ID   D2W421_NAEGR            Unreviewed;       813 AA.
AC   D2W421;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   27-MAR-2024, entry version 43.
DE   SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC36184.1};
GN   ORFNames=NAEGRDRAFT_76151 {ECO:0000313|EMBL:EFC36184.1};
OS   Naegleria gruberi (Amoeba).
OC   Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC   Vahlkampfiidae; Naegleria.
OX   NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN   [1] {ECO:0000313|EMBL:EFC36184.1, ECO:0000313|Proteomes:UP000006671}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEG-M {ECO:0000313|EMBL:EFC36184.1,
RC   ECO:0000313|Proteomes:UP000006671};
RX   PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA   Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA   Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA   Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA   Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT   "The genome of Naegleria gruberi illuminates early eukaryotic
RT   versatility.";
RL   Cell 140:631-642(2010).
CC   -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC       family. {ECO:0000256|ARBA:ARBA00029447}.
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DR   EMBL; GG738936; EFC36184.1; -; Genomic_DNA.
DR   RefSeq; XP_002668928.1; XM_002668882.1.
DR   AlphaFoldDB; D2W421; -.
DR   EnsemblProtists; EFC36184; EFC36184; NAEGRDRAFT_76151.
DR   GeneID; 8860870; -.
DR   VEuPathDB; AmoebaDB:NAEGRDRAFT_76151; -.
DR   InParanoid; D2W421; -.
DR   OrthoDB; 5519097at2759; -.
DR   Proteomes; UP000006671; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd06225; HAMP; 1.
DR   Gene3D; 6.10.340.10; -; 1.
DR   InterPro; IPR007892; CHASE4.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR016137; RGS.
DR   PANTHER; PTHR32089:SF112; HEME-BASED AEROTACTIC TRANSDUCER HEMAT; 1.
DR   PANTHER; PTHR32089; METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB; 1.
DR   Pfam; PF05228; CHASE4; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   SMART; SM00304; HAMP; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        39..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        396..421
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          423..477
FT                   /note="HAMP"
FT                   /evidence="ECO:0000259|PROSITE:PS50885"
FT   DOMAIN          640..756
FT                   /note="RGS"
FT                   /evidence="ECO:0000259|PROSITE:PS50132"
FT   REGION          784..813
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        784..806
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   813 AA;  92355 MW;  9D1EDC0735C077B1 CRC64;
     MKIELKEIAN LTFKYNAPDT TQQQENIFKK HSSLRLKTIS VLVVMFILLV CFCLAILLTS
     FFLIFHNVER VESTQSSRRV SRALFDDLKL LSDRTFEYGS FDSTTELVNG ASQETIDQYM
     SDYMNCDYLN RVNVNMALFY YLNGTMLRGI HCFKGVSIEG LPSELTNLDQ ETVDGQSNEY
     RKFFINNLEN PSTRHIGLMI PSKKLSELAT SETSQQAVSN YSSILSNVLL VNAMPIQGYD
     SLESFGMLTF AKYNTYDYLL DISERTQFCV TTYDLKSEYE TSAFKLSTSN AISDSLDAIT
     SEWIPTNISS TNVYSDWTND AASLVKVIDI GKSSSNSDYI LHGRQCSKTI TNKFSSFSAG
     SQNERMAAYQ MYNDITGGKT VVFRTDIQRS SFQVGMASFL VVWFVMTFFV LVLSAGVVIF
     IESSVLRRIL KLSKSVRDFY ESGNDFNKTI PQLGHDEIGT LSSKINQMLA SLKKNQEKLV
     SDMDTMQEML ERTSIQEQSN RCIMNSINEF IAIVEKSTGL IVNTNSYFDN KLVDSNENQQ
     QVNYLHDTID KFFKETPLDE LLQKFAEISD NGIWKTNIFS ITSKQLPVQL KVYNVRLLIK
     EGQVSDAFVI VAINLSEENE LQQSLQDQET KLEEMKKILD FNRIISDDYL KSRFLQLCPI
     PNASKYMAMI EKLETYKLTN KPQQRAKLHK KIVESYLIDQ NNISNLSDFP RSSIQTFNTE
     AKKAISSLAH FDVFEKIEVI VKLILINLAY TSFMENIKTI LSEKPSSRES TMSSTSSSFS
     LGFEIAQPGT SSSTDDEQSV KSGSAQDGNM YWM
//