ID   D3EQE1_ATETH            Unreviewed;       327 AA.
AC   D3EQE1;
DT   23-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   23-MAR-2010, sequence version 1.
DT   27-MAR-2024, entry version 75.
DE   RecName: Full=Cobalamin biosynthesis protein CobD {ECO:0000256|HAMAP-Rule:MF_00024};
GN   Name=cobD {ECO:0000256|HAMAP-Rule:MF_00024};
GN   OrderedLocusNames=UCYN_10160 {ECO:0000313|EMBL:ADB95691.1};
OS   Atelocyanobacterium thalassa (isolate ALOHA).
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC   Chroococcales; Aphanothecaceae; Atelocyanobacterium;
OC   Candidatus Atelocyanobacterium thalassa.
OX   NCBI_TaxID=1453429 {ECO:0000313|Proteomes:UP000001405};
RN   [1] {ECO:0000313|EMBL:ADB95691.1, ECO:0000313|Proteomes:UP000001405}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ALOHA {ECO:0000313|Proteomes:UP000001405};
RX   PubMed=20173737; DOI=10.1038/nature08786;
RA   Tripp H.J., Bench S.R., Turk K.A., Foster R.A., Desany B.A., Niazi F.,
RA   Affourtit J.P., Zehr J.P.;
RT   "Metabolic streamlining in an open-ocean nitrogen-fixing cyanobacterium.";
RL   Nature 464:90-94(2010).
CC   -!- FUNCTION: Converts cobyric acid to cobinamide by the addition of
CC       aminopropanol on the F carboxylic group. {ECO:0000256|HAMAP-
CC       Rule:MF_00024}.
CC   -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004953, ECO:0000256|HAMAP-Rule:MF_00024}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC       ECO:0000256|HAMAP-Rule:MF_00024}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|HAMAP-Rule:MF_00024}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the CobD/CbiB family.
CC       {ECO:0000256|ARBA:ARBA00006263, ECO:0000256|HAMAP-Rule:MF_00024}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|HAMAP-Rule:MF_00024}.
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DR   EMBL; CP001842; ADB95691.1; -; Genomic_DNA.
DR   RefSeq; WP_012954378.1; NC_013771.1.
DR   AlphaFoldDB; D3EQE1; -.
DR   STRING; 1453429.UCYN_10160; -.
DR   KEGG; cyu:UCYN_10160; -.
DR   PATRIC; fig|713887.8.peg.947; -.
DR   HOGENOM; CLU_054212_0_0_3; -.
DR   OrthoDB; 9811967at2; -.
DR   UniPathway; UPA00148; -.
DR   Proteomes; UP000001405; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015420; F:ABC-type vitamin B12 transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0048472; F:threonine-phosphate decarboxylase activity; IEA:InterPro.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   HAMAP; MF_00024; CobD_CbiB; 1.
DR   InterPro; IPR004485; Cobalamin_biosynth_CobD/CbiB.
DR   NCBIfam; TIGR00380; cobal_cbiB; 1.
DR   PANTHER; PTHR34308; COBALAMIN BIOSYNTHESIS PROTEIN CBIB; 1.
DR   PANTHER; PTHR34308:SF1; COBALAMIN BIOSYNTHESIS PROTEIN CBIB; 1.
DR   Pfam; PF03186; CobD_Cbib; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475, ECO:0000256|HAMAP-
KW   Rule:MF_00024};
KW   Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573, ECO:0000256|HAMAP-
KW   Rule:MF_00024};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_00024};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001405};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW   Rule:MF_00024};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW   Rule:MF_00024}.
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00024"
FT   TRANSMEM        83..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00024"
SQ   SEQUENCE   327 AA;  36320 MW;  EB26A3504165AF8F CRC64;
     MNTDFSIIIL IVASLIDYLV SDPSKYLHPV QVMGWLIVKC SNFLLKSFKK RFMRRCTGIV
     LGLLLVVGSG VFGWMIGLIK YHFSPLIGVV IESIFLASCF AGRSLRLAAY DVFIPLNRKK
     INLARIKLSQ YVGRSTTHLS QKNIWRTVLE TISENSIDGV MAPLFYAIIG ALLPHTNSLA
     FALAYKASST LDSTIGYKKE PFADIGWFSA NLEDILTWIP CRLGVLTLAI LAGRPYYVFS
     VCNRDGTKDI SPNSGWSESV YAAILKVQLG GKNIYGDVVK DKPLLGEPIE SITFNTIEKA
     LTLKRMCSLC WLILGITLIY IKNSIST
//