ID   D3HKS5_LEGLN            Unreviewed;       422 AA.
AC   D3HKS5;
DT   23-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   23-MAR-2010, sequence version 1.
DT   27-MAR-2024, entry version 75.
DE   SubName: Full=Putative GTP cyclohydrolase II {ECO:0000313|EMBL:CBJ13041.1};
GN   OrderedLocusNames=LLO_2615 {ECO:0000313|EMBL:CBJ13041.1};
OS   Legionella longbeachae serogroup 1 (strain NSW150).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC   Legionellaceae; Legionella.
OX   NCBI_TaxID=661367 {ECO:0000313|EMBL:CBJ13041.1, ECO:0000313|Proteomes:UP000001060};
RN   [1] {ECO:0000313|EMBL:CBJ13041.1, ECO:0000313|Proteomes:UP000001060}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NSW150 {ECO:0000313|EMBL:CBJ13041.1,
RC   ECO:0000313|Proteomes:UP000001060};
RX   PubMed=20174605; DOI=10.1371/journal.pgen.1000851;
RA   Cazalet C., Gomez-Valero L., Rusniok C., Lomma M., Dervins-Ravault D.,
RA   Newton H., Sansom F., Jarraud S., Zidane N., Ma L., Bouchier C.,
RA   Etienne J., Hartland E., Buchrieser C.;
RT   "Analysis of the Legionella longbeachae genome and transcriptome uncovers
RT   unique strategies to cause Legionnaires' disease.";
RL   PLoS Genet. 6:E1000851-E1000851(2010).
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DR   EMBL; FN650140; CBJ13041.1; -; Genomic_DNA.
DR   RefSeq; WP_003635535.1; NC_013861.1.
DR   AlphaFoldDB; D3HKS5; -.
DR   STRING; 661367.LLO_2615; -.
DR   KEGG; llo:LLO_2615; -.
DR   eggNOG; COG0807; Bacteria.
DR   HOGENOM; CLU_029639_1_0_6; -.
DR   OrthoDB; 5482269at2; -.
DR   UniPathway; UPA00275; -.
DR   Proteomes; UP000001060; Chromosome.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003935; F:GTP cyclohydrolase II activity; IEA:InterPro.
DR   GO; GO:0009231; P:riboflavin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00641; GTP_cyclohydro2; 1.
DR   Gene3D; 3.40.50.10990; GTP cyclohydrolase II; 1.
DR   InterPro; IPR022163; GTP_CH_N.
DR   InterPro; IPR032677; GTP_cyclohydro_II.
DR   InterPro; IPR000926; RibA.
DR   InterPro; IPR036144; RibA-like_sf.
DR   PANTHER; PTHR47259; -; 1.
DR   PANTHER; PTHR47259:SF2; URACIL-REGULATED PROTEIN 1; 1.
DR   Pfam; PF12471; GTP_CH_N; 1.
DR   Pfam; PF00925; GTP_cyclohydro2; 1.
DR   SUPFAM; SSF142695; RibA-like; 1.
PE   4: Predicted;
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:CBJ13041.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001060}.
FT   DOMAIN          13..201
FT                   /note="GTP cyclohydrolase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12471"
FT   DOMAIN          228..377
FT                   /note="GTP cyclohydrolase II"
FT                   /evidence="ECO:0000259|Pfam:PF00925"
SQ   SEQUENCE   422 AA;  46456 MW;  64F68ED5425B67C0 CRC64;
     MVQEESKKKS KGHIVLSSHP AGHTAAPLKI KWGAQDPKER GPVIASLTNI KNRNAVGTHS
     GSYSVYRALA VAAGVLDPEH VPDLTDTTPP VAIGPHTQWS GTQKIISLDP WGHLVASVFA
     EEIKSGYDIR PTIAVTKAHI NIPELHTAMQ KGRLKPDGKI LKESGDVAVT KAAIEPVWYL
     PGIAERFGVS ESRLRRTLFE QTAGMFPELV TRTDLDVFLP PIGGLTAYFF GDVTTIHDPK
     IELTCRIHDE CNGSDVFGSD ICTCRPYLVH GIELSIESAQ KGGAGLIVYN RKEGRALGEV
     TKFLVYNARK RQKGGDTAAK YFERTECVAG VQDMRFQELM SDVLHWLGIT KIHRFVSMSN
     MKYDALLKSG INISERVTIP DELIPPDAQV EMNAKRAAGY YSPERIVDIN ELAKTKGRDL
     HE
//