ID D3UD30_SUSCL Unreviewed; 236 AA.
AC D3UD30;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 24-JAN-2024, entry version 63.
DE RecName: Full=Sex-determining region Y protein {ECO:0000256|ARBA:ARBA00019052, ECO:0000256|PIRNR:PIRNR037653};
GN Name=SRY {ECO:0000313|EMBL:CAX51908.1};
OS Sus celebensis (Celebes wild boar) (Sulawesi warty pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=273789 {ECO:0000313|EMBL:CAX51908.1};
RN [1] {ECO:0000313|EMBL:CAX51908.1}
RP NUCLEOTIDE SEQUENCE.
RA Cliffe K.M., Day A.E., Bagga M., Siggens K., Quilter C.R., Lowden S.,
RA Finlayson H.A., Palgrave C.J., Li N., Huang L., Blott S.C., Sargent C.A.;
RT "Analysis of the non-recombining Y chromosome defines polymorphisms in
RT domestic pig breeds: ancestral bases identified by comparative
RT sequencing.";
RL Anim. Genet. 41:619-629(2010).
CC -!- FUNCTION: Transcriptional regulator that controls a genetic switch in
CC male development. It is necessary and sufficient for initiating male
CC sex determination by directing the development of supporting cell
CC precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells.
CC Involved in different aspects of gene regulation including promoter
CC activation or repression. Binds to the DNA consensus sequence 5'-
CC [AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation
CC in the minor groove and promotes DNA bending. Also involved in pre-mRNA
CC splicing (By similarity). In male adult brain involved in the
CC maintenance of motor functions of dopaminergic neurons.
CC {ECO:0000256|ARBA:ARBA00025418}.
CC -!- SUBUNIT: Interacts with CALM, EP300, HDAC3, KPNB1, ZNF208 isoform KRAB-
CC O, PARP1, SLC9A3R2 and WT1. The interaction with EP300 modulates its
CC DNA-binding activity. The interaction with KPNB1 is sensitive to
CC dissociation by Ran in the GTP-bound form. Interaction with PARP1
CC impaired its DNA-binding activity. {ECO:0000256|ARBA:ARBA00024048}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
CC -!- SIMILARITY: Belongs to the SRY family. {ECO:0000256|ARBA:ARBA00005998,
CC ECO:0000256|PIRNR:PIRNR037653}.
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DR EMBL; FN186125; CAX51908.1; -; Genomic_DNA.
DR AlphaFoldDB; D3UD30; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0030238; P:male sex determination; IEA:InterPro.
DR GO; GO:0007548; P:sex differentiation; IEA:UniProtKB-KW.
DR CDD; cd22034; HMG-box_SoxA_SRY; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR017253; SRY.
DR PANTHER; PTHR10270:SF199; SEX-DETERMINING REGION Y PROTEIN; 1.
DR PANTHER; PTHR10270; SOX TRANSCRIPTION FACTOR; 1.
DR Pfam; PF00505; HMG_box; 1.
DR PIRSF; PIRSF037653; SRY; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|PIRNR:PIRNR037653};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782,
KW ECO:0000256|PIRNR:PIRNR037653};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037653};
KW Nucleus {ECO:0000256|PIRNR:PIRNR037653, ECO:0000256|PROSITE-
KW ProRule:PRU00267};
KW Sexual differentiation {ECO:0000256|ARBA:ARBA00022928,
KW ECO:0000256|PIRNR:PIRNR037653};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR037653};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|PIRNR:PIRNR037653}.
FT DOMAIN 62..130
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 62..130
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 32..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 236 AA; 27214 MW; 77C7E67F6EFE9393 CRC64;
MVQSYASAMF RVLKADDYSP AAQQQNILAL GKGSSLFPTD NHSSNDGRET RGNGRESGQD
RVKRPMNAFI VWSRDQRRKV ALENPQMQNS EISKWLGCKW KMLTEAEKRP FFEEAQRLQA
VHRDKYPGYK YRPRRKGERA QNLLPAEAAV LCSQVRVEER MYPFTYTVAK AKCSGTESQL
RHSQPMNITS SLLQQEDRCN WTGLCHSRVT STRQIRADLP FHRGLQPGLS HIYFPY
//
