ID D2VS50_NAEGR Unreviewed; 644 AA.
AC D2VS50;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=C2 domain-containing protein {ECO:0000313|EMBL:EFC40364.1};
GN ORFNames=NAEGRDRAFT_59068 {ECO:0000313|EMBL:EFC40364.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC40364.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC40364.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
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DR EMBL; GG738893; EFC40364.1; -; Genomic_DNA.
DR RefSeq; XP_002673108.1; XM_002673062.1.
DR AlphaFoldDB; D2VS50; -.
DR EnsemblProtists; EFC40364; EFC40364; NAEGRDRAFT_59068.
DR GeneID; 8854711; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_59068; -.
DR InParanoid; D2VS50; -.
DR OrthoDB; 5481236at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR CDD; cd00030; C2; 1.
DR Gene3D; 1.20.5.110; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR010989; SNARE.
DR InterPro; IPR000727; T_SNARE_dom.
DR Pfam; PF00168; C2; 1.
DR SMART; SM00239; C2; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF47661; t-snare proteins; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50192; T_SNARE; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671}.
FT DOMAIN 25..142
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 558..620
FT /note="T-SNARE coiled-coil homology"
FT /evidence="ECO:0000259|PROSITE:PS50192"
FT REGION 186..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 520..581
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 186..200
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..248
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 644 AA; 72983 MW; 00ECC13C4ED9A332 CRC64;
MFKSRTNHLH GLISEGEQNF LTQIKNGANN ANGNSPAEFF QLELTIEKVS IDASSLQQTN
QVEVSPYLMI KVNGVYKQRT KAKRNNLNPS FNQTFLLGLE NPNRDIIQIY VHDKERNGET
IGFCTIDHLN QFNFGNITSL ELDLEAPSIA DLTRSSIFTD GICGSIQVDV KPLNFGATEK
EASKLGIGKK KKKGGAERNE SPDKSNTSSP VPGAVALTTA SNGDHHPKKK SDHKPHFDLP
PQEEEEHACP LDNDAAQKRK SRWFGADPLG TPTLESSFNF DDVNFQSANT TSMGEDHLFS
NSGPNLIQIE GEKEFTKTKQ QFKLLYVMAM DIQMFGEKVN KLEALLSKWE HFENDTEKIR
NSIQSCISKA EKKRELLDKF IPKLSKKLPQ VTNCKLTIMK LTKLKIQFEN IDKQYQNFLK
KRQKIERHHK KKRSERMLEF DELMDHVLYQ TGASTTQQTS KKSKEKSLEI PSPTVATAKE
GKVDRNARKK EEQVMKKKQF MQAIMAGARD SGATNPDHLV RKYEEKQMEL QHKKEQDQQQ
KIQFILSTAD AETIEMEKKI ALETKAELEA VEKDYAELHE MYEQMNFLIR EQGQGLNIIE
KNIQQANEYV KEGTEYVKAA SACTTTGILT GGFTKAAVLK KLIS
//
