ID D3NQA9_CAEEL Unreviewed; 304 AA.
AC D3NQA9;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=Carbonic anhydrase {ECO:0000256|RuleBase:RU003956};
DE EC=4.2.1.1 {ECO:0000256|RuleBase:RU003956};
DE AltName: Full=Carbonate dehydratase {ECO:0000256|RuleBase:RU003956};
GN Name=bca-2 {ECO:0000313|EMBL:CBK19484.1,
GN ECO:0000313|WormBase:Y116A8C.28d};
GN ORFNames=CELE_Y116A8C.28 {ECO:0000313|EMBL:CBK19484.1}, Y116A8C.28
GN {ECO:0000313|WormBase:Y116A8C.28d};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CBK19484.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CBK19484.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CBK19484.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Reversible hydration of carbon dioxide.
CC {ECO:0000256|RuleBase:RU003956}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+) + hydrogencarbonate = CO2 + H2O; Xref=Rhea:RHEA:10748,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:17544; EC=4.2.1.1;
CC Evidence={ECO:0000256|RuleBase:RU003956};
CC -!- SIMILARITY: Belongs to the beta-class carbonic anhydrase family.
CC {ECO:0000256|ARBA:ARBA00006217, ECO:0000256|RuleBase:RU003956}.
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DR EMBL; BX284604; CBK19484.1; -; Genomic_DNA.
DR RefSeq; NP_001255922.1; NM_001268993.1.
DR AlphaFoldDB; D3NQA9; -.
DR STRING; 6239.Y116A8C.28d.1; -.
DR PaxDb; 6239-Y116A8C-28d; -.
DR PeptideAtlas; D3NQA9; -.
DR EnsemblMetazoa; Y116A8C.28d.1; Y116A8C.28d.1; WBGene00013805.
DR GeneID; 178484; -.
DR AGR; WB:WBGene00013805; -.
DR WormBase; Y116A8C.28d; CE44607; WBGene00013805; bca-2.
DR eggNOG; KOG1578; Eukaryota.
DR HOGENOM; CLU_053879_5_3_1; -.
DR InParanoid; D3NQA9; -.
DR OMA; MPNVAAW; -.
DR OrthoDB; 5392875at2759; -.
DR PhylomeDB; D3NQA9; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00013805; Expressed in larva and 4 other cell types or tissues.
DR ExpressionAtlas; D3NQA9; baseline and differential.
DR GO; GO:0004089; F:carbonate dehydratase activity; IDA:WormBase.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006730; P:one-carbon metabolic process; IGI:WormBase.
DR Gene3D; 3.40.1050.10; Carbonic anhydrase; 1.
DR InterPro; IPR001765; Carbonic_anhydrase.
DR InterPro; IPR036874; Carbonic_anhydrase_sf.
DR PANTHER; PTHR11002; CARBONIC ANHYDRASE; 1.
DR PANTHER; PTHR11002:SF69; CARBONIC ANHYDRASE; 1.
DR Pfam; PF00484; Pro_CA; 2.
DR SMART; SM00947; Pro_CA; 1.
DR SUPFAM; SSF53056; beta-carbonic anhydrase, cab; 1.
PE 1: Evidence at protein level;
KW Lyase {ECO:0000256|RuleBase:RU003956};
KW Proteomics identification {ECO:0007829|EPD:D3NQA9,
KW ECO:0007829|PeptideAtlas:D3NQA9};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Zinc {ECO:0000256|RuleBase:RU003956}.
FT REGION 79..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..105
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 304 AA; 34931 MW; 867FAF42335FF359 CRC64;
MPGLERILNG VIRFRQTVRK DLVKQFERIR DNPHPTAVFF TCMDSRMLPA RITSSQVGDM
FVVRNSGNMI PHANNYGKIL RRGDTTGKEN REKENWKPRP FLPPETPRRE DLVEKVIYCA
KSPSGYEVSV TTEPAALELA VKRGKINHVI VCGHSDCKAI NTLYNLHKCP KSFDPESPMD
HWLRRHGFNS IRKLEKRLAD KNAGPIEFVS DNPLFSFSAV IDPEDKLNVE DKLSQINTLQ
QLENVASHGF LKEFLVSQTV DLHAMWFDIY TGEMHMFSKP NKQFVLVDES NVEELIDEVE
KHQT
//
