ID D3ZAS2_RAT Unreviewed; 1096 AA.
AC D3ZAS2;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 94.
DE SubName: Full=Small G protein signaling modulator 1 {ECO:0000313|Ensembl:ENSRNOP00000000898.7};
GN Name=Sgsm1 {ECO:0000313|Ensembl:ENSRNOP00000000898.7,
GN ECO:0000313|RGD:1308178};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000000898.7, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000000898.7, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000000898.7,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0007829|PubMed:22673903}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
RN [3] {ECO:0000313|Ensembl:ENSRNOP00000000898.7}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000000898.7};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RUTBC family.
CC {ECO:0000256|ARBA:ARBA00034124}.
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DR RefSeq; XP_017453793.1; XM_017598304.1.
DR AlphaFoldDB; D3ZAS2; -.
DR STRING; 10116.ENSRNOP00000000898; -.
DR iPTMnet; D3ZAS2; -.
DR PhosphoSitePlus; D3ZAS2; -.
DR PaxDb; 10116-ENSRNOP00000000898; -.
DR Ensembl; ENSRNOT00000000898.8; ENSRNOP00000000898.7; ENSRNOG00000000708.8.
DR GeneID; 288743; -.
DR AGR; RGD:1308178; -.
DR CTD; 129049; -.
DR RGD; 1308178; Sgsm1.
DR VEuPathDB; HostDB:ENSRNOG00000000708; -.
DR eggNOG; KOG1648; Eukaryota.
DR GeneTree; ENSGT00940000156871; -.
DR HOGENOM; CLU_006235_0_0_1; -.
DR InParanoid; D3ZAS2; -.
DR OrthoDB; 164430at2759; -.
DR Proteomes; UP000002494; Chromosome 12.
DR Bgee; ENSRNOG00000000708; Expressed in frontal cortex and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; ISO:RGD.
DR GO; GO:0005829; C:cytosol; ISO:RGD.
DR GO; GO:0005096; F:GTPase activator activity; ISO:RGD.
DR GO; GO:0031267; F:small GTPase binding; ISO:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR CDD; cd15784; PH_RUTBC; 1.
DR CDD; cd17703; RUN_SGSM1; 1.
DR Gene3D; 1.20.58.900; -; 1.
DR Gene3D; 2.30.29.230; -; 1.
DR Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR InterPro; IPR000195; Rab-GAP-TBC_dom.
DR InterPro; IPR035969; Rab-GAP_TBC_sf.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR047344; RUN_SGSM1.
DR InterPro; IPR037745; SGSM1/2.
DR InterPro; IPR021935; SGSM1/2_RBD.
DR PANTHER; PTHR22957:SF187; SMALL G PROTEIN SIGNALING MODULATOR 1; 1.
DR PANTHER; PTHR22957; TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF12068; PH_RBD; 1.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR Pfam; PF02759; RUN; 1.
DR SMART; SM00593; RUN; 1.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF140741; RUN domain-like; 1.
DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR PROSITE; PS50826; RUN; 1.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494}.
FT DOMAIN 36..190
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 565..1029
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000259|PROSITE:PS50086"
FT REGION 380..415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 648..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 817..841
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 84..118
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 650..683
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 686..700
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 705..743
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 818..835
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1096 AA; 123829 MW; 23CAFEF9B696923D CRC64;
MASVPAEAET RQRLLRTVKK EVKQIMEEAV TRKFVHEDSS HIISFCAAVE ACVLHGLRRR
AAGFLRSNKI AALFMKVGKG FPPAEELSRK VQELEQLIES ARNQIQGLQE NVRKLPKLPN
LSPLAIKHLW IRTALFERVL DKIVHYLVEN SSKYYEKEAL LMDPVDGPIL ASLLVGPCAL
EYTKMKTADH FWTDPSADEL VQRHRIHSSH LRQDSPTKRP ALCVRWIQKR HSSGSMDDRP
SISARDYVES LHQNSRATLL YGKNNVLVQP RDDMEAVPGY LSLHQTADVM TLKWTPNQLM
NGSVGDLDYE KSVYWDYAVT IRLEEIVYLH CHQQVDSGGT VVLVSQDGIQ RPPFRFPKGG
HLLQFLSCLE NGLLPHGQLD PPLWSQRGKG KVFPKLRKRS PQGSSESTSS DKEDDEATDY
VFRIIYPGTQ SEFVPQDLMD VSMNNLPSLW QPSPRKSSCS SCSQSGSADG SSTNGCNHER
APLKLLCDNM KYQILSRAFY GWLAYCRHLS TVRTHLSALV NHMIVSPDLP CDAGQGLTAS
IWEQYIQDST TYPEQELLRL IYYGGVQPEI RRAVWPFLLG HYQFGMTEME RKEVDEQIHA
CYAQTMSEWL GCEAIVRQRE RESHAAALAK CSSGASLDSH LHRMLHRDST ISNESSQSCS
SGRQNLRLQS DSSSSTQVFE SVDEVEQTEA EGRSEEKHPK IPNGNPANGT CSPDSGHPSS
HNFSSGLSEH SEPSLSTEDS VLDVQRSLPA VFRPGDSSVE DGQSSEATTS RDEAPREELA
VQDSLESDLL ANESLEEFMS IPGSLDVALP EKDGAMMDGW PGEADKHGRA DSEDNLSEEP
EMESLFPALA SLAVTSSANN ETSPVSSSGV TYSPELLDLY TVNLHRIEKD VQRCDRSYWY
FTAANLEKLR NIMCSYIWQH IEIGYVQGMC DLLAPLLVIL DDEALAFSCF TELMKRMNQN
FPHGGAMDTH FANMRSLIQI LDSELFELMH QNGDYTHFYF CYRWFLLDFK RELVYDDVFS
VWETIWAAKH VSSAHYVLFI ALALVEVYRD IILENNMDFT DIIKFFNEMA ERHNAKQILQ
LARDLVHKVQ ILIENK
//
