ID D3VEI7_XENNA Unreviewed; 2242 AA.
AC D3VEI7;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Non-ribosomal peptide synthetase {ECO:0000313|EMBL:CBJ90099.1};
GN OrderedLocusNames=XNC1_2039 {ECO:0000313|EMBL:CBJ90099.1};
OS Xenorhabdus nematophila (strain ATCC 19061 / DSM 3370 / CCUG 14189 / LMG
OS 1036 / NCIMB 9965 / AN6).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Morganellaceae; Xenorhabdus.
OX NCBI_TaxID=406817 {ECO:0000313|EMBL:CBJ90099.1, ECO:0000313|Proteomes:UP000008075};
RN [1] {ECO:0000313|EMBL:CBJ90099.1, ECO:0000313|Proteomes:UP000008075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19061 / DSM 3370 / CCUG 14189 / LMG 1036 / NCIMB 9965 /
RC AN6 {ECO:0000313|Proteomes:UP000008075};
RX PubMed=22125637; DOI=10.1371/journal.pone.0027909;
RA Chaston J.M., Suen G., Tucker S.L., Andersen A.W., Bhasin A., Bode E.,
RA Bode H.B., Brachmann A.O., Cowles C.E., Cowles K.N., Darby C., de Leon L.,
RA Drace K., Du Z., Givaudan A., Herbert Tran E.E., Jewell K.A., Knack J.J.,
RA Krasomil-Osterfeld K.C., Kukor R., Lanois A., Latreille P.,
RA Leimgruber N.K., Lipke C.M., Liu R., Lu X., Martens E.C., Marri P.R.,
RA Medigue C., Menard M.L., Miller N.M., Morales-Soto N., Norton S.,
RA Ogier J.C., Orchard S.S., Park D., Park Y., Qurollo B.A., Sugar D.R.,
RA Richards G.R., Rouy Z., Slominski B., Slominski K., Snyder H., Tjaden B.C.,
RA van der Hoeven R., Welch R.D., Wheeler C., Xiang B., Barbazuk B.,
RA Gaudriault S., Goodner B., Slater S.C., Forst S., Goldman B.S.,
RA Goodrich-Blair H.;
RT "The entomopathogenic bacterial endosymbionts xenorhabdus and photorhabdus:
RT convergent lifestyles from divergent genomes.";
RL PLoS ONE 6:E27909-E27909(2011).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; FN667742; CBJ90099.1; -; Genomic_DNA.
DR STRING; 406817.XNC1_2039; -.
DR KEGG; xne:XNC1_2039; -.
DR eggNOG; COG1020; Bacteria.
DR HOGENOM; CLU_000022_11_0_6; -.
DR Proteomes; UP000008075; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR CDD; cd12117; A_NRPS_Srf_like; 2.
DR CDD; cd19544; E-C_NRPS; 1.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF00550; PP-binding; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008075}.
FT DOMAIN 1034..1108
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2133..2208
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2242 AA; 248122 MW; 6C93553EC5B8F91D CRC64;
MNLEELKRAV LEKRIEEQLK SRGSQQQSLI KKADRHRPLP LSFAQQRLWF LCQLDPAASL
