ID   D2W029_NAEGR            Unreviewed;      1363 AA.
AC   D2W029;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   27-MAR-2024, entry version 51.
DE   SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC37501.1};
GN   ORFNames=NAEGRDRAFT_74709 {ECO:0000313|EMBL:EFC37501.1};
OS   Naegleria gruberi (Amoeba).
OC   Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC   Vahlkampfiidae; Naegleria.
OX   NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN   [1] {ECO:0000313|EMBL:EFC37501.1, ECO:0000313|Proteomes:UP000006671}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEG-M {ECO:0000313|EMBL:EFC37501.1,
RC   ECO:0000313|Proteomes:UP000006671};
RX   PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA   Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA   Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA   Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA   Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT   "The genome of Naegleria gruberi illuminates early eukaryotic
RT   versatility.";
RL   Cell 140:631-642(2010).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GG738917; EFC37501.1; -; Genomic_DNA.
DR   RefSeq; XP_002670245.1; XM_002670199.1.
DR   STRING; 5762.D2W029; -.
DR   EnsemblProtists; EFC37501; EFC37501; NAEGRDRAFT_74709.
DR   GeneID; 8857425; -.
DR   VEuPathDB; AmoebaDB:NAEGRDRAFT_74709; -.
DR   eggNOG; KOG4659; Eukaryota.
DR   InParanoid; D2W029; -.
DR   OrthoDB; 5480194at2759; -.
DR   Proteomes; UP000006671; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   CDD; cd00054; EGF_CA; 2.
DR   Gene3D; 2.10.25.10; Laminin; 2.
DR   Gene3D; 2.120.10.30; TolB, C-terminal domain; 6.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR013111; EGF_extracell.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR001258; NHL_repeat.
DR   PANTHER; PTHR46388; NHL REPEAT-CONTAINING PROTEIN 2; 1.
DR   PANTHER; PTHR46388:SF2; NHL REPEAT-CONTAINING PROTEIN 2; 1.
DR   Pfam; PF07974; EGF_2; 1.
DR   SMART; SM00181; EGF; 3.
DR   SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR   SUPFAM; SSF101898; NHL repeat; 2.
DR   PROSITE; PS00022; EGF_1; 2.
DR   PROSITE; PS01186; EGF_2; 2.
DR   PROSITE; PS50026; EGF_3; 1.
DR   PROSITE; PS51125; NHL; 1.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        7..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          359..393
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   REPEAT          405..436
FT                   /note="NHL"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT   DISULFID        383..392
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ   SEQUENCE   1363 AA;  141600 MW;  375092AF2AD9DECE CRC64;
     MVTKANISIV VIVVMMAMLV YMVNGAPLNT YSVKISTFAG GNGEFKDPQK LARLSNGDIL
     VSDALGHAIK KINVTSGVIT TIAGNGTAGF GGDNGPAVNA LVNKPFGIAV SQTDEIYFAD
     SGNNRIRKID LTGTITTVVG TGDATPFIDG DLATNCTINT PMDVSLSTSG ELYIADMYNY
     RIRKVLTNGT IVTFAGSGQS GHTGDGGLAT NAAMALAYGV KVFSNGEVYI SDSFNFKVRK
     VDVNGTITTV AGSGVAPYSG DNILATAANL NYPSDVFRFD TGELVIADTN NNRIRLVMPN
     GTIITTAGNG TASFSDGEFA EENGLSLPTG LVLIQNGLLI ADAGNKRIRL LQRTIFSCYG
     KSTLDSNVCS GQGRCVGNNI CQCNAGFEGP TCLPSKYYIT TVATDFKDPQ KIAKLSNGDI
     IVSDTGDHSI KKISYSTGVI SRIAGTGVAG FSGDGGLASQ AQLNKPYGIA ITANDEIYIA
     DNLNHRIRFV DVNGNISTVA GTSIGFSGDS GLATAAKLNA PMDVSLSASG DLYIADRDNY
     RIRRVSSGVI STFAGNGQSG YSGDGGQATS AALSQAYGVK VINGEVYISD SNNYKVRKVD
     GSGIITTIAG SGAAPFNGDG LMATSSNMNH PTDVALLPSG EMIIADTDNY RIRMVLLNGT
     MVTIAGNGNY VSSGDYGLAT SAGLKLPTGI LITQDGIMFT ETSSVGSNGG GKVRLLSTVY
     VPPLCNGMSA SDPYVCNGRG SCIGKDLCQC NAGFNGTFCA NSQCVKPSAD ITIPCFGNGN
     CSNDVCTCAP GFYGPYCSIS VMISSRGYTH PIMGIFMMAT VNSLTLDGIS NVDYSWSQIS
     GPTISNLATM TNLKTPTFII PGKFNSLSFD NGLVSGNTYG FALTAKITTG AYTTTVTTST
     TVLVQQNPAL TFTLKDDSTN QAITSGVAGT TVFRINITSN SNPYSDSSFK YGFGFADSNS
     ITILTDMKEG PATFKLPFIS GQSSVDIYVG CEGTNSYSVQ KLTTVSLTNP VSNLPTSQAI
     SSIQNLFTSN SSVGDLLGAA SLLNTITTTD ATQIANKQTI RNSIITTISK AISTGDLGSA
     IKALSTVTSV TSEITQTSAD NTLETMISGT NNPQFSRNEV ASLVNIASSI GSVSSGSKTV
     SLGNSIGSKL ITQMSLGDLI SSSGANFGIA ISRGVKSFAL ANVSIALPSN TRSLNGIECF
     FIDIKDQLSF MQCLANSNWV ARNGPKYAPG TQRALNAATY TIGSLVYDLT PMYDNGTIVS
     GNVTSSTDIQ ITIPYTGSLT PVCGILNSDQ TYSVNSKATL VKGNGSVTCK TKVLRGNVLL
     LTQATAASSP ITPKKSTIVG GSETNKLSAL LMCLLMAISM LLF
//