ID D2ILA8_9SAUR Unreviewed; 164 AA.
AC D2ILA8;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=Neurotrophin-3 {ECO:0000256|ARBA:ARBA00018014, ECO:0000256|RuleBase:RU365037};
DE Short=NT-3 {ECO:0000256|RuleBase:RU365037};
DE Flags: Fragment;
GN Name=NT3 {ECO:0000313|EMBL:ADA71521.1};
OS Leptodeira annulata annulata.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Dipsadidae; Leptodeira.
OX NCBI_TaxID=427723 {ECO:0000313|EMBL:ADA71521.1};
RN [1] {ECO:0000313|EMBL:ADA71521.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19643196; DOI=10.1016/j.ympev.2009.07.022;
RA Daza J.M., Smith E.N., Paez V.P., Parkinson C.L.;
RT "Complex evolution in the Neotropics: the origin and diversification of the
RT widespread genus Leptodeira (Serpentes: Colubridae).";
RL Mol. Phylogenet. Evol. 53:653-667(2009).
CC -!- FUNCTION: Seems to promote the survival of visceral and proprioceptive
CC sensory neurons. {ECO:0000256|ARBA:ARBA00003312,
CC ECO:0000256|RuleBase:RU365037}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU365037}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU365037}.
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DR EMBL; GQ334670; ADA71521.1; -; Genomic_DNA.
DR AlphaFoldDB; D2ILA8; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005165; F:neurotrophin receptor binding; IEA:InterPro.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR015578; Neurotrophin-3.
DR InterPro; IPR045815; NTF3_N.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR PANTHER; PTHR11589:SF4; NEUROTROPHIN-3; 1.
DR Pfam; PF00243; NGF; 1.
DR Pfam; PF19338; NTF3_N; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01914; NEUROTROPHN3.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|RuleBase:RU365037};
KW Growth factor {ECO:0000256|RuleBase:RU365037};
KW Secreted {ECO:0000256|RuleBase:RU365037};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 118..164
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT REGION 24..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..41
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADA71521.1"
FT NON_TER 164
FT /evidence="ECO:0000313|EMBL:ADA71521.1"
SQ SEQUENCE 164 AA; 18636 MW; 1106164D3C1FDF24 CRC64;
QGSVSEDSMN SFLKTLIQAG IWKNKTPKQT DRTKDGVPTT VRKTEVEPQS ATSQDIRLGF
QPVVSLDAEL LRQQRRFSSP RVLLSENTPL EPPPLYLMEE PMVVNRTSRR KRYSEGKTHR
GEYSVCDSES RWVTDKTSAV DIRGHQVTVL GEIRMGPSPV KQYF
//
