ID D2VNB8_NAEGR Unreviewed; 390 AA.
AC D2VNB8;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=BLUF domain-containing soluble adenylate/guanylate cyclase {ECO:0000313|EMBL:EFC41628.1};
GN ORFNames=NAEGRDRAFT_70440 {ECO:0000313|EMBL:EFC41628.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC41628.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC41628.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
CC -!- SUBUNIT: Heterotetramer of two alpha and two beta subunits.
CC {ECO:0000256|ARBA:ARBA00011103}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000256|ARBA:ARBA00004230}.
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DR EMBL; GG738884; EFC41628.1; -; Genomic_DNA.
DR RefSeq; XP_002674372.1; XM_002674326.1.
DR AlphaFoldDB; D2VNB8; -.
DR SMR; D2VNB8; -.
DR EnsemblProtists; EFC41628; EFC41628; NAEGRDRAFT_70440.
DR GeneID; 8851263; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_70440; -.
DR eggNOG; KOG4171; Eukaryota.
DR InParanoid; D2VNB8; -.
DR OrthoDB; 5473172at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0009882; F:blue light photoreceptor activity; IEA:InterPro.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR036046; Acylphosphatase-like_dom_sf.
DR InterPro; IPR007024; BLUF_domain.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR47455; ADENYLYL CYCLASE BETA; 1.
DR PANTHER; PTHR47455:SF1; GUANYLATE CYCLASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF04940; BLUF; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SMART; SM01034; BLUF; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF54975; Acylphosphatase/BLUF domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50925; BLUF; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Flagellum {ECO:0000256|ARBA:ARBA00022846};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 11..106
FT /note="BLUF"
FT /evidence="ECO:0000259|PROSITE:PS50925"
FT DOMAIN 188..320
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 390 AA; 44092 MW; 2872A0D7CC61B9C3 CRC64;
MSSIQEQSPQ YTRVQYVSLS TQGVITEKIK SQILASSNKN NSKRHITGCL ICVKDMFFQI
IEGKTDDVEN LYTTIVKDKR HNNVVCVDKS QFFNEEERMF PSWDMKSLDV DSLFSAKKEV
LICGENCNPL DPAHKRVIET AFSAFTTLMG SLFRAQQVFK NYAQPSVSRF VREGLNPLCI
QSVETEKIVL FVDLVNYTTL TEIISQSRSA SEIVRILNVF FTIVMEIVEE YGGDITKLIG
DCVMCHFDGH DSQKAIDCSL KILQQLELLR NETTDPFEKL IFCTIGISKG KVILGNVGTV
GRKLDYTVIG DSVNTSARLQ SFASSTQYYL IFDENVKNDL ESGDSVIFCG SIELKGKRNT
VNAYTIENEY NRRLLKEDLK ALYCSVSLEM
//
