ID D3TRT0_GLOMM Unreviewed; 314 AA.
AC D3TRT0;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 13-SEP-2023, entry version 48.
DE RecName: Full=Cyclin-H {ECO:0000256|ARBA:ARBA00019496};
OS Glossina morsitans morsitans (Savannah tsetse fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=37546 {ECO:0000313|EMBL:ADD20408.1};
RN [1] {ECO:0000313|EMBL:ADD20408.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Salivary gland {ECO:0000313|EMBL:ADD20408.1};
RX PubMed=20353571; DOI=10.1186/1471-2164-11-213;
RA Alves-Silva J., Ribeiro J.M., Van Den Abbeele J., Attardo G., Hao Z.,
RA Haines L.R., Soares M.B., Berriman M., Aksoy S., Lehane M.J.;
RT "An insight into the sialome of Glossina morsitans morsitans.";
RL BMC Genomics 11:213-213(2010).
RN [2] {ECO:0000313|EMBL:ADD20408.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Salivary gland {ECO:0000313|EMBL:ADD20408.1};
RG International Glossina Genome Initiative;
RA da Silva J., Ribeiro J.M.C., Abbeele J.V., Attardo G., Hao Z., Haines L.R.,
RA Soares M.B., Berriman M., Aksoy S., Lehane M.J.;
RL Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Regulates CDK7, the catalytic subunit of the CDK-activating
CC kinase (CAK) enzymatic complex. CAK activates the cyclin-associated
CC kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK
CC complexed to the core-TFIIH basal transcription factor activates RNA
CC polymerase II by serine phosphorylation of the repetitive C-terminal
CC domain (CTD) of its large subunit (POLR2A), allowing its escape from
CC the promoter and elongation of the transcripts. Involved in cell cycle
CC control and in RNA transcription by RNA polymerase II. Its expression
CC and activity are constant throughout the cell cycle.
CC {ECO:0000256|ARBA:ARBA00025343}.
CC -!- SUBUNIT: Associates primarily with CDK7 and MAT1 to form the CAK
CC complex. CAK can further associate with the core-TFIIH to form the
CC TFIIH basal transcription factor. {ECO:0000256|ARBA:ARBA00026042}.
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin C subfamily.
CC {ECO:0000256|ARBA:ARBA00008638}.
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DR EMBL; EZ424132; ADD20408.1; -; mRNA.
DR AlphaFoldDB; D3TRT0; -.
DR GO; GO:0070985; C:transcription factor TFIIK complex; IEA:InterPro.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:InterPro.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd20524; CYCLIN_CCNH_rpt1; 1.
DR CDD; cd20525; CYCLIN_CCNH_rpt2; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR043198; Cyclin/Ssn8.
DR InterPro; IPR031658; Cyclin_C_2.
DR InterPro; IPR006671; Cyclin_N.
DR InterPro; IPR027081; CyclinH/Ccl1.
DR NCBIfam; TIGR00569; ccl1; 1.
DR PANTHER; PTHR10026; CYCLIN; 1.
DR PANTHER; PTHR10026:SF8; CYCLIN-H; 1.
DR Pfam; PF16899; Cyclin_C_2; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
PE 2: Evidence at transcript level;
KW Cyclin {ECO:0000256|RuleBase:RU000383};
KW Kinase {ECO:0000313|EMBL:ADD20408.1};
KW Transferase {ECO:0000313|EMBL:ADD20408.1}.
FT DOMAIN 62..149
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
SQ SEQUENCE 314 AA; 37041 MW; 257E0F704718495D CRC64;
MFPLSSQKKY WTFNNEQHLN ELRKKQNEKF QETHGEAEAE DNKLDYFLDS SEERLLLKQY
EIYLNDFCRR FEPIMPKCVV GTSFHYFKRF YLHNSPMDFH PKEILATCVY LACKVEEFNV
SIGQFVNNIK GDRNKAMDII LSSEMLLMQH LNYYLTVHNP YRPIEGFLID IKTRSSLTNA
ERLRQHIDDF IEKSFFTDAC LLYAPSQIAL AAVLHAASRE QENLDSYVTD ILFNGAREKL
PLLVEAIRKI RLMVKQYEIP ARDKVKTIEK KLEKCRNQEN NPDSEIYKER MRKMFCDDDL
EIDLQANSAA DMSV
//
