ID D3GUQ2_ECO44 Unreviewed; 413 AA.
AC D3GUQ2;
DT 23-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 23-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Microcin H47 secretion protein {ECO:0000313|EMBL:CBG36021.1};
GN Name=mchE {ECO:0000313|EMBL:CBG36021.1};
GN OrderedLocusNames=EC042_3197 {ECO:0000313|EMBL:CBG36021.1};
OS Escherichia coli O44:H18 (strain 042 / EAEC).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=216592 {ECO:0000313|EMBL:CBG36021.1, ECO:0000313|Proteomes:UP000001407};
RN [1] {ECO:0000313|EMBL:CBG36021.1, ECO:0000313|Proteomes:UP000001407}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=042 / EAEC {ECO:0000313|Proteomes:UP000001407};
RX PubMed=20098708; DOI=10.1371/journal.pone.0008801;
RA Chaudhuri R.R., Sebaihia M., Hobman J.L., Webber M.A., Leyton D.L.,
RA Goldberg M.D., Cunningham A.F., Scott-Tucker A., Ferguson P.R.,
RA Thomas C.M., Frankel G., Tang C.M., Dudley E.G., Roberts I.S., Rasko D.A.,
RA Pallen M.J., Parkhill J., Nataro J.P., Thomson N.R., Henderson I.R.;
RT "Complete genome sequence and comparative metabolic profiling of the
RT prototypical enteroaggregative Escherichia coli strain 042.";
RL PLoS ONE 5:E8801-E8801(2010).
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
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DR EMBL; FN554766; CBG36021.1; -; Genomic_DNA.
DR AlphaFoldDB; D3GUQ2; -.
DR KEGG; elo:EC042_3197; -.
DR PATRIC; fig|216592.3.peg.3331; -.
DR HOGENOM; CLU_023976_4_0_6; -.
DR Proteomes; UP000001407; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 2.40.50.100; -; 1.
DR InterPro; IPR043602; CusB_dom_1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR006144; Secretion_HlyD_CS.
DR PANTHER; PTHR30386:SF27; EXPORTED PROTEIN-RELATED; 1.
DR PANTHER; PTHR30386; MEMBRANE FUSION SUBUNIT OF EMRAB-TOLC MULTIDRUG EFFLUX PUMP; 1.
DR Pfam; PF00529; CusB_dom_1; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR PRINTS; PR01490; RTXTOXIND.
DR PROSITE; PS00543; HLYD_FAMILY; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022519};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 36..386
FT /note="Cation efflux system protein CusB"
FT /evidence="ECO:0000259|Pfam:PF00529"
FT DOMAIN 188..317
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
SQ SEQUENCE 413 AA; 47330 MW; 9AEE2D2A90A601D5 CRC64;
MKWQGRAILL PGIPLWLIML GSIVFITAFL MFIIVGTYSR RVNVSGEVTT WPRAVNIYSG
VQGFVVRQFV HEGQLIKKGD PVYLIDISKS TRSGIVTDNH RRDIENQLVR VDNIISRLEE
SKKITLDTLE KQRLQYTDAF RRSSDIIQRA EEGIKIMKNN MENYRNYQAK GLINKDQLTN
QVALYYQQQN NLLSLSGQNE QNALQITTLE SQIQTQAADF DNRIYQMELQ RYELQKELVN
TDVEGEIIIR ALTDGKVDSL SVTVGQMVNT GDSLLQVIPE NIENYYLILW VPNDAVPYIS
AGDKVNIRYE AFPAEKFGQF SATVKTISRT PASTQEMLTY KGAPQNTPGA SVPWYKVIAM
PEKQIIRYDE KYLPLENGMK AESTLFLEKR RIYQWMLSPF YDMKHSATGP LND
//
