ID D2V3R6_NAEGR Unreviewed; 869 AA.
AC D2V3R6;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC48682.1};
GN ORFNames=NAEGRDRAFT_63463 {ECO:0000313|EMBL:EFC48682.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC48682.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC48682.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
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DR EMBL; GG738850; EFC48682.1; -; Genomic_DNA.
DR RefSeq; XP_002681426.1; XM_002681380.1.
DR AlphaFoldDB; D2V3R6; -.
DR STRING; 5762.D2V3R6; -.
DR EnsemblProtists; EFC48682; EFC48682; NAEGRDRAFT_63463.
DR GeneID; 8852402; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_63463; -.
DR InParanoid; D2V3R6; -.
DR OrthoDB; 5476096at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 163..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 519..541
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 625..760
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 72..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..89
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 869 AA; 98064 MW; B51D572898D011F1 CRC64;
MFGNETVSSM EDMNGSSTNK PTVAQASSST DKKFSIIVTN EESKTSTDVN LMVDPPLYEI
ANENNHLHTT NIVNSRRPSN NSTTSSMIHP IHAKPHPIYG RRDTIFTFDE VITHLPEGTN
QTNQQQQLPS IEVNEKQNPT PGSNNSGNLL FGYCGRGVRI SHVLLILFII QGLVGLVPSL
ILMYTSGNSI LERVSKFQAQ QTQTYVNFEI SRIVNTSQLV IQHIRFELEN GFTLSNLTEM
TLFATYLRNL YVNRSPLTAV QFGMFMDNYV GTLDIPPIYP PVIEYLNGTG DLLYHYRLEE
DSIENPLQDR YLYNVEPFRF KPSHRPWYVP FTLPNATERR WSEIYVSTFG QLSINTAMPV
FVKENITAAV LSGKPIDQFN FQICDCNHPD HLYGVFGALF ALKGLNSFLN DTSRPYSFIS
YSFIMQRNGS VIASSRHNTT TSSSILEEEE EIDQVAAYII NLGLFKNSTI PGECTFKFRG
KNVAITPVYD NYGLSWAIVI GSKDADILKE LLSSGMTSVV VFIVILVAGS LALFVTVQLF
AQPLNNVHRK LSKILSDKNL SKDLSNPKIT TAGLIFFDIG EMENGINSLK RGVSAFSKFI
SPTIMKKVIR NEHYLDVGMI IQNMSILVLS ISNFSQLAEQ TDISTFVSLM TDYFGSLTKV
MEDHRGLIDM ITGERLQVVW NDSSMPVEEH EVRACKAAME AIEVVEELNN TWIKEKHLEM
DFSVCMSISS GNMMYGSIGS EHRLNFTAMG DDVNIAVKLA NLNPHYEADI LITENTYQHV
KNEFVCYFVD YIILNGKESP TMIYSLECER SVASDLQVKV ATDLELARNY WFQNNYRAMY
DICERLSLIS HSKIINNLLL KAKRKITHN
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