ID D3H1L3_ECO44 Unreviewed; 220 AA.
AC D3H1L3;
DT 23-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 23-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=3-keto-L-gulonate-6-phosphate decarboxylase {ECO:0000313|EMBL:CBG36710.1};
DE EC=4.1.1.85 {ECO:0000313|EMBL:CBG36710.1};
GN Name=sgbH {ECO:0000313|EMBL:CBG36710.1};
GN OrderedLocusNames=EC042_3887 {ECO:0000313|EMBL:CBG36710.1};
OS Escherichia coli O44:H18 (strain 042 / EAEC).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=216592 {ECO:0000313|EMBL:CBG36710.1, ECO:0000313|Proteomes:UP000001407};
RN [1] {ECO:0000313|EMBL:CBG36710.1, ECO:0000313|Proteomes:UP000001407}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=042 / EAEC {ECO:0000313|Proteomes:UP000001407};
RX PubMed=20098708; DOI=10.1371/journal.pone.0008801;
RA Chaudhuri R.R., Sebaihia M., Hobman J.L., Webber M.A., Leyton D.L.,
RA Goldberg M.D., Cunningham A.F., Scott-Tucker A., Ferguson P.R.,
RA Thomas C.M., Frankel G., Tang C.M., Dudley E.G., Roberts I.S., Rasko D.A.,
RA Pallen M.J., Parkhill J., Nataro J.P., Thomson N.R., Henderson I.R.;
RT "Complete genome sequence and comparative metabolic profiling of the
RT prototypical enteroaggregative Escherichia coli strain 042.";
RL PLoS ONE 5:E8801-E8801(2010).
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DR EMBL; FN554766; CBG36710.1; -; Genomic_DNA.
DR RefSeq; WP_000089510.1; NC_017626.1.
DR AlphaFoldDB; D3H1L3; -.
DR KEGG; elo:EC042_3887; -.
DR PATRIC; fig|216592.3.peg.4038; -.
DR HOGENOM; CLU_081825_0_0_6; -.
DR Proteomes; UP000001407; Chromosome.
DR GO; GO:0033982; F:3-dehydro-L-gulonate-6-phosphate decarboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:InterPro.
DR GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR CDD; cd04726; KGPDC_HPS; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR041710; HPS/KGPDC.
DR InterPro; IPR001754; OMPdeCOase_dom.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR PANTHER; PTHR35039; 3-KETO-L-GULONATE-6-PHOSPHATE DECARBOXYLASE SGBH-RELATED; 1.
DR PANTHER; PTHR35039:SF3; 3-KETO-L-GULONATE-6-PHOSPHATE DECARBOXYLASE SGBH-RELATED; 1.
DR Pfam; PF00215; OMPdecase; 1.
DR SMART; SM00934; OMPdecase; 1.
DR SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
PE 4: Predicted;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW Decarboxylase {ECO:0000256|ARBA:ARBA00022793};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:CBG36710.1}.
FT DOMAIN 5..207
FT /note="Orotidine 5'-phosphate decarboxylase"
FT /evidence="ECO:0000259|SMART:SM00934"
SQ SEQUENCE 220 AA; 23548 MW; 6FAD94411EDC6FD7 CRC64;
MSRPLLQLAL DHSSLEDAQR DVMLLKDSVD IVEAGTILCL NEGLGAVKAL REQCPNKIIV
ADWKVADAGE TLAQQAFGAG ANWMTIICAA PLATVEKGHT MAQRCGGEIQ IELFGNWTLD
DARDWHRIGV RQAIYHRGRD AQASGQQWGE ADLARMKALS DIGLELSITG GITPADLPLF
KDIRVKAFIA GRALAGAANP AQVAGDFHAQ IDAIWGGARA
//
