ID   D2VTJ8_NAEGR            Unreviewed;      1258 AA.
AC   D2VTJ8;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   27-MAR-2024, entry version 54.
DE   SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC39873.1};
GN   ORFNames=NAEGRDRAFT_52133 {ECO:0000313|EMBL:EFC39873.1};
OS   Naegleria gruberi (Amoeba).
OC   Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC   Vahlkampfiidae; Naegleria.
OX   NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN   [1] {ECO:0000313|EMBL:EFC39873.1, ECO:0000313|Proteomes:UP000006671}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEG-M {ECO:0000313|EMBL:EFC39873.1,
RC   ECO:0000313|Proteomes:UP000006671};
RX   PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA   Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA   Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA   Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA   Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT   "The genome of Naegleria gruberi illuminates early eukaryotic
RT   versatility.";
RL   Cell 140:631-642(2010).
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DR   EMBL; GG738896; EFC39873.1; -; Genomic_DNA.
DR   RefSeq; XP_002672617.1; XM_002672571.1.
DR   AlphaFoldDB; D2VTJ8; -.
DR   STRING; 5762.D2VTJ8; -.
DR   EnsemblProtists; EFC39873; EFC39873; NAEGRDRAFT_52133.
DR   GeneID; 8854478; -.
DR   VEuPathDB; AmoebaDB:NAEGRDRAFT_52133; -.
DR   eggNOG; KOG0192; Eukaryota.
DR   InParanoid; D2VTJ8; -.
DR   OrthoDB; 1614410at2759; -.
DR   Proteomes; UP000006671; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   CDD; cd13999; STKc_MAP3K-like; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   PANTHER; PTHR23257; SERINE-THREONINE PROTEIN KINASE; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        844..871
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          963..1258
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          1..59
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          911..932
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7..59
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1258 AA;  142417 MW;  4B31E721829C05F1 CRC64;
     MNKAKNKAKK TQASTSFAKD VSQEGSSSPA KKVSQVSASY PSKQVSQEGS SPQNKEVSPT
     FKCECNTSIY NQIRNADTTT GIQLLVNTLV QFIDDINQDI ACIKQDIACI KQDIASIKKD
     LNNPNTNVGC LYELQVKNEF EKEYSHVEWP MILQRKQFPK QFFEVDANSS HYTNLCNELV
     ESKVMSLENA TVLDLFIGSV EINVVRKETQ SKNDTHIIEV TMSSFTNDCQ LICKLLQLER
     QALYYRACYP NDKITTIGLV SPSSLTIDRI KGINVIYFHS LKFQSLLIKY DNSKSRPLDI
     LIEDCEMVNV SIEEYRKSIR DDWAKYFIME NSKFISNIFP LKILYTNQVI IVKSQFNYML
     GVQFGHSVTI QESVILGHPS IISNLQTFRI TNSSLESVGI QSVENVDFIG VFFFESKLYQ
     TSISISQITG FSGNKWTFTD CISKRVENFA SIRSVESVLI ENILLESSGS ISNGMVPFIY
     LDSCNTVTML RNIIKKGVSF IQINYYYTVQ IVSSQFYNNA PLLIDRSSPI ETSQSRISII
     NSKFSGSVSR YGPVQINYCT NLNIYGCVFN DNIATVSGGA LFIGNLVHSS QIAESYFINN
     QVACEGIPNM EKCSGGAISY TNSENSNGIL IEKCNFRNNV ASRGGILYFG KNNAYIRVTN
     STMENNQAKL TGSIAYFNYK EERYFQMIDV NRKNNFSPTS IDLAEKISYN SASIMGISNE
     NDVYELSIGK KYSLNLTGTD GYGNQTNQVI DQLSIESSDS RLTMTLDQQL DSITFQLFFL
     DSAQNFSLLG FKNTFKITTP NNPVNLSIII KSCDTGFEIT STVTEKTGIY LYDCRPIPVF
     PIGILLGLVI GCSLFVFILG VSIGLASYCL WNVVKKLRKL RQKEIAEKQM EDALLNKRII
     FNMTEDEEEY YEKRPEAESG SKNSKASYQK LPDSELSSSL MNQNKTKHRY SMSSSFIIPI
     EDITIIKKIG EGGAANVYYG TWTNIKVAIK SLKSEINEDF EQNFEREASI LSNIRHPNVL
     TFYGVCLTDK SRYIVTEYME KGTLEKFIYE SRNRGMNIEL LKTILTLLCG ISNGMQYLHA
     LKPAVIHRDL KSSNILLDER NNPKVSDFGL VKVLGTNTMQ TQMTKAIGTI FFMESFMTDH
     PIDNKEAATK LDVYSFSILM WELFFRKSPY HHVKNTFKIP QLVCDGERPQ IPFSVGNQEE
     IREWLLESNG ESNSDVVIQC IDRYFSLVVK CWNHNPLERP LFSNIRQELE EILSSINH
//