ID D3T143_NATMM Unreviewed; 392 AA.
AC D3T143;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Creatinase {ECO:0000313|EMBL:ELY32730.1};
DE SubName: Full=Peptidase M24 family protein (Homolog to ectoine hydrolase) {ECO:0000313|EMBL:ADD07302.1};
GN OrderedLocusNames=Nmag_3760 {ECO:0000313|EMBL:ADD07302.1};
GN ORFNames=C500_03499 {ECO:0000313|EMBL:ELY32730.1};
OS Natrialba magadii (strain ATCC 43099 / DSM 3394 / CCM 3739 / CIP 104546 /
OS IAM 13178 / JCM 8861 / NBRC 102185 / NCIMB 2190 / MS3) (Natronobacterium
OS magadii).
OG Plasmid pNMAG01 {ECO:0000313|EMBL:ADD07302.1,
OG ECO:0000313|Proteomes:UP000001879}.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC Natrialbaceae; Natrialba.
OX NCBI_TaxID=547559 {ECO:0000313|EMBL:ADD07302.1, ECO:0000313|Proteomes:UP000001879};
RN [1] {ECO:0000313|Proteomes:UP000001879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43099 / DSM 3394 / CCM 3739 / CIP 104546 / IAM 13178 / JCM
RC 8861 / NBRC 102185 / NCIMB 2190 / MS3
RC {ECO:0000313|Proteomes:UP000001879};
RC PLASMID=pNMAG01 {ECO:0000313|Proteomes:UP000001879};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., Davenport K., Saunders E., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Kyrpides N., Mikhailova N., De Castro R.E.,
RA Maupin-Furlow J.A., Woyke T.;
RT "Complete sequence of plasmid 1 of Natrialba magadii ATCC 43099.";
RL Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADD07302.1, ECO:0000313|Proteomes:UP000001879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43099 {ECO:0000313|EMBL:ADD07302.1}, and ATCC 43099 / DSM
RC 3394 / CCM 3739 / CIP 104546 / IAM 13178 / JCM 8861 / NBRC 102185 /
RC NCIMB 2190 / MS3 {ECO:0000313|Proteomes:UP000001879};
RX PubMed=22559199; DOI=10.1186/1471-2164-13-165;
RA Siddaramappa S., Challacombe J.F., Decastro R.E., Pfeiffer F., Sastre D.E.,
RA Gimenez M.I., Paggi R.A., Detter J.C., Davenport K.W., Goodwin L.A.,
RA Kyrpides N., Tapia R., Pitluck S., Lucas S., Woyke T., Maupin-Furlow J.A.;
RT "A comparative genomics perspective on the genetic content of the
RT alkaliphilic haloarchaeon Natrialba magadii ATCC 43099T.";
RL BMC Genomics 13:165-165(2012).
RN [3] {ECO:0000313|EMBL:ELY32730.1, ECO:0000313|Proteomes:UP000011543}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43099 / DSM 3394 / CCM 3739 / CIP 104546 / IAM 13178 / JCM
RC 8861 / NBRC 102185 / NCIMB 2190 / MS3
RC {ECO:0000313|Proteomes:UP000011543}, and MS-3
RC {ECO:0000313|EMBL:ELY32730.1};
RX PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT strategies for static and dynamic osmo-response.";
RL PLoS Genet. 10:E1004784-E1004784(2014).
RN [4] {ECO:0000313|EMBL:ADD07302.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 43099 {ECO:0000313|EMBL:ADD07302.1};
RC PLASMID=pNMAG01 {ECO:0000313|EMBL:ADD07302.1};
RA Pfeiffer F.;
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP001933; ADD07302.1; -; Genomic_DNA.
DR EMBL; AOHS01000012; ELY32730.1; -; Genomic_DNA.
DR RefSeq; WP_004214229.1; NZ_AOHS01000012.1.
DR AlphaFoldDB; D3T143; -.
DR GeneID; 8826630; -.
DR KEGG; nmg:Nmag_3760; -.
DR PATRIC; fig|547559.17.peg.667; -.
DR HOGENOM; CLU_017266_3_1_2; -.
DR OrthoDB; 1346at2157; -.
DR Proteomes; UP000001879; Plasmid pNMAG01.
DR Proteomes; UP000011543; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd01066; APP_MetAP; 1.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 1.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000587; Creatinase_N.
DR InterPro; IPR000994; Pept_M24.
DR PANTHER; PTHR46112; AMINOPEPTIDASE; 1.
DR PANTHER; PTHR46112:SF2; XAA-PRO AMINOPEPTIDASE P-RELATED; 1.
DR Pfam; PF01321; Creatinase_N; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:ADD07302.1};
KW Plasmid {ECO:0000313|EMBL:ADD07302.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001879}.
FT DOMAIN 14..159
FT /note="Creatinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01321"
FT DOMAIN 167..375
FT /note="Peptidase M24"
FT /evidence="ECO:0000259|Pfam:PF00557"
SQ SEQUENCE 392 AA; 43795 MW; A8B747109AE67C42 CRC64;
MSRDIFDDAE YERRLDRTKT RLREENLDAI VVTDPANMNY LTGYDGWSFY VHQAVVVTTD
RDEPVWVGRG MDADGARATT SLSEESIRAY SDDHVHSPYD LHPMDYVAGV LEELDVAEGR
IGLEMDAAYF TAKSYTRLQQ NLPDADFEDT TLLVGWVRVK KSDQELEYMR EAAQISETAM
QAGLDAIEAG VPEYEAAAAI YDALISGTDE FGGDYPSIVP LMPSGDHTGT PHLTWTDRPF
EEGDPVIIEL SGCRHRYHSP LARTTFVGEP PAELERTAEI VNEGIQAALD VAEPGVTCED
VEKAWRETIA KYDIEKEDRI GYSVGLGYPP DWGEHTASIR PGDETVLEEN MTFHMIPGIW
TEDIGMETSE TFRVTSNGVE TLADFPRKLF TA
//
