ID D2VH29_NAEGR Unreviewed; 712 AA.
AC D2VH29;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Myosin {ECO:0000313|EMBL:EFC43817.1};
DE Flags: Fragment;
GN ORFNames=NAEGRDRAFT_33960 {ECO:0000313|EMBL:EFC43817.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC43817.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC43817.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; GG738871; EFC43817.1; -; Genomic_DNA.
DR RefSeq; XP_002676561.1; XM_002676515.1.
DR AlphaFoldDB; D2VH29; -.
DR STRING; 5762.D2VH29; -.
DR EnsemblProtists; EFC43817; EFC43817; NAEGRDRAFT_33960.
DR GeneID; 8850065; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_33960; -.
DR eggNOG; KOG0164; Eukaryota.
DR InParanoid; D2VH29; -.
DR OMA; MITARRI; -.
DR OrthoDB; 1094820at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd00124; MYSc; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF679; UNCONVENTIONAL MYOSIN IC; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671}.
FT DOMAIN 20..712
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 595..617
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT BINDING 124..131
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT NON_TER 712
FT /evidence="ECO:0000313|EMBL:EFC43817.1"
SQ SEQUENCE 712 AA; 82144 MW; 0519FA23299B1EC5 CRC64;
MSSTPRSDRS LDGDSPITEY SIDDVTFLDR PTTDNITNLL ESRYNKKDQS QKKSPQVYTY
LGDALIFVNP NDIKETEGLY KNSVMHFYHK KLPFARAPHI FSIAENAFRT MKETRQPQTI
IVNGESGSGK TESSKLILKY LTVVSQNGPS SYFVKHVLTE SNQLLEAFGN AKTLHCDNSS
RFGKYTTVYF GFGDRIEGGK ISTILLEKSH ITNQRKKERN FHIFYQLCRG ADRSMKEEFN
LHDPSEFLYL NSTETVIDGV DDMREFKKTI KSMDSIGFSS NDRKEIFRVV AGILHLGNIQ
FLEGNSKDRA EIVENDALKW ASLCLGVQPN QLKHALLART LNTEEKVVTF QTAVQARFNR
DALAKGIYER LFLWIVQKIN SVIKPKTKKM VTKIGILDLY GFEIYPSDNS LEQLNINFVN
EKLQQHTLKL LQQEKDEYVK EGIFNMDLFT ILSKELKKDF LSDFDTINDC ISCIEDKPLG
IYSLLDEEDY LNVSGDERYL AKLKENLKKS NSFEPARFKS TTFSLKHFAA KVDYNVTDWV
KKNKDTLFKD LIDAMCKSSS DLVQELFKPL DDFYSGRESK RRLQETIVKQ FKRDVNKLMN
KKLKGKIHFI YCIKPNYEKK ALKFDKKLIT NQVKCLGLSS ISIFKQHGFF FKMDYPKFFA
KYKALSPKTW PSSSADFDIE ELKSKIRSIL AETKIESNNY AFGKTEIFLK TP
//
