ID   D2VYF8_NAEGR            Unreviewed;      1127 AA.
AC   D2VYF8;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   27-MAR-2024, entry version 42.
DE   SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC38051.1};
GN   ORFNames=NAEGRDRAFT_53252 {ECO:0000313|EMBL:EFC38051.1};
OS   Naegleria gruberi (Amoeba).
OC   Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC   Vahlkampfiidae; Naegleria.
OX   NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN   [1] {ECO:0000313|EMBL:EFC38051.1, ECO:0000313|Proteomes:UP000006671}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEG-M {ECO:0000313|EMBL:EFC38051.1,
RC   ECO:0000313|Proteomes:UP000006671};
RX   PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA   Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA   Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA   Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA   Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT   "The genome of Naegleria gruberi illuminates early eukaryotic
RT   versatility.";
RL   Cell 140:631-642(2010).
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DR   EMBL; GG738911; EFC38051.1; -; Genomic_DNA.
DR   RefSeq; XP_002670795.1; XM_002670749.1.
DR   AlphaFoldDB; D2VYF8; -.
DR   EnsemblProtists; EFC38051; EFC38051; NAEGRDRAFT_53252.
DR   GeneID; 8857946; -.
DR   VEuPathDB; AmoebaDB:NAEGRDRAFT_53252; -.
DR   InParanoid; D2VYF8; -.
DR   OrthoDB; 5523096at2759; -.
DR   Proteomes; UP000006671; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        341..368
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        733..757
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          850..988
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          151..175
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          194..233
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1127 AA;  128080 MW;  7F36CB3797E6A70E CRC64;
     MIHTTPSSGT SETSHYLLPN QGNENNRIFS SPSSLEYSLS SLGSHSPQFY HSPPTSPESL
     NLMENHNENH RLVQDQHEDL KYLDDNSGQH QYSMETGQSS ITTENHHNNC DSYEVSLNID
     DGHMNGHETD EFRVDTGIRS VLRRFSWLTL GSSSSTTPRS RHSIGLPTTN NLFSPPITET
     RKFSIGQKQH PNTAFVLMSP QSPRTTTPSP TTSSSSMAHE LEQQNHESVE TPVSSLVDQD
     IAQSGDVTPV QSNNYRANTY SPPPFTRTIS VVLNDITNSP VGVERRRRDS IASNKKVNER
     ANSIAYRTSN ITNLINNTSF HSTKKQLEKE KKRRGESCSK FCHSFFTISN ILMGIFILQA
     IVCLIFGISI MRAGGAILDV KIREYQFLQI RAFVEERISS FTSKYTTMTN HMMEGLKGIP
     INDNVALLRF FDYVAITFGT DTSLNRMEFY RMDDSFSMLR DFNNGKSVIS INSISNPSMF
     STYLWPKTLT FVENPNGYYA SSSDTSYSIY KNYMYGPILE LNEIFNNSAV LNNFILNNQE
     VFCKSLSSNI PSNYNNFKWV PSKSIQNSSI FLHYPVYISN NYNHTIVSPN TRKMFIVNSD
     QNLENSYLFG VFSLHFSIDR FTTLLNVQNE RFYLQSEYSS NTSFIMNTWG DILATRGDGN
     ESLHNIQLIY KTIMKHGLKK NCEVESEVID IPNTRLTARL SYTCDGHGLN LVLVVEMDNS
     DSFIPLLLAN NSILSFVASF LLIIVSIIVM IAVLRALNTS MERMSKKLHR ITRLKQRESE
     GGKSFSQIIS DFFPNTSMTV FYEVREIENL IMLLGQGMDA LKKFLPEPFV KEIILSKPLP
     FNVATKKHLT ILFCELAGCD KMADTIDIPL FLEMITEYSS IMCKIIQDHK GMIDRFDGGT
     AMCLFSFQDN TLIPTEQNQE VNACHAAMDI IYMMEDFKTK WQKRTGHPIH IEIGINSGEI
     YYGNFNCTDS RSSYSVLGAS LDIASTLQRF NFSYSTQVLI GEETFLKVKD IFVCYFVDLV
     RFSGYKKRRG MKIYSLECPV RESTDLERKI ALDLEQVQQK IMEKSYASAL SLCGQVMLFN
     DRPQVSYLHN RLSHAKEESE KVIPNDNDLF STVANFGIDP EEILSFL
//