ID D3YTR3_MOUSE Unreviewed; 718 AA.
AC D3YTR3; E9PUA0;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 2.
DT 27-MAR-2024, entry version 96.
DE SubName: Full=Mex3 RNA binding family member D {ECO:0000313|Ensembl:ENSMUSP00000100987.3};
GN Name=Mex3d {ECO:0000313|Ensembl:ENSMUSP00000100987.3,
GN ECO:0000313|MGI:MGI:2681847};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000100987.3, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000100987.3, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000100987.3,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000100987.3}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000100987.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; NP_941017.2; NM_198615.2.
DR AlphaFoldDB; D3YTR3; -.
DR SMR; D3YTR3; -.
DR SwissPalm; D3YTR3; -.
DR EPD; D3YTR3; -.
DR PaxDb; 10090-ENSMUSP00000057962; -.
DR PeptideAtlas; D3YTR3; -.
DR ProteomicsDB; 324298; -.
DR Antibodypedia; 22752; 61 antibodies from 21 providers.
DR DNASU; 237400; -.
DR Ensembl; ENSMUST00000105350.3; ENSMUSP00000100987.3; ENSMUSG00000048696.12.
DR GeneID; 237400; -.
DR KEGG; mmu:237400; -.
DR UCSC; uc007gcz.1; mouse.
DR AGR; MGI:2681847; -.
DR CTD; 399664; -.
DR MGI; MGI:2681847; Mex3d.
DR VEuPathDB; HostDB:ENSMUSG00000048696; -.
DR GeneTree; ENSGT00940000162613; -.
DR HOGENOM; CLU_025598_2_1_1; -.
DR OMA; PFERSGN; -.
DR OrthoDB; 50983at2759; -.
DR ChiTaRS; Mex3d; mouse.
DR Proteomes; UP000000589; Chromosome 10.
DR Bgee; ENSMUSG00000048696; Expressed in seminiferous tubule of testis and 213 other cell types or tissues.
DR ExpressionAtlas; D3YTR3; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035925; F:mRNA 3'-UTR AU-rich region binding; IEA:Ensembl.
DR CDD; cd22423; KH-I_MEX3_rpt1; 1.
DR CDD; cd22424; KH-I_MEX3_rpt2; 1.
DR CDD; cd16518; RING-HC_MEX3; 1.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR047228; KH-I_MEX3_rpt1.
DR InterPro; IPR047226; KH-I_MEX3_rpt2.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR047227; MEX3.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR23285; RING FINGER AND KH DOMAIN CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR23285:SF3; RNA-BINDING PROTEIN MEX3D; 1.
DR Pfam; PF00013; KH_1; 2.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR SMART; SM00322; KH; 2.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50084; KH_TYPE_1; 2.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 1: Evidence at protein level;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Proteomics identification {ECO:0007829|EPD:D3YTR3,
KW ECO:0007829|MaxQB:D3YTR3};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00117}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 667..707
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 61..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 432..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 546..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 594..658
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..566
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 606..656
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 718 AA; 72313 MW; CEC88BAD3AC783B4 CRC64;
MPGSTGQPDA GGAGTGTTAG DPGHPHPALA GAEDAAPRPP PEPDDAAAAL RLALDQLSAL
GLGGARPGDE GMATRSADGA TECGEDEPAP PDELEVAVAP PVTGAPSMGV GPSMALAPSV
TCAPSMALAP SVTSAPSMAL APSVTCAPCM AVAPSVTVAP SMALTPSVTL APTMAVASSV
APGGLPLLDP DVSPRPSPPD VFASFAPHPA ALGPSTLLAE QLNVIGSRKK SVNMTECVPV
PSSEHVAEIV GRQGCKIKAL RAKTNTYIKT PVRGEEPVFI VTGRKEDVEM AKREILSAAE
HFSLIRATRS KAGGLSGATP GPPNLPGQTT IQVRVPYRVV GLVVGPKGAT IKRIQQRTHT
YIVTPGRDKE PVFAVTGMPE NVDRAREEIE AHITLRTGAF TDSGPDSDFH ANGTDVCLDL
LGAAASLWAK APHPGRRPPA ATGGLRGDNA LGAASTPEPF YVGSRGGPPL PDPSPSSPYG
GSGNGGFTFG GDGPSAPTGT ATPEDCDFGF DFLALDLTVP ATATIWAPFE RAAPLPAFSG
CPAVNGAPAQ PNTGTRRSSG GGAATTPRHS PTLPEPGGLS LELPLARRSV PDPVGAVPWR
PPQSALPPFS GSTTFSTTPS LPSTTLASST LDTVPSEGNH KPSTTAANSS ASTAAPGPPS
AALARECVVC SEGEAMAALV PCGHNLFCMD CAVRICGKSE PECPACRTPA TQAIHIFS
//
