ID   D2V4C8_NAEGR            Unreviewed;       766 AA.
AC   D2V4C8;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   RecName: Full=adenylate cyclase {ECO:0000256|ARBA:ARBA00012201};
DE            EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201};
GN   ORFNames=NAEGRDRAFT_63679 {ECO:0000313|EMBL:EFC48361.1};
OS   Naegleria gruberi (Amoeba).
OC   Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC   Vahlkampfiidae; Naegleria.
OX   NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN   [1] {ECO:0000313|EMBL:EFC48361.1, ECO:0000313|Proteomes:UP000006671}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEG-M {ECO:0000313|EMBL:EFC48361.1,
RC   ECO:0000313|Proteomes:UP000006671};
RX   PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA   Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA   Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA   Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA   Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT   "The genome of Naegleria gruberi illuminates early eukaryotic
RT   versatility.";
RL   Cell 140:631-642(2010).
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC       {ECO:0000256|ARBA:ARBA00005381}.
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DR   EMBL; GG738851; EFC48361.1; -; Genomic_DNA.
DR   RefSeq; XP_002681105.1; XM_002681059.1.
DR   AlphaFoldDB; D2V4C8; -.
DR   EnsemblProtists; EFC48361; EFC48361; NAEGRDRAFT_63679.
DR   GeneID; 8849827; -.
DR   VEuPathDB; AmoebaDB:NAEGRDRAFT_63679; -.
DR   eggNOG; KOG1023; Eukaryota.
DR   InParanoid; D2V4C8; -.
DR   OrthoDB; 3076794at2759; -.
DR   Proteomes; UP000006671; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   PANTHER; PTHR43081:SF1; PH-SENSITIVE ADENYLATE CYCLASE RV1264; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        398..420
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          502..624
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   766 AA;  85736 MW;  E173EC26E73CA5E2 CRC64;
     MSRTTSRTSS KGNMVTPFSI DTIEEPESTP NSSDKKSRCW MCSPKKVLSL RNIIITLISS
     SIIIIAFIVW IIGFTASNSS TKILSDKLKD SSTERIVVMI EGMFTQAQEL ALSYRYFYDK
     QTNHMRNFLE DRSLYEYSVK NLLFSSLITR QGLINSVNFV FESGHVVGWE CNLNACDYFI
     SKQDDLRLMA YNYDFELETL ANSTTYEVPN FNASIIIPTY SIVTNAAKVD KSLRKTGMFF
     PISRHVLVSS MYVTSVAIPY YGLDGNMLGT SNVVFYVDTL NAKVRSANPS IGGYILVLED
     SGVIVAHSFA NLTANMEKPC YLGGNLLVQT LCSYLLPDQN SSSISDRFGN TPSSKFSLEG
     FSVQRKELKF PGITWHVLIA IPDEEILGDI LIQSYNTVWI SALVLVAAII FSVITTFSLF
     RTLSMLARCF TDIQNLDLDA PTIVKATSIL TAVYELRELQ NNFKSMIVTL KSIRKFVPVQ
     IIRKILITGR EASLGIEDAD ATIFFLDIAG FTTMSEKMEP KALVDLASSV FESCSQSINK
     HNGVIDKFIG DAVMALWNVP TRTKDHEYHA LQSAIEIQLE MEMKNVPVRI GIHSGRVKAG
     NIGSVDRFSF SVLGDCPNVA SRFEGANKVY MSKIICGSST IEVALLSEER LAIKDPSLKR
     IVNRRLDKLK LIGKEHPVLA YQIFLSENPK HTNGLDSRDL KMYEKGYDYL VEKQYKEALS
     IFYTLGDKAP NDMVIRRKIN LCRSLVENAG IVDGKKFEGF VEITGK
//