ID D3E009_METRM Unreviewed; 683 AA.
AC D3E009;
DT 23-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 23-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Formate dehydrogenase alpha subunit FdhA1 {ECO:0000313|EMBL:ADC46185.1};
DE EC=1.2.1.2 {ECO:0000313|EMBL:ADC46185.1};
GN Name=fdhA1 {ECO:0000313|EMBL:ADC46185.1};
GN OrderedLocusNames=mru_0333 {ECO:0000313|EMBL:ADC46185.1};
OS Methanobrevibacter ruminantium (strain ATCC 35063 / DSM 1093 / JCM 13430 /
OS OCM 146 / M1) (Methanobacterium ruminantium).
OC Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC Methanobacteriales; Methanobacteriaceae; Methanobrevibacter.
OX NCBI_TaxID=634498 {ECO:0000313|EMBL:ADC46185.1, ECO:0000313|Proteomes:UP000008680};
RN [1] {ECO:0000313|EMBL:ADC46185.1, ECO:0000313|Proteomes:UP000008680}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35063 / DSM 1093 / JCM 13430 / OCM 146 / M1
RC {ECO:0000313|Proteomes:UP000008680};
RX PubMed=20126622; DOI=10.1371/journal.pone.0008926;
RA Leahy S.C., Kelly W.J., Altermann E., Ronimus R.S., Yeoman C.J.,
RA Pacheco D.M., Li D., Kong Z., McTavish S., Sang C., Lambie S.C.,
RA Janssen P.H., Dey D., Attwood G.T.;
RT "The genome sequence of the rumen methanogen Methanobrevibacter ruminantium
RT reveals new possibilities for controlling ruminant methane emissions.";
RL PLoS ONE 5:E8926-E8926(2010).
CC -!- COFACTOR:
CC Name=Mo-bis(molybdopterin guanine dinucleotide);
CC Xref=ChEBI:CHEBI:60539; Evidence={ECO:0000256|ARBA:ARBA00001942};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; CP001719; ADC46185.1; -; Genomic_DNA.
DR RefSeq; WP_012955141.1; NC_013790.1.
DR AlphaFoldDB; D3E009; -.
DR STRING; 634498.mru_0333; -.
DR GeneID; 8769973; -.
DR KEGG; mru:mru_0333; -.
DR PATRIC; fig|634498.28.peg.338; -.
DR eggNOG; arCOG01492; Archaea.
DR HOGENOM; CLU_000422_4_0_2; -.
DR OrthoDB; 23466at2157; -.
DR Proteomes; UP000008680; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0008863; F:formate dehydrogenase (NAD+) activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043546; F:molybdopterin cofactor binding; IEA:InterPro.
DR GO; GO:0015942; P:formate metabolic process; IEA:InterPro.
DR CDD; cd02753; MopB_Formate-Dh-H; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.40.50.740; -; 1.
DR Gene3D; 2.20.25.90; ADC-like domains; 1.
DR Gene3D; 3.40.228.10; Dimethylsulfoxide Reductase, domain 2; 1.
DR InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR InterPro; IPR041924; Formate_Dh-H_N.
DR InterPro; IPR006478; Formate_DH_asu.
DR InterPro; IPR006657; MoPterin_dinucl-bd_dom.
DR InterPro; IPR006656; Mopterin_OxRdtase.
DR InterPro; IPR006963; Mopterin_OxRdtase_4Fe-4S_dom.
DR NCBIfam; TIGR01591; Fdh-alpha; 1.
DR PANTHER; PTHR43105:SF15; FORMATE DEHYDROGENASE H; 1.
DR PANTHER; PTHR43105; RESPIRATORY NITRATE REDUCTASE; 1.
DR Pfam; PF04879; Molybdop_Fe4S4; 1.
DR Pfam; PF00384; Molybdopterin; 1.
DR Pfam; PF01568; Molydop_binding; 1.
DR SMART; SM00926; Molybdop_Fe4S4; 1.
DR SUPFAM; SSF50692; ADC-like; 1.
DR SUPFAM; SSF53706; Formate dehydrogenase/DMSO reductase, domains 1-3; 1.
DR PROSITE; PS51669; 4FE4S_MOW_BIS_MGD; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000313|EMBL:ADC46185.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008680}.
FT DOMAIN 4..60
FT /note="4Fe-4S Mo/W bis-MGD-type"
FT /evidence="ECO:0000259|PROSITE:PS51669"
SQ SEQUENCE 683 AA; 75802 MW; E3F328758D242714 CRC64;
MVEIKYVPSI CPYCGTGCGI NFVVKDGKII GVEPWKRHPV NEGKVCPKGN FGYQFINHPD
RLTTPLIKEN GEFREASWDE ALDLVASTLK KYADTDPNKL GFYACARSPN ENIYITQKLA
RAGCGTQNVD HCARICHGPT VAGLATTFGS GASTNGYDSI EEADFIFCIG SNNMEAHPLF
GRKIIRAIKN GAKLVVADPR FTPTAKLAHE YMQFKTGTDV ALMNGMIKII IENGLQDDEF
IKNRTKGYEE MKEVAMKYDL DKVAEITEAD PEQIERVALE YAQAENAAIV YSLGITEHSH
GADNVMSTAN LAMLTGNVGK IGGGVNPLRG QNNVQGACDM GALPSDYVGY QKVANPEITK
KFSDAYQIEL PTTPGLTLVE MMNAAHSGDL KVLYIHGEDP VLSDADIKHT KEAIANLEML
IVQELFMTDT AAEADVVLPA AGWGEQEGTF TSGERRVQWL RKAQEPPEGT MLDWKIMEEI
AVRMGRPREL FHYENAAEIW EEIRELAPSY YGITHERLLK PEGVHWPCLD PEDPCEPLMH
KDKFAHPDGL GVFQALEHRG PVEVVDDEYP LLLTTTRILF HYHAAMTRRC ETLDKEVPTG
FIEINTEDAA ERGILNNEIV KAYSRRGEIE IPARVTDDIK KGIVNIPMHF TECAANMLTN
SDSFDPKCKM VELKACAIQV EKL
//