ID D2T2J7_ACYPI Unreviewed; 512 AA.
AC D2T2J7; J9K1F6;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Chryptochrome 2-1 {ECO:0000313|EMBL:CAY26039.1};
GN Name=cry2-1 {ECO:0000313|EMBL:CAY26039.1};
OS Acyrthosiphon pisum (Pea aphid).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Hemiptera; Sternorrhyncha; Aphidomorpha;
OC Aphidoidea; Aphididae; Macrosiphini; Acyrthosiphon.
OX NCBI_TaxID=7029 {ECO:0000313|EMBL:CAY26039.1};
RN [1] {ECO:0000313|EMBL:CAY26039.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=YR2 {ECO:0000313|EMBL:CAY26039.1};
RA Cortes T., Ortiz-Rivas B., Miralles S., Gonzalez A., Martinez-Torres D.;
RT "Characterization of the circadian rhythm clockwork in the pea aphid
RT Acyrthosiphon pisum (Hemiptera: Aphididae).";
RL Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|PIRSR:PIRSR602081-1};
CC Note=Binds 1 FAD per subunit. {ECO:0000256|PIRSR:PIRSR602081-1};
CC -!- SIMILARITY: Belongs to the DNA photolyase class-1 family.
CC {ECO:0000256|ARBA:ARBA00005862}.
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DR EMBL; FN377570; CAY26039.1; -; mRNA.
DR RefSeq; NP_001164572.1; NM_001171101.1.
DR AlphaFoldDB; D2T2J7; -.
DR STRING; 7029.D2T2J7; -.
DR GeneID; 100165652; -.
DR CTD; 100165652; -.
DR eggNOG; KOG0133; Eukaryota.
DR HOGENOM; CLU_010348_3_4_1; -.
DR InParanoid; D2T2J7; -.
DR Gene3D; 1.25.40.80; -; 1.
DR Gene3D; 1.10.579.10; DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR036134; Crypto/Photolyase_FAD-like_sf.
DR InterPro; IPR036155; Crypto/Photolyase_N_sf.
DR InterPro; IPR005101; Cryptochr/Photolyase_FAD-bd.
DR InterPro; IPR002081; Cryptochrome/DNA_photolyase_1.
DR InterPro; IPR006050; DNA_photolyase_N.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR PANTHER; PTHR11455; CRYPTOCHROME; 1.
DR PANTHER; PTHR11455:SF30; CRYPTOCHROME-1; 1.
DR Pfam; PF00875; DNA_photolyase; 1.
DR Pfam; PF03441; FAD_binding_7; 1.
DR SUPFAM; SSF48173; Cryptochrome/photolyase FAD-binding domain; 1.
DR SUPFAM; SSF52425; Cryptochrome/photolyase, N-terminal domain; 1.
DR PROSITE; PS51645; PHR_CRY_ALPHA_BETA; 1.
PE 2: Evidence at transcript level;
KW Chromophore {ECO:0000256|ARBA:ARBA00022991};
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|PIRSR:PIRSR602081-1};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630, ECO:0000256|PIRSR:PIRSR602081-
KW 1}; Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 4..133
FT /note="Photolyase/cryptochrome alpha/beta"
FT /evidence="ECO:0000259|PROSITE:PS51645"
FT BINDING 290..297
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR602081-1"
FT BINDING 388..390
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR602081-1"
FT SITE 321
FT /note="Electron transfer via tryptophanyl radical"
FT /evidence="ECO:0000256|PIRSR:PIRSR602081-2"
FT SITE 375
FT /note="Electron transfer via tryptophanyl radical"
FT /evidence="ECO:0000256|PIRSR:PIRSR602081-2"
FT SITE 398
FT /note="Electron transfer via tryptophanyl radical"
FT /evidence="ECO:0000256|PIRSR:PIRSR602081-2"
SQ SEQUENCE 512 AA; 59148 MW; 1B08A3F449EA23FD CRC64;
MQNKHTVHWF RKGLRIHDNP SLREGLINAK TFRCIFILDP WFAGASNVGI NKWRFLLQCL
SDLDNSLKKL NSRLFVIKGQ PAEALPKLFR QWGTTNFTFE EDPEPFGRVR DQNIKVMCSE
LGISVITRCS HTLYQLDKII NVNGGKAPLT YHLFQNILEC IDPPERAVPS IDKEFLGNAF
TPTKYDHDKI FGVPTVEELG FEEINNIARH VWVGGETEAL IRLQCHLERK AFIASFGKPK
MTPQSLLASP TGLAPYLKFG CLSTRLYFSE LNELYKKIRK SQPPLSLHGQ LLWRDFFYCA
STNNPNFDRM VGNPICVQIP WDKNPRALSK WANGQTGYPW IDAIMIQLRQ EGWIHCIARH
AVACFLTWGD LWLSWEEGMK VFDELLLDAD WSVNAGYWMW YSCSSFYKEF IHCYCPVRFG
RKVDPNGDYI RRYIPALNNM PNKYIHEPWL APESIQITAN CIIGIDYPLP IVNHINASKI
NIERMKLAYQ QLSNCQPQLE NGKLILISSL RR
//