AYHLPVILRL SGQLNRQALT MSLNNLIARH ESLRTRFVLI EEQPCQHIEP ADIGFALSCH
DLQQLDPALH DERVTEIADL EAQAPFDLTQ GPLIRGQLLQ LTNEQHVLLL TLHHIITDGW
SVGVLVREMG DYYRAVLDND DASLPELPVQ YADYAVWQQD QLQGNPQQGT RLTKQRDFWC
NRLKDAPNLL ELPTDRPRPA VQSYVGGHVS FRLNASLLAS LKALGQRHNA TLFMTMMTAW
SVVLARLSGQ DDLVIGTPVA NRPHHDLEGL IGFFVNTLAL RIRFNRDLNV AELLAQVREQ
ALTAYAHQDL PFEQVVEALQ PERSLSYSPI FQVMLAFNNT PSQTLTLPGL QLTPVEQKRR
GAHFDLALSL SETEVGLAGD LEYAADLFDS ATVERMIGYL IHVLTAMVAD EKQPVATLPM
LYDSERQQLL VEFNATQTDF PQDALIHQLF EAQAERNPDA IAIAFEEQTL SYGELNRRAN
RLAHYLIAQG VRPDSRVAIC LERSPETIVG LLGILKAGGA YVPLDPAYPT ERLAYMLKDA
APVVLLTETA QFDRLSGTLP AMMSVVMLDE QNTPPATQLL ATQSDHNPTA QASGLTSRHL
AYVIYTSGST GQPKGVMVEH HNVNRLIINN GYADITAEDC VAHCANIAFD ASTWEIWSAL
LNGGRLHIVS QSVLLDPAQF RDSLIKGKVT ALWLTAGLFN EYLDTLKPLL GQLRYLLIGG
DVLDPNKIQQ VQSAVLKPTY LLNGYGPTET TTFAATYTIP LSIDVTRSIP IGRPISNTQI
YILDSYGQPV PLGVTGEIYI AGFGVARGYL NHAELTAERF LTDPFASPFV SNLNARMYKT
GDLGRWLPDG NIEFRGRNDF QVKLRGFRIE LGEIETRLRQ CPGVQEAVVL VREDLLDESS
TVQKHLVAYL LPQTGVKLVP SELRQQLTQH LADYMLPGAF VILESFPLTP NGKLDRQALP
APDLSAVISR DYAVPQGEAE IALAEIWQNL LKLQQVSRHD HFFELGGHSL MIVSLMEKLR
HIGWQLDVRS VFATPVLTDM AQTLRRDTHA FIVPPNLVPE GCTAITPDML PLVALSQTEI
DDIVDLIPAG ASQVQDIYPL SPLQEGILFH YLMQDQGDTY LLQSLLAFDN RHRLDRFLEA
LQQVIDRHDI LRTAVYWQGL KQPVQVVWRQ APLAINIFAP ATESDISSQP ILAQLQAHTD
PRRHRINLNQ APLFAADIAH DSAQNEWLLA LRFHHLVSDH MTLELILAEI ALILQGNAEK
LPNALPYRNF IAQTLHTPTE EHEAYFRAQL ADIDEPTAPF GVLSIANHDA PIAEDRLLLN
PALAEAIRIH AKRLKISPSV LFHVAWAQVL AQTSGRDDVV FGSVLLGRLQ GGAGADQILG
MFINTLPVRI SLAGQPVQAV VQSTYHNLMT LLEHEQASLA LAQGCSGVAQ SMPLFSSLLN
YRHSRPAETN SADAVWSGIR AITTKEQTNY PITLSVDDFG TDFYLTAQTV ASIDPTRVIH
YLMTAVKGLV DALAHHPQQS ILDIPVLPET EQKRVLIDFN ATQADFPQHA LIHQRVETQT
ANHPDAIAAV FEDKKLSYGE LNRRANQLAH YLIALGVRPD DRVAICAERS LETVVGLLGI
LKAGGAYVPL DPTCPSERLA HMLEDAAPVV LLTQAVHADQ LSGLLPSDCT LPVVVIDNQE
PCLAEQPNHN PDAQALGLTS RHLAYVLYTS GSTGRPKGVM VEHRNVNNLV IGNSYVAIGA
DDCVAHCANI AFDASTWEIW SALLNGGHLH IVSQSVLLDP IRFRDSLLQG KVTALLLITG
LFNEYLETLI PLFGQLRYLL IGGDALDPRK IQRLQLAESQ PAHLINAYGP TEITVAAATY
AINSPVKVNS PIPIGRPISN SRIYILDTRG QPTPIGVTGE IHIAGAGVSR GYLNHPDITV
ERFLPDPFSS APDMRMFKTG DLGRWLPDGN IEYLARNDFQ VKLRGFRIEP GEIEARLKQC
HGIHDAIVIV REDMSDENVT GQKRLVAYLL PQEGAELIPA ELRQQLALHL ADYMLPSAFV
TLDAFPLTPN GKLDRQALPA PDVSSVVVHS YEAPNSDEEI MLAQIWQDLL GLARVGRHDH
FFELGGHSLM LVQLATRIQD QFLVDIPISS LFLFPQLAAQ ADIILTAQMD AIGENDMESL
QNALDSMSTE ELMVILGGDN NK
//
