ID D3S897_METSF Unreviewed; 333 AA.
AC D3S897;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=TrkA-N domain protein {ECO:0000313|EMBL:ADC69257.1};
GN OrderedLocusNames=MFS40622_0566 {ECO:0000313|EMBL:ADC69257.1};
OS Methanocaldococcus sp. (strain FS406-22).
OC Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC Methanocaldococcaceae; Methanocaldococcus.
OX NCBI_TaxID=644281 {ECO:0000313|EMBL:ADC69257.1, ECO:0000313|Proteomes:UP000002189};
RN [1] {ECO:0000313|EMBL:ADC69257.1, ECO:0000313|Proteomes:UP000002189}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FS406-22 {ECO:0000313|EMBL:ADC69257.1,
RC ECO:0000313|Proteomes:UP000002189};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., Teshima H., Detter J.C., Han C., Tapia R., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Mikhailova N., Sieprawska-Lupa M., Leigh J.,
RA Whitman W.B., Woyke T.;
RT "Complete sequence of chromosome of Methanocaldococcus sp. FS406-22.";
RL Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP001901; ADC69257.1; -; Genomic_DNA.
DR RefSeq; WP_012980167.1; NC_013887.1.
DR AlphaFoldDB; D3S897; -.
DR STRING; 644281.MFS40622_0566; -.
DR GeneID; 8804407; -.
DR KEGG; mfs:MFS40622_0566; -.
DR eggNOG; arCOG01958; Archaea.
DR HOGENOM; CLU_050982_0_1_2; -.
DR OrthoDB; 43518at2157; -.
DR Proteomes; UP000002189; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005267; F:potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.70.1450; Regulator of K+ conductance, C-terminal domain; 1.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR013099; K_chnl_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR006037; RCK_C.
DR InterPro; IPR036721; RCK_C_sf.
DR InterPro; IPR003148; RCK_N.
DR PANTHER; PTHR43833:SF9; POTASSIUM CHANNEL PROTEIN 2-RELATED; 1.
DR PANTHER; PTHR43833; POTASSIUM CHANNEL PROTEIN 2-RELATED-RELATED; 1.
DR Pfam; PF07885; Ion_trans_2; 1.
DR Pfam; PF02080; TrkA_C; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR PRINTS; PR01333; 2POREKCHANEL.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF116726; TrkA C-terminal domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS51202; RCK_C; 1.
DR PROSITE; PS51201; RCK_N; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 33..52
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 64..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 109..232
FT /note="RCK N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51201"
FT DOMAIN 246..331
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
SQ SEQUENCE 333 AA; 36997 MW; AB6D5B6A50D2C33E CRC64;
METIKKIELG VIVIILLILI EAIILMTVEG WDFFTAFYTA VVTISTVGYG DYTPKTFIGK
LSVIIYIFAG VGAVAYTMGN IASFFIEGHF KKYFRLRKMM DKIKKLNNHY IICGYGRLGK
VIAEEFKKSN IPFVIIDSDE KILEEAIEKD PNLVCIVGDA TSDDILKKAK IEKAKGLISV
VSSDAENVFI TLSAKKLNPN IYIVAKAEKP STLDKLIKAG ADRAVCPYIV GGMEIARIAI
NPDIVEFIHS LVATEEDMEV RRYIVKNKEL DNKLLKDSGI REKTGATILA IKKGDKTITS
PPPDTVINIG DTIYAFGTKE QLEKLKRYVE GII
//
