ID D3IAN6_9BACT Unreviewed; 836 AA.
AC D3IAN6;
DT 23-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 23-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN ORFNames=HMPREF0669_00490 {ECO:0000313|EMBL:EFC71818.1};
OS Prevotella sp. oral taxon 299 str. F0039.
OG Plasmid unnamed {ECO:0000313|EMBL:EFC71818.1}.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC Prevotella.
OX NCBI_TaxID=575614 {ECO:0000313|EMBL:EFC71818.1, ECO:0000313|Proteomes:UP000015929};
RN [1] {ECO:0000313|EMBL:EFC71818.1, ECO:0000313|Proteomes:UP000015929}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0039 {ECO:0000313|EMBL:EFC71818.1,
RC ECO:0000313|Proteomes:UP000015929};
RC PLASMID=unnamed {ECO:0000313|EMBL:EFC71818.1};
RG The Broad Institute Genome Sequencing Platform;
RA Ward D., Feldgarden M., Earl A., Young S.K., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A., Bochicchio J., Borenstein D., Chapman S.B.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D., Larson L.,
RA Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J.,
RA Yandava C., Izard J., Baranova O.V., Blanton J.M., Tanner A.C.,
RA Dewhirst F.E., Haas B., Nusbaum C., Birren B.;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EFC71818.1, ECO:0000313|Proteomes:UP000015929}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0039 {ECO:0000313|EMBL:EFC71818.1,
RC ECO:0000313|Proteomes:UP000015929};
RC PLASMID=Plasmid {ECO:0000313|Proteomes:UP000015929};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A., Ward D., Feldgarden M., Gevers D., Izard J., Baranova O.V.,
RA Blanton J.M., Tanner A.C., Dewhirst F.E., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Goldberg J., Griggs A., Gujja S.,
RA Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C., Montmayeur A.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Prevotella sp. Oral Taxon 299 strain F0039.";
RL Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004752}.
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DR EMBL; CP003667; EFC71818.1; -; Genomic_DNA.
DR RefSeq; WP_009227666.1; NC_022111.1.
DR AlphaFoldDB; D3IAN6; -.
DR KEGG; pro:HMPREF0669_00490; -.
DR HOGENOM; CLU_006354_2_4_10; -.
DR OrthoDB; 9766909at2; -.
DR Proteomes; UP000015929; Plasmid.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 2.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF11; PENICILLIN-BINDING PROTEIN 1B; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Plasmid {ECO:0000313|EMBL:EFC71818.1};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000015929};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 32..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 89..274
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 448..684
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT REGION 792..836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 792..828
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 836 AA; 95188 MW; D0F166C57C9318D1 CRC64;
MIDKIKKIFS ILLQKIKDFF NWYKKLFVGR AWYIKALSGI ASFFVFIAIY LIAVDVNFLW
LFGKSPGFSE IKKPSTSEAS EIYSADGVLI GKYFNENRTP VKYSDVNPIF WKTLIDTEDE
RFYHHFGIDI PGLFAAAKDA IFRHDARGAS TITQQLAKNM FRVRTNYSTG LLGSIPGIRM
LIMKSKEWII ATKLEMVYDK EDILTMYANT VDFGANSYGI KTASKTYFNT SPKDLTIEQS
AVLVGMLKAT TSYNPITNPE NSLKRRNTVL WRMHQHNDIT KAEYDSLTQI PIKLDVKVEK
NYDGQAQYFR EAVADHLKDW CDENGIDLYS SGLKIYTTID SRMQKYAEDA ARKQMRQVQR
NFNNHWGDND PWIDENGNKI PNFIENIAQK QPYYKYLLAK FPNNPDSISY YLNKPHVVKL
FDYDKGIIEK EISTMDSIRY MVHFMHCAFV AMEPQTGEVK AWVGDIDFNS WKYDKVTAMR
QPGSTFKLFV YTEAMNQGLT PCDKRRDEFI SMKVFDKKKG EEVTWTPSNA NGRFSGDSIP
LKGAFARSIN SVAVRLGQEM GIQRVIETAQ KMGIKSPLDP TPSLALGSSD INLLELTNAY
SVIADDGKHH DPILVTRILD KEGHEVYVAP TSETQVISYK SAFFMQQLLM GGMREPGGTS
QSLWAYVGDY RDTDFGGKTG TSNNHSDAWF MCVSPKLVCG AWVGGEYRSI HFRTGALGQG
SRTALPICGY FLQSVFGDSA FKKYHGQFGK PKDDDITSSM YNCQSYYSSS RRDTTVTDST
NISHEEIILD EDGNIRITPN EGTKHESRPT NEKEQNPRSD KQNKKNKEQV VNFEQL
//
