containing endocytic trafficking adaptor {ECO:0000256|RuleBase:RU369082};
DE Flags: Fragment;
GN ORFNames=PANDA_016417 {ECO:0000313|EMBL:EFB20333.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB20333.1};
RN [1] {ECO:0000313|EMBL:EFB20333.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
CC -!- FUNCTION: Plays a role in endocytic trafficking. Required for receptor
CC recycling from endosomes, both to the trans-Golgi network and the
CC plasma membrane. {ECO:0000256|RuleBase:RU369082}.
CC -!- SUBUNIT: Forms homodimers and heterodimers with PHETA. Interacts with
CC OCRL and INPP5B. {ECO:0000256|RuleBase:RU369082}.
CC -!- SUBCELLULAR LOCATION: Early endosome {ECO:0000256|RuleBase:RU369082}.
CC Recycling endosome {ECO:0000256|RuleBase:RU369082}. Golgi apparatus,
CC trans-Golgi network {ECO:0000256|RuleBase:RU369082}. Cytoplasmic
CC vesicle, clathrin-coated vesicle {ECO:0000256|RuleBase:RU369082}.
CC -!- SIMILARITY: Belongs to the sesquipedalian family.
CC {ECO:0000256|RuleBase:RU369082}.
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DR EMBL; GL193478; EFB20333.1; -; Genomic_DNA.
DR AlphaFoldDB; D2HVL1; -.
DR eggNOG; ENOG502QQ94; Eukaryota.
DR HOGENOM; CLU_060423_0_1_1; -.
DR InParanoid; D2HVL1; -.
DR OMA; WELQGPT; -.
DR TreeFam; TF326731; -.
DR GO; GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0055037; C:recycling endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005802; C:trans-Golgi network; IEA:UniProtKB-UniRule.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0007032; P:endosome organization; IEA:UniProtKB-UniRule.
DR GO; GO:0001881; P:receptor recycling; IEA:UniProtKB-UniRule.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:UniProtKB-UniRule.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR045188; Boi1/Boi2-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR22902; SESQUIPEDALIAN; 1.
DR PANTHER; PTHR22902:SF15; SESQUIPEDALIAN-2; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|RuleBase:RU369082};
KW Endosome {ECO:0000256|RuleBase:RU369082};
KW Golgi apparatus {ECO:0000256|RuleBase:RU369082};
KW Phosphoprotein {ECO:0000256|RuleBase:RU369082}.
FT DOMAIN 17..121
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 153..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 257
FT /evidence="ECO:0000313|EMBL:EFB20333.1"
SQ SEQUENCE 257 AA; 28838 MW; 7CBC96C59A8E069F CRC64;
MKLNERSVAH YALSDSPADH TGFLRTWGGP GTPPTPSGTG RRCWFVLKGN LLFSFESRES
RAPLSLVVLE GCTVELAEAP MSEEFAFAIR FDAPGVRPHL LAADGPAAQE AWVKALSRAS
FGYMRLVVRE LESQLRNARH SLALHRHSSW KATGSHWKPQ APDRRSSGLE NGHSLFKDCS
PMDLVEERGS RPARRGLAEW QGPASLFVGR RQSPSFPETS YFSTLHNLYG QEIMELRQRW
LQRVWGSQTE RKNQDGP
//
