ID D3W7V6_9HEPC Unreviewed; 664 AA.
AC D3W7V6;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Polyprotein {ECO:0000313|EMBL:ADC54603.1};
DE Flags: Fragment;
OS hepatitis C virus genotype 1a.
OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes;
OC Amarillovirales; Flaviviridae; Hepacivirus; Hepacivirus hominis.
OX NCBI_TaxID=2847144 {ECO:0000313|EMBL:ADC54603.1};
RN [1] {ECO:0000313|EMBL:ADC54603.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=1238 {ECO:0000313|EMBL:ADC54603.1};
RX PubMed=19918975; DOI=10.1002/hep.23319;
RA Fuller M.J., Shoukry N.H., Gushima T., Bowen D.G., Callendret B.,
RA Campbell K.J., Hasselschwert D.L., Hughes A.L., Walker C.M.;
RT "Selection-driven immune escape is not a significant factor in the failure
RT of CD4 T cell responses in persistent hepatitis C virus infection.";
RL Hepatology 51:378-387(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR EMBL; GQ848815; ADC54603.1; -; Genomic_RNA.
DR MEROPS; C18.001; -.
DR euHCVdb; GQ848815; -.
DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0044423; C:virion component; IEA:UniProtKB-KW.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR GO; GO:0019087; P:transformation of host cell by virus; IEA:InterPro.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR CDD; cd20903; HCV_p7; 1.
DR Gene3D; 2.40.10.120; -; 1.
DR Gene3D; 6.10.250.1610; -; 1.
DR Gene3D; 6.10.250.1750; -; 1.
DR Gene3D; 2.30.30.710; Hepatitis C virus non-structural protein NS2, C-terminal domain; 1.
DR Gene3D; 1.20.1280.150; Hepatitis C virus non-structural protein NS2, N-terminal domain; 1.
DR InterPro; IPR002531; HCV_NS1.
DR InterPro; IPR002518; HCV_NS2.
DR InterPro; IPR042205; HCV_NS2_C.
DR InterPro; IPR042209; HCV_NS2_N.
DR InterPro; IPR004109; HepC_NS3_protease.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR Pfam; PF01560; HCV_NS1; 1.
DR Pfam; PF01538; HCV_NS2; 1.
DR Pfam; PF02907; Peptidase_S29; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS51693; HCV_NS2_PRO; 1.
DR PROSITE; PS51822; HV_PV_NS3_PRO; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW Virion {ECO:0000256|ARBA:ARBA00022844};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT TRANSMEM 150..172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 184..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 215..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 246..264
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 270..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 331..458
FT /note="Peptidase C18"
FT /evidence="ECO:0000259|PROSITE:PS51693"
FT DOMAIN 459..640
FT /note="Peptidase S29"
FT /evidence="ECO:0000259|PROSITE:PS51822"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADC54603.1"
FT NON_TER 664
FT /evidence="ECO:0000313|EMBL:ADC54603.1"
SQ SEQUENCE 664 AA; 72905 MW; 38E61DF670FB3D48 CRC64;
CVIGGAGNNT LHCPTDCFRK HPDATYSRCG SGPWLTPRCL VNYPYRLWHY PCTINYTIFK
IRMYVGGVEH RLEAACNWTR GERCDLEDRD RSELSPLLLT TTQWQVLPCS FTTLPALPTG
LIHLHQNIVD VQYLYGVGSS IASWAIKWDY VVLLFLLLAD ARVCSCLWMM LLISQAEAAL
ENLVVLNAAS LAGTHSLASF LVFFCLAWYL KGKWVPGAVY TFYGMWPLLL LLLALPQRAY
ALDTEAAASC GGVVLVGLMA LTLSPYYKHY ISWCLWWLQY FLTRVEALLH VWIPPLNVRG
GRDAVILLMC AVHPTLVFDI TKLLLAVFGP LWILQANLLK VPYFVRVQGL LRFCALARKM
IGGHYVQMVI IKLGALTGTY VYNHLTPLRD WAHNGLRDLA VAVEPVVFSQ METKLITGGA
DTAACGDIID GLPVSARRGR EILLGPADGM VSKGWRLLAP ITAYAQQTRG LLGCIITSLT
GRDKNQVEGE VQIVSTAAQT FLATCINGVC WTVYHGAGTR TIASPKGPVI QMYTNVDQDL
VGWPASQGSR SLTPCTCGSS DLYLVTRHAD VIPVRRRGDS RGSLLSPRPI SYLKGSSGGP
LLCPAGHAVG IFRAAVCTRG VAKAVDFIPV ENLETTMRSP VFTDNSSPPV VPQSFQVAHL
HAPT
//
