ID D2VUK4_NAEGR Unreviewed; 944 AA.
AC D2VUK4;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Rho GTPase activating protein {ECO:0000313|EMBL:EFC39526.1};
GN ORFNames=NAEGRDRAFT_72695 {ECO:0000313|EMBL:EFC39526.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC39526.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC39526.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
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DR EMBL; GG738899; EFC39526.1; -; Genomic_DNA.
DR RefSeq; XP_002672270.1; XM_002672224.1.
DR AlphaFoldDB; D2VUK4; -.
DR STRING; 5762.D2VUK4; -.
DR EnsemblProtists; EFC39526; EFC39526; NAEGRDRAFT_72695.
DR GeneID; 8850894; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_72695; -.
DR eggNOG; KOG1453; Eukaryota.
DR InParanoid; D2VUK4; -.
DR OrthoDB; 5482290at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00159; RhoGAP; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR15228; SPERMATHECAL PHYSIOLOGY VARIANT; 1.
DR PANTHER; PTHR15228:SF25; SPERMATHECAL PHYSIOLOGY VARIANT; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000006671}.
FT DOMAIN 306..533
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 138..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 588..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 724..746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 830..855
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..153
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 944 AA; 108946 MW; 43EC01EAD93AE242 CRC64;
MSSNNLTKIR LYIELSPTDQ SNSVLHTKTF ELNGKKSKQT TFNDILLQLQ DDLQMIFPQN
SCFVMTTTSN ISSEMVVGLS DDTSDMSSVS NDASSSKHDR MKSFGANLVG MVYGGGKKRK
SIPGSFYYDK QDISEGLVSK NTSHQSTTSN DSDEMNDGEM KREFIKMKST VFSMKEYAHS
YHLISADNQP PTIDTLYLEL FPNCAPFKAK VFGNYLQTIC KNETLFNFHF LMKSLKTYNT
LNSNWIISEI ESRKKTPFTT LLSPLTVLSP QTLSLCANNV DLKNIDTLYA SLTDEERLHV
KEPTLYLLRD VKIPFVLRAC FHFLKSNDPS SQTPRVANEG IFRQAGSKVK IEKFMKKFNT
LLAFPTIFPN GIHFPPNTDA HLVADLIKRF LREMQDPLLS YEKYDEFIRL FEPHADVDGI
TQEASKDYFH VLESTKRLVH TLPQVNQAVL RELLSILRMA SIGEYANDTK MTPKTMAIVM
STNLMFVPQS SVAVVLDDFK RMSIRAHLQK QQQTLPIICQ VCRFLIENAE QIFPSQSSGS
SSVTTPRSSN RFSINLSALG NDEFSVMSSR RSAQFTSSMM QQLNSVINKS DSSDDNTQTA
SSESTQPTDN ALKLMEEHMK ELEDDYQQQI IILSQELEEL RKDISYKDEL IIELKKESFN
NLQKEDSVKN LTETLEIIQK EKAELEQQTN SLKSQIEEKE EHNKELSEFC ERLQLNLETR
EKELDEKSKQ LEKNSSQPTV DLKRSAEEEQ ERKLAIENRI AQVLQQEQIK WKQDVQELIS
IEREKWLLEM ENEKNLWNQK HEQTVEDVER NFNKQSSILK EEYEKALETL RNENQESERK
LQQKMEEELQ KQKQTLEKES ENKLIQQKAQ LETELAPLQE KVVNLTEEVL VKTKQFYHQA
LLNMKLVMSD NNFDIPELIE QAVNENVNEA DMNEWISKKL IFKK
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