ID D3ZA19_RAT Unreviewed; 758 AA.
AC D3ZA19;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 2.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Spermidine/spermine N1-acetyl transferase-like 1 {ECO:0000313|Ensembl:ENSRNOP00000034830.4};
GN Name=Satl1 {ECO:0000313|Ensembl:ENSRNOP00000034830.4,
GN ECO:0000313|RGD:1565932};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000034830.4, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000034830.4, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000034830.4,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0007829|PubMed:22673903}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
RN [3] {ECO:0000313|Ensembl:ENSRNOP00000034830.4}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000034830.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the acetyltransferase family.
CC {ECO:0000256|ARBA:ARBA00008694}.
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DR RefSeq; NP_001157015.1; NM_001163543.1.
DR AlphaFoldDB; D3ZA19; -.
DR SMR; D3ZA19; -.
DR STRING; 10116.ENSRNOP00000034830; -.
DR iPTMnet; D3ZA19; -.
DR PhosphoSitePlus; D3ZA19; -.
DR PaxDb; 10116-ENSRNOP00000034830; -.
DR Ensembl; ENSRNOT00000037149.6; ENSRNOP00000034830.4; ENSRNOG00000022476.6.
DR GeneID; 302325; -.
DR KEGG; rno:302325; -.
DR UCSC; RGD:1565932; rat.
DR AGR; RGD:1565932; -.
DR CTD; 340562; -.
DR RGD; 1565932; Satl1.
DR eggNOG; KOG3216; Eukaryota.
DR GeneTree; ENSGT00950000183121; -.
DR HOGENOM; CLU_432730_0_0_1; -.
DR InParanoid; D3ZA19; -.
DR OMA; GHPGMWQ; -.
DR OrthoDB; 722999at2759; -.
DR TreeFam; TF319736; -.
DR Proteomes; UP000002494; Chromosome X.
DR Bgee; ENSRNOG00000022476; Expressed in testis and 1 other cell type or tissue.
DR GO; GO:0004145; F:diamine N-acetyltransferase activity; IBA:GO_Central.
DR GO; GO:0019809; F:spermidine binding; IBA:GO_Central.
DR GO; GO:0032918; P:spermidine acetylation; IBA:GO_Central.
DR CDD; cd04301; NAT_SF; 1.
DR Gene3D; 3.40.630.30; -; 1.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR000182; GNAT_dom.
DR PANTHER; PTHR10545; DIAMINE N-ACETYLTRANSFERASE; 1.
DR PANTHER; PTHR10545:SF63; SPERMIDINE_SPERMINE N(1)-ACETYLTRANSFERASE-LIKE PROTEIN 1; 1.
DR Pfam; PF00583; Acetyltransf_1; 1.
DR SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR PROSITE; PS51186; GNAT; 1.
PE 1: Evidence at protein level;
KW Reference proteome {ECO:0000313|Proteomes:UP000002494}.
FT DOMAIN 592..753
FT /note="N-acetyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS51186"
FT REGION 1..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 480..582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..143
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 758 AA; 84820 MW; 5364517496A25791 CRC64;
MDPSGKNQSG MTQSGLSQPV MSPPGPGPYN MQQPGPSQPY TSQPSMNQPS TNKPGVTRPV
SCQLDINQPG LGQSNIKQSW TSTNQPGIYK TDLSQQSMRE SDPRQVGMKQ LNSSQPAAMN
QTGLWQPGPP TPNMKQINTW QWDPEYSGRG PPDMWQITQN NQGTKQSDTV QQDPSYAGQK
QPDTWKQDPG MKETDLWQWG PSPPSMRQTD AWQWDPDHPG SKQSNSWQPQ LNPSSPRQFN
LRQASPTDQG MKQSDMCQPG PSQQGNRQSS TGQQSPGQQC TRHSVTWQAG PSEEGKKLSG
AWQVGLNHSG MEQFNTCQTG FSQPYNMCQL GPSQSSMKEL DMWQSGSSQP DMKDLDVWQS
GTSQPGMKQM DPWQWNPNYL VKTQSDKWPP GPSPLDIRQL DSWQPGQSGM KYSDSGPWDP
SRPGMIHSDL WHPSLSQLGT RQFDTWPQNY NMPGVRQLYT WHPTPSYSST RQSEKWQIYP
GNTNMKQSDN WETVPRQSGT TQLGTNQLDT NQPDGTKSNQ GVKTHSVKSE PSPSKPELTG
SSLDTSQSDL SQLGISQPGK SQLEPGESSM SELSERQQGV TQSVRKKDSC AFYIRPAEPQ
DCPDILRLIK ELATYEGTQE KVSLTELDLF KDGFGEKPLF YCLVAEAPSK QAESGVKIIG
FAMYYFTYDP RIGKLLHLED FYITEDYQGL GIGADMLKKL SQIAINTGCS GMQFLVIIWN
QDSVEYYTRL GALDLSCEEG WHLFRFNMED LLELAEEE
//
