ID D2W0W7_NAEGR Unreviewed; 698 AA.
AC D2W0W7;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC37252.1};
GN ORFNames=NAEGRDRAFT_81967 {ECO:0000313|EMBL:EFC37252.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC37252.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC37252.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
CC -!- SIMILARITY: Belongs to the cullin family.
CC {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC ECO:0000256|RuleBase:RU003829}.
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DR EMBL; GG738920; EFC37252.1; -; Genomic_DNA.
DR RefSeq; XP_002669996.1; XM_002669950.1.
DR AlphaFoldDB; D2W0W7; -.
DR STRING; 5762.D2W0W7; -.
DR EnsemblProtists; EFC37252; EFC37252; NAEGRDRAFT_81967.
DR GeneID; 8856856; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_81967; -.
DR eggNOG; KOG2166; Eukaryota.
DR InParanoid; D2W0W7; -.
DR OMA; GQEFETH; -.
DR OrthoDB; 21270at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR019559; Cullin_neddylation_domain.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11932; CULLIN; 1.
DR PANTHER; PTHR11932:SF126; CULLIN 4, ISOFORM A; 1.
DR Pfam; PF00888; Cullin; 1.
DR Pfam; PF10557; Cullin_Nedd8; 1.
DR SMART; SM00182; CULLIN; 1.
DR SMART; SM00884; Cullin_Nedd8; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF74788; Cullin repeat-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000006671}.
FT DOMAIN 396..547
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
SQ SEQUENCE 698 AA; 82066 MW; F5899C3769BD6854 CRC64;
MRKVQTGKKF EIKAPRAEST TTEAFFSTTW TLLKQAIQQI YHNKSSELSY EELYRNTYKI
VLNRHGESLY ENVEACMLEQ VEFILSSVLK KCPDELFLKT ICNVWEEYKT ETSVVSSVLM
YLNTNYALKQ LQQQQSQSSG NGANQTPVKH TLFVYDNGVE IFKRVVIYQS QSGVKIKNIV
IEMIGKERGG EYVDRLLLKK VVRMLCEMNC YNDVLEEPFL ETSAQYYLQL SRDLLAQTSI
TDYLKLVDER LREEDNRVQY YLSFTTKPKI SKILRQEMIT KHLDTITESP SGYISFLKDD
KISELHRMYN LFLGNEEEHL SIMIKLYKQY ITDVGIAYVM DEEKLQGSAV TFIEGLLEQK
RKYDRITRES FKSNSKFEQA QKEGFSIFSD GTRQKRVSEY LSLYLDNTIR TLGDSEQELE
PIMEDAMALF RFLRDKDIFE NYYKVHLSKR LLSKGHQANS EKMFILKMKK ECGYSFTSKI
EGMFNDMKIS AQTNEQYQQH DAFKLKPERM DFNVNILTHS FWPAYTLNNI ILPADLNLCC
ESFAKFYNHI KELTQIPEKD LKKTLTILCM NKTKILSKEP KTKNLEDNHK FVLNQDFKNA
NYRVRLAITS TKETVEEVQE TESKIELERK PVIEAVIVRV MKARKKLHHN ELMSEVVKQL
QSRFVPNPQE VKRRIENLIE RDFLSREVED HKTYNYVA
//
