ID D2JTZ8_RHIET Unreviewed; 375 AA.
AC D2JTZ8;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Serine hydroxymethyltransferase {ECO:0000313|EMBL:ACZ99417.1};
DE Flags: Fragment;
GN Name=glyA {ECO:0000313|EMBL:ACZ99417.1};
OS Rhizobium etli bv. phaseoli.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX NCBI_TaxID=147700 {ECO:0000313|EMBL:ACZ99417.1};
RN [1] {ECO:0000313|EMBL:ACZ99417.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=16NJ-2 {ECO:0000313|EMBL:ACZ99417.1};
RX PubMed=20675442; DOI=10.1128/AEM.01001-10;
RA Lozano L., Hernandez-Gonzalez I., Bustos P., Santamaria R.I., Souza V.,
RA Young J.P., Davila G., Gonzalez V.;
RT "Evolutionary dynamics of insertion sequences in relation to the
RT evolutionary histories of the chromosome and symbiotic plasmid genes of
RT Rhizobium etli populations.";
RL Appl. Environ. Microbiol. 76:6504-6513(2010).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|PIRSR:PIRSR000412-50};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the SHMT family.
CC {ECO:0000256|ARBA:ARBA00006376}.
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DR EMBL; GU084605; ACZ99417.1; -; Genomic_DNA.
DR AlphaFoldDB; D2JTZ8; -.
DR GO; GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:InterPro.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0019264; P:glycine biosynthetic process from serine; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:InterPro.
DR CDD; cd00378; SHMT; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR HAMAP; MF_00051; SHMT; 1.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR InterPro; IPR001085; Ser_HO-MeTrfase.
DR InterPro; IPR019798; Ser_HO-MeTrfase_PLP_BS.
DR InterPro; IPR039429; SHMT-like_dom.
DR PANTHER; PTHR11680; SERINE HYDROXYMETHYLTRANSFERASE; 1.
DR PANTHER; PTHR11680:SF28; SERINE HYDROXYMETHYLTRANSFERASE; 1.
DR Pfam; PF00464; SHMT; 1.
DR PIRSF; PIRSF000412; SHMT; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00096; SHMT; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Methyltransferase {ECO:0000313|EMBL:ACZ99417.1};
KW One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR000412-50};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ACZ99417.1}.
FT DOMAIN 1..360
FT /note="Serine hydroxymethyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF00464"
FT MOD_RES 205
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR000412-50"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACZ99417.1"
FT NON_TER 375
FT /evidence="ECO:0000313|EMBL:ACZ99417.1"
SQ SEQUENCE 375 AA; 40415 MW; 02325DEAF048AC78 CRC64;
QRHEIELIAS ENIVSRAVLE AQGSIMTNKY AEGYPGKRYY GGCQFVDIAE ELAIERAKKL
FGVNFANVQP NSGSQMNQAV FLALLQPGDT FMGLDLNSGG HLTHGSPVNM SGKWFNVISY
GVREGDNLLD MDDVARKAEQ HRPKLIIAGG TAYSRIWDWK RFREIADSVG AYLMVDMAHI
AGLVAGGQHP SPFPHCHVAT TTTHKSLRGP RGGVILTNEE DLAKKFNSAV FPGLQGGPLM
HIIAAKAVAF GEALQPEFKE YAAQVVKNAR ALAETLISGG LDVVSGGTDN HLMLVDLRKK
NATGKRAEAA LGRAYVTCNK NGIPFDPEKP FVTSGVRLGA PAGTTRGFKE AEFREIGNLI
VEVLDGLKVA NSDEG
//
