ID D2KVI9_STREQ Unreviewed; 155 AA.
AC D2KVI9;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Ferric uptake regulation protein {ECO:0000313|EMBL:BAI63407.1};
GN Name=perR {ECO:0000313|EMBL:BAI63407.1};
OS Streptococcus dysgalactiae subsp. equisimilis (Streptococcus equisimilis).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=119602 {ECO:0000313|EMBL:BAI63407.1};
RN [1] {ECO:0000313|EMBL:BAI63407.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=164 {ECO:0000313|EMBL:BAI63407.1};
RX PubMed=22900646; DOI=10.1186/1471-2164-13-404;
RA Okumura K., Shimomura Y., Yamagata Murayama S., Yagi J., Ubukata K.,
RA Kirikae T., Miyoshi-Akiyama T.;
RT "Evolutionary paths of streptococcal and staphylococcal superantigens.";
RL BMC Genomics 13:404-404(2012).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|PIRSR:PIRSR602481-1};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR602481-1};
CC -!- SIMILARITY: Belongs to the Fur family. {ECO:0000256|ARBA:ARBA00007957}.
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DR EMBL; AB479810; BAI63407.1; -; Genomic_DNA.
DR RefSeq; WP_003059915.1; NZ_MATZ01000022.1.
DR AlphaFoldDB; D2KVI9; -.
DR PATRIC; fig|119602.33.peg.19; -.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd07153; Fur_like; 1.
DR Gene3D; 3.30.1490.190; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR002481; FUR.
DR InterPro; IPR043135; Fur_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR33202:SF8; PEROXIDE-RESPONSIVE REPRESSOR PERR; 1.
DR PANTHER; PTHR33202; ZINC UPTAKE REGULATION PROTEIN; 1.
DR Pfam; PF01475; FUR; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR602481-1};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRSR:PIRSR602481-1}.
FT BINDING 104
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR602481-1"
FT BINDING 107
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR602481-1"
FT BINDING 144
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR602481-1"
FT BINDING 147
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR602481-1"
SQ SEQUENCE 155 AA; 17735 MW; 05375A8E0762F8F4 CRC64;
MDIHSHQQAL DAYENVLEHL RDKHIRITET RKAIISYMIQ STEHPSADKI YRDLQPKFPN
MSLATVYNNL KVLVDEGFVA ELKISNDLTT YYDFMGHQHV NVVCEVCGKI ADFMDVDVMD
IAKEAHQQTG YKVTRIPVIA YGVCPECQVK GKSDF
//
