ID D2VZP4_NAEGR Unreviewed; 820 AA.
AC D2VZP4;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC37695.1};
GN ORFNames=NAEGRDRAFT_53552 {ECO:0000313|EMBL:EFC37695.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC37695.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC37695.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
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DR EMBL; GG738915; EFC37695.1; -; Genomic_DNA.
DR RefSeq; XP_002670439.1; XM_002670393.1.
DR AlphaFoldDB; D2VZP4; -.
DR STRING; 5762.D2VZP4; -.
DR EnsemblProtists; EFC37695; EFC37695; NAEGRDRAFT_53552.
DR GeneID; 8853606; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_53552; -.
DR eggNOG; KOG0575; Eukaryota.
DR InParanoid; D2VZP4; -.
DR OMA; KKSKNHA; -.
DR OrthoDB; 5471704at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd13118; POLO_box_1; 1.
DR CDD; cd13117; POLO_box_2; 1.
DR CDD; cd14099; STKc_PLK; 1.
DR Gene3D; 3.30.1120.30; POLO box domain; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR033701; POLO_box_1.
DR InterPro; IPR033695; POLO_box_2.
DR InterPro; IPR000959; POLO_box_dom.
DR InterPro; IPR036947; POLO_box_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR24345; SERINE/THREONINE-PROTEIN KINASE PLK; 1.
DR PANTHER; PTHR24345:SF0; SERINE_THREONINE-PROTEIN KINASE PLK1; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00659; POLO_box; 2.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF82615; Polo-box domain; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50078; POLO_BOX; 2.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 90..344
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 613..683
FT /note="POLO box"
FT /evidence="ECO:0000259|PROSITE:PS50078"
FT DOMAIN 734..801
FT /note="POLO box"
FT /evidence="ECO:0000259|PROSITE:PS50078"
FT REGION 1..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 418..584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 430..533
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..548
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 820 AA; 92918 MW; 29EC99662052F0F4 CRC64;
MYSTRSATPQ TSYRLPGSSS TTTSSGTSNA AAQKLTRPAT ASGVTATRRT PTPTVSQNKL
QPTSSTPRII IEEKYHKKVD KDRQVLYRKY YQERFLGKGG FAQCYLFRQV GTNIFHAAKI
IDKKTLEKEN VKQKLFSEIK IHSSLSHRHI VNFVRYFEDI NNVYILLEVC NCGSMMDLLK
SRTRLTEQEA RFFLHQILLA CLYMNEKKVI HRDLKLGNLF LTDKMEIKIG DFGLATEVEF
DGERKKTICG TPNYIAPEIL YNKGHSFEVD IWSIGVILYT MLVGTPPFET KDVKETYKKI
KHNDYNFPPD IEISSKAKSL IRSILRRNPD DRPDIKTILS DPFFAGHSVD VCPVTLLEYA
RTHALKIPDV EETMPGYSLK HPELQQQMLK LRQDRGALRQ IDNNTMHQRA QPTVETGLKK
PLMSGFPTST MRPPLATVNT NINNENYNPN SQQVVTKQPL FTPSHPPQQQ TEQPQKPVHP
TLQTHYTSTT TTQSVSTTNS PSHVTASSVT SSPSLGSQRS VQTTQTTSRL PTPKRRSPSE
DERKSKPQTP TSESSLETSR SKGPPVKKVR NTVSSPYSPY DVLDPMTVDE DDTTNDNVTH
DLPPIWITHW ADFSAKYGLT YLMSNGCVGA VYNDSSKMTY MPATEQINYY ERKATGDNIY
EERSTFTVSD FPPQMNKKVT LIKYFADVLS KLKRNDHNLV SSPNSDTGRC SYRPKDDVFI
QKTGLDDVFV KRWLRTSHAV IFRLSNKIVQ VCFHDQTEII LTGDSNLVSY TDPQGVRTTY
ALNKVVKSPS QEIAKRLKYT KDVLCQLISG SATTDKHRNQ
//
