ID D2VU95_NAEGR Unreviewed; 486 AA.
AC D2VU95;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC39651.1};
DE Flags: Fragment;
GN ORFNames=NAEGRDRAFT_88235 {ECO:0000313|EMBL:EFC39651.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC39651.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC39651.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the TFIIA subunit 1 family.
CC {ECO:0000256|ARBA:ARBA00010059}.
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DR EMBL; GG738898; EFC39651.1; -; Genomic_DNA.
DR RefSeq; XP_002672395.1; XM_002672349.1.
DR AlphaFoldDB; D2VU95; -.
DR STRING; 5762.D2VU95; -.
DR EnsemblProtists; EFC39651; EFC39651; NAEGRDRAFT_88235.
DR GeneID; 8855756; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_88235; -.
DR eggNOG; KOG2652; Eukaryota.
DR InParanoid; D2VU95; -.
DR OrthoDB; 9955at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0005672; C:transcription factor TFIIA complex; IEA:InterPro.
DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:InterPro.
DR CDD; cd07976; TFIIA_alpha_beta_like; 1.
DR Gene3D; 1.10.287.100; -; 1.
DR Gene3D; 2.30.18.10; Transcription factor IIA (TFIIA), beta-barrel domain; 1.
DR InterPro; IPR004855; TFIIA_asu/bsu.
DR InterPro; IPR009088; TFIIA_b-brl.
DR PANTHER; PTHR12694; TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1; 1.
DR PANTHER; PTHR12694:SF8; TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1; 1.
DR Pfam; PF03153; TFIIA; 2.
DR SMART; SM01371; TFIIA; 1.
DR SUPFAM; SSF47396; Transcription factor IIA (TFIIA), alpha-helical domain; 1.
DR SUPFAM; SSF50784; Transcription factor IIA (TFIIA), beta-barrel domain; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW Transcription {ECO:0000256|ARBA:ARBA00023163}.
FT REGION 57..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 187..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 345..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..155
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..368
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..390
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 393..415
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 486
FT /evidence="ECO:0000313|EMBL:EFC39651.1"
SQ SEQUENCE 486 AA; 51696 MW; C359F1B70BCC2122 CRC64;
MSSVSNHEKL VADFYRSLID EVAAGIQEIF VEEGYNSDVI NELKKLWGDK IGESGAVPAW
NITPGQSSSR GSNRGAAASR NAARSRNQNA AASSSNTAIP TQSSQLGTQS TQINQSQDIL
GGNHAPTLPI VAGTPSEFMP PQPRIPPPSF SNPNLGPPPG FSSGILSGAM PSLPSISPGL
PSISPLSSAH HHNISTPTNP LYNTPSNSSG GGILSSSTGG GILASGGGLS LPSLPAATTP
SSSTPNSIFS STISLPPPVT PIQSPYGMPN IPPPSFSTPK SDFMASSPYL HLEDLKVTCL
LSLLVQIQFW EEINLPSIQS PQFGQNSLPS IGSMLPPAYS PNPYGTPFSS SSIESPAYTS
PLDTNKRLRL DPNSNDARLG NNNNPNFRQY DGANDDDDED DEDDDSEEDE EEEEPSKSAA
STGEEELGSD DDVEDDKDPD TPNIILAQYE KVTRHKNRWK CTLKCGIMHL DGKDYLFNKL
TGDFEW
//
