ID   D3T4G2_THEIA            Unreviewed;       612 AA.
AC   D3T4G2;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   27-MAR-2024, entry version 56.
DE   SubName: Full=UBA/THIF-type NAD/FAD binding protein {ECO:0000313|EMBL:ADD03114.1};
GN   OrderedLocusNames=Thit_1872 {ECO:0000313|EMBL:ADD03114.1};
OS   Thermoanaerobacter italicus (strain DSM 9252 / Ab9).
OC   Bacteria; Bacillota; Clostridia; Thermoanaerobacterales;
OC   Thermoanaerobacteraceae; Thermoanaerobacter.
OX   NCBI_TaxID=580331 {ECO:0000313|EMBL:ADD03114.1, ECO:0000313|Proteomes:UP000001552};
RN   [1] {ECO:0000313|EMBL:ADD03114.1, ECO:0000313|Proteomes:UP000001552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 9252 / JCM 16815 / Ab9 {ECO:0000313|Proteomes:UP000001552};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA   Kyrpides N., Mikhailova N., Hemme C.L., Woyke T.;
RT   "Complete sequence of Thermoanaerobacter italicus Ab9.";
RL   Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP001936; ADD03114.1; -; Genomic_DNA.
DR   RefSeq; WP_012995825.1; NC_013921.1.
DR   AlphaFoldDB; D3T4G2; -.
DR   KEGG; tit:Thit_1872; -.
DR   eggNOG; COG0476; Bacteria.
DR   HOGENOM; CLU_019556_0_0_9; -.
DR   OrthoDB; 4088010at2; -.
DR   Proteomes; UP000001552; Chromosome.
DR   GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR   CDD; cd01483; E1_enzyme_family; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR032701; Prok-E2_B_dom.
DR   InterPro; IPR045886; ThiF/MoeB/HesA.
DR   InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR   InterPro; IPR035985; Ubiquitin-activating_enz.
DR   PANTHER; PTHR43267; TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE; 1.
DR   PANTHER; PTHR43267:SF1; TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE; 1.
DR   Pfam; PF14461; Prok-E2_B; 1.
DR   Pfam; PF00899; ThiF; 1.
DR   SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 1.
PE   4: Predicted;
FT   DOMAIN          38..144
FT                   /note="Prokaryotic E2 family B"
FT                   /evidence="ECO:0000259|Pfam:PF14461"
FT   DOMAIN          327..473
FT                   /note="THIF-type NAD/FAD binding fold"
FT                   /evidence="ECO:0000259|Pfam:PF00899"
SQ   SEQUENCE   612 AA;  69836 MW;  501214F69F80FCCB CRC64;
     MLNVIEEYIR KSLPYYNEVR VLDRSEYPKY GNYNFSLVME GKVLLEGQSV TIQIALDDRF
     PLHKPLFFLK PYDALGFIPH VDINGFICYI RDEGIVIDTD NPLAIIEESF ERVIKTLTDG
     KSGANYKDIQ EEFEAYWGNL KDVSFIESNV ELTNNVKVVK AAAFENYPRW FVGDSVNEII
     NYCYKYIGRT RMGKPTFTDA LYIPLRDGTI LNPPYYGDFW TVKQFRNLIY KNITSSNKRI
     LEKIVKRKIR YDEVLIVLVS IPLSNGNKSL IGVKYSEFIP IEMNKNRLKK ELSHPLYRTD
     ANCKFVPLSV IRHDKAYIIP RGGGNSLLKD KKVALIGCGS VGGYIAVELA KAGIQKITLI
     DQDYLMQENV YRHVLGTDSL LMEKYKNGEK VEVLSNPKII GLKNEIERKL PYTNVDVLPE
     YIDKIENIIS NNTIDFKQFD LVIVAIGNPT IELYLNEFFH KNENMPPVIF TWVEAYGIGG
     HALLTNNNGK SGCLKCLYTD PFDEKAPLYN RASFAAAGQN FTKQVSGCSS VYIPYSSLDS
     MQTAILATRL AIDTLSGKEK DNPILSWKGN ADIFIENGFK LSDRYSIPYE QLYDSRYLYK
     NKSCKICGHL KG
//