ID D2V7H7_NAEGR Unreviewed; 987 AA.
AC D2V7H7;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=RhoGEF domain-containing protein {ECO:0000313|EMBL:EFC47381.1};
GN ORFNames=NAEGRDRAFT_78898 {ECO:0000313|EMBL:EFC47381.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC47381.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC47381.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
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DR EMBL; GG738855; EFC47381.1; -; Genomic_DNA.
DR RefSeq; XP_002680125.1; XM_002680079.1.
DR AlphaFoldDB; D2V7H7; -.
DR EnsemblProtists; EFC47381; EFC47381; NAEGRDRAFT_78898.
DR GeneID; 8849424; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_78898; -.
DR eggNOG; KOG3522; Eukaryota.
DR InParanoid; D2V7H7; -.
DR OrthoDB; 6929at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF159; RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR JJ; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000006671}.
FT DOMAIN 356..554
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 216..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 770..826
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 839..859
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 872..969
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..113
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..128
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..280
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..304
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 777..822
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 840..859
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 878..921
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 934..948
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 953..969
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 987 AA; 109354 MW; 4B92194D21DCFEDF CRC64;
MSSTKQLPVP PPKPPRSSFI TTTTTTPLVN NNSETITTNT VTDSPTIATT NNSRTTTTTS
SSRSYTLRPN ASPPTALINS LNNNKNTNSS PSSASSSPTT NNVAGGNNSP SSPGGSRKPP
PPLPPRPTVR SKTIASVNSP SERSTGGVIQ FASVVGGNNN LSGGGRSSVG GQVDDVTSGS
SLSINVGKGI SNNSNNSTSS FVKSTLNIGS KLFSNGKSKE KAQSPQVLTI LHKIPPPKPT
EPTTSSATTP VSTPTSEPKS EEKKDDENDI ATKSTHAFKL DLDRVLTPTQ EEPNNPPSSA
HSEKLSTCDE SDDEEEEEEE EGSIKSFNRS GKSAPPPIPQ KKIKTAEEKE IERRELRWEV
IAEISKTEEN YVEGMNHLER FYIKPLRALG NATQVSGSKQ IITQKDLSFI FDKMTVIKSV
NEGFLKQWKT LDVTFETQDD TSKSIGLFFK RTMPMFKVYT DYVNNYNNIA SKVKDMMKEN
PGFDSYMNEM ERNARKQGKV GFFSYMIQPV QRLPRYTLLL NELLKHTPET HYDFKNINEA
LELSKQVSSH VNSAMNVVQN QMKMNEIDTT IGKLHENIGG SIIKPSRCFV MEGEDFLVSE
IVLGRKIKKG DKRTLILLND MVLIAKKGKY SCHINFKNEM NVEYFKYPWI YFDLDYDKQS
FEIVTEDVTY LITCPTAIAC NEWIDKLSQN TSCNAGPVKE LRANKLVHTR VKKIFNEQNV
YIIDFENSEY YMCYSQRDKV TIKIPKKDAV VRDIVPEDEI TFGSLALDDD ASCDDSKTTA
SSDTADTASS QMVDGNRMSR STSISDLSTI SEDGSSLKSP RSARGFNPLK ALNMDLKIFN
GKKQSPSNSK NNLSSEDKVK NIHSSLSEIA SAGEMMPPSN RLSLQNDQHT KTSPFLNKNR
QSLSAFEQAN SGENSPANPE EFMGNQIARR TSDFQQTIEE RKKTLIRREA PPIPQGNNTT
ATQQQKAPWL AELESKRMAK VSKQEEQ
//
