ID   D2SMM4_PAPAN            Unreviewed;       528 AA.
AC   D2SMM4;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   RecName: Full=UDP-glucuronosyltransferase {ECO:0000256|RuleBase:RU362059};
DE            EC=2.4.1.17 {ECO:0000256|RuleBase:RU362059};
GN   Name=UGT2B46 {ECO:0000313|EMBL:ACJ63226.1};
OS   Papio anubis (Olive baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9555 {ECO:0000313|EMBL:ACJ63226.1};
RN   [1] {ECO:0000313|EMBL:ACJ63226.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Liver {ECO:0000313|EMBL:ACJ63226.1};
RA   Abildskov K.M., Weldy P.L., Garland M.;
RL   Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ACJ63226.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Liver {ECO:0000313|EMBL:ACJ63226.1};
RX   PubMed=20071451; DOI=10.1124/dmd.109.030635;
RA   Abildskov K., Weldy P., Garland M.;
RT   "Molecular cloning of the baboon UDP-glucuronosyltransferase 2B gene family
RT   and their activity in conjugating morphine.";
RL   Drug Metab. Dispos. 0:0-0(2010).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor
CC         beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223,
CC         ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;
CC         Evidence={ECO:0000256|ARBA:ARBA00000301,
CC         ECO:0000256|RuleBase:RU362059};
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004389}. Membrane
CC       {ECO:0000256|RuleBase:RU362059}; Single-pass membrane protein
CC       {ECO:0000256|RuleBase:RU362059}. Microsome membrane
CC       {ECO:0000256|ARBA:ARBA00004111}; Single-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004111}.
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00009995, ECO:0000256|RuleBase:RU003718}.
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DR   EMBL; EU856386; ACJ63226.1; -; mRNA.
DR   RefSeq; NP_001165616.1; NM_001172145.1.
DR   AlphaFoldDB; D2SMM4; -.
DR   CAZy; GT1; Glycosyltransferase Family 1.
DR   GeneID; 100337525; -.
DR   CTD; 100337525; -.
DR   BRENDA; 2.4.1.17; 4519.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015020; F:glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR   CDD; cd03784; GT1_Gtf-like; 1.
DR   Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   InterPro; IPR035595; UDP_glycos_trans_CS.
DR   PANTHER; PTHR48043; EG:EG0003.4 PROTEIN-RELATED; 1.
DR   PANTHER; PTHR48043:SF87; UDP-GLUCURONOSYLTRANSFERASE 2B7; 1.
DR   Pfam; PF00201; UDPGT; 1.
DR   SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR   PROSITE; PS00375; UDPGT; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW   ECO:0000256|RuleBase:RU003718};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362059};
KW   Microsome {ECO:0000256|ARBA:ARBA00022848};
KW   Signal {ECO:0000256|RuleBase:RU362059};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003718};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362059};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362059}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|RuleBase:RU362059"
FT   CHAIN           25..528
FT                   /note="UDP-glucuronosyltransferase"
FT                   /evidence="ECO:0000256|RuleBase:RU362059"
FT                   /id="PRO_5005126205"
FT   TRANSMEM        493..516
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362059"
SQ   SEQUENCE   528 AA;  60560 MW;  46FD1C004424893F CRC64;
     MSVKWTSVIL LIQLSFYFSS GSCGKVLVWA AEYSHWMNMK TILEELVQRG HEVTVLASSA
     SILFDPNNSS ALKIEVFPTS LAKTEFENII MQQIKRWSEL PKDTFWLYFS EIQDIMWKFG
     DITKKFCKDV VSNKKLMKKL QESRFDVVFA DAIFPCSELL AELLNTPLVY SLRFTPGYNF
     EKHCGGFLFP PSYVPVVLSE LSDQMTFMER VKNMIYMLYF DFCFQLYDMK KWDQFYSEVL
     GRPTTLSETM GKADIWLIRN SWNFQFPHPL LPNVDFVGGL HCKPAKPLPK EMEEFVQSSG
     ENGVVVFSLG SMVTNMKEER ANVIASALAQ IPQKVLWRFD GKKPDTLGLN TRLYKWIPQN
     DLLGHPKTRA FITHGGANGI YEAIYHGVPM VGIPLFADQP DNIAHMKTKG AAVRLDFDTM
     SSTDLANALK TVINDPLYKE NVMKLSRIQH DQPVKPLDRA VFWIEFVMQH KGAKHLRPAA
     HDLTWFQYHS LDVIGFLLAC VATVIFVIMK CLFCFWKFAR KGKKGKSD
//