ID D3ZPL7_RAT Unreviewed; 2111 AA.
AC D3ZPL7;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 103.
DE SubName: Full=DS cell adhesion molecule-like 1 {ECO:0000313|Ensembl:ENSRNOP00000022476.4};
GN Name=Dscaml1 {ECO:0000313|Ensembl:ENSRNOP00000022476.4,
GN ECO:0000313|RGD:1304887};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000022476.4, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000022476.4, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000022476.4,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000022476.4}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000022476.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Synapse {ECO:0000256|ARBA:ARBA00034103}.
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DR RefSeq; NP_001101611.1; NM_001108141.1.
DR AlphaFoldDB; D3ZPL7; -.
DR SMR; D3ZPL7; -.
DR STRING; 10116.ENSRNOP00000022476; -.
DR PaxDb; 10116-ENSRNOP00000022476; -.
DR Ensembl; ENSRNOT00000022476.5; ENSRNOP00000022476.4; ENSRNOG00000016502.6.
DR GeneID; 315615; -.
DR KEGG; rno:315615; -.
DR UCSC; RGD:1304887; rat.
DR AGR; RGD:1304887; -.
DR CTD; 57453; -.
DR RGD; 1304887; Dscaml1.
DR eggNOG; KOG3510; Eukaryota.
DR GeneTree; ENSGT00940000155354; -.
DR HOGENOM; CLU_001038_0_1_1; -.
DR OMA; GHTMELP; -.
DR OrthoDB; 3427297at2759; -.
DR TreeFam; TF316846; -.
DR Reactome; R-RNO-376172; DSCAM interactions.
DR Proteomes; UP000002494; Chromosome 8.
DR Bgee; ENSRNOG00000016502; Expressed in frontal cortex and 1 other cell type or tissue.
DR GO; GO:0030424; C:axon; IBA:GO_Central.
DR GO; GO:0009986; C:cell surface; ISO:RGD.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0098632; F:cell-cell adhesion mediator activity; IBA:GO_Central.
DR GO; GO:0042803; F:protein homodimerization activity; ISO:RGD.
DR GO; GO:0007411; P:axon guidance; IBA:GO_Central.
DR GO; GO:0007420; P:brain development; ISO:RGD.
DR GO; GO:0070593; P:dendrite self-avoidance; ISO:RGD.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; ISO:RGD.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; ISO:RGD.
DR GO; GO:0007162; P:negative regulation of cell adhesion; ISO:RGD.
DR CDD; cd00063; FN3; 6.
DR CDD; cd00096; Ig; 2.
DR CDD; cd05734; Ig_DSCAM; 1.
DR CDD; cd05735; Ig_DSCAM; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 16.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR10075; BASIGIN RELATED; 1.
DR PANTHER; PTHR10075:SF14; DOWN SYNDROME CELL ADHESION MOLECULE 3, ISOFORM E-RELATED; 1.
DR Pfam; PF00041; fn3; 6.
DR Pfam; PF07679; I-set; 4.
DR Pfam; PF13927; Ig_3; 4.
DR SMART; SM00060; FN3; 6.
DR SMART; SM00409; IG; 10.
DR SMART; SM00408; IGc2; 9.
DR SMART; SM00406; IGv; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 10.
DR PROSITE; PS50853; FN3; 6.
DR PROSITE; PS50835; IG_LIKE; 9.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
SQ SEQUENCE 2111 AA; 230198 MW; 7FEDF3C3A1BEB26E CRC64;
MTGAGEPRRE EPPPCAGLRS RESGAPSAGG WERAERGRGA AARPATGPPP RRKGPLYGMW
LVTFLLLLDS LHKARPEDVG TSLYFVNDSL QHVTFSSSVG VVVPCPAAGS PSAALRWYLA
TGDDIYDVPH IRHVHANGTL QLYPFSPSAF NSFIHDNDYF CTAENAAGKI RSPNIRIKAV
FREPYTVRVE DQRSMRGNVA VFKCLIPSSV QEYVSVVSWE KDTVSITPEN RFFITSHGGL
YISDVQKEDA LSTYRCITQH KYSGETRQSN GARLSVTDPA ESIPTILDGF HSQEVWTGHA
VELPCAASGY PIPAIRWLKD GRPLPADSRW AKRITGLTIS DLRTEDSGTY ICEVTNTFGS
AEANGVLTVI DPLHVTLTPK KLKTGIGSTV ILSCALTGSP EFTIRWYRNT ELVLPGEAIS
IRGLSNETLL ISSAQKSHSG AYQCFATRKA QTAQDFAIIV LEDGTPRIVS SFSEKVVNPG
EQFSLMCAAK GAPPPTVTWA LDDEPVVRDG SHRTNQYTMS DGTTISHMNV TGPQIRDGGV
YRCTARNSVG SAEYQARINV RGPPSIRAMR NITAVAGRDT LINCRVIGYP YYSIKWYKDA
LLLPDNHRQV VFENGTLKLT DVQKGMDEGE YLCSVLIQPQ LSISQSVHVA VKVPPLIQPF
EFPPASIGQL LYIPCVVSSG DMPIRITWRK DGQVIISGSG VTIESKEFMS SLQISSVSLK
HNGNYTCIAS NAAATVSRER QLIVRVPPRF VVQPNNQDGI YGKAGVLNCS VDGYPPPKVM
WKHAKGSGNP QQYHPVPLTG RIQILPNSSL LIRHVLEEDI GYYLCQASNG VGTDISKAMF
LTVKIPAMIT SHPNTTIAIK GHAKELNCTA RGERPIIIRW EKGDTVIDPD RVMRYAIATK
DNGDEVVSTL KLKPADRGDS VFFSCHAINS YGEDRGLIQL TVQEPPDPPE LEIREVKARS
MNLRWTQRFD GNSIITGFDI EYKNKSDSWD FKQSTRNISP TINQANIVDL HPASVYSIRM
YSFNKIGRSE PSKELTISTE EAAPDGPPMD VTLQPVTSQS IQVTWKAPKK ELQNGIIRGY
QIGYRENSPG SNGQYSIVEM KATGDSEVYT LDNLKKFAQY GVVVQAFNRA GTGPSSSEIN
ATTLEDVPSQ PPENVRALSI TSDVAVISWS EPPRSTLNGV LKGYRVIFWS LYVDGEWGEM
QNVTTTRERV ELRGMEKFTN YSVQVLAYTQ AGDGVRSSVL YIQTKEDVPG PPAGIKAVPS
SASSVVVSWL PPTKPNGVIR KYTIFCSSPG SGQPAPSEYE TSPEQLFYRI AHLNRGQQYL
LWVAAVTSAG RGNSSEKVTI EPAGKAPAKI ISFGGTVTTP WLKDVRLPCN SVGDPAPAVK
WTKDSEDSAI PVSLDGHRLI HTNGTLLLRA VKAEDSGYYT CTATNTGGFD TIIVNLLVQV
PPDQPRLTVS KTSASSITLT WIPGDNGGSS IRGFVLQYSV DNSEEWKDVF ISSSERSFKL
DSLKCGTWYK VKLAAKNSVG SGRISEIIEA KTHGREPSFS KDQHLFTHIN STHARLNLQG
WNNGGCPITA IVLEYRPKGT WAWQGVRANS STEVFLTELR EATWYELRMR ACNSAGCGNE
TAQFATLDYD GSTIPPIKSA QGEGDDVKKL FTIGCPVILA TLGVALLFVV RKKRKEKRLK
RLRDAKSLAE MLISKNNRSF DTPVKGPPQG PRLHIDIPRV QLLIEDKEGI KQLGDDKATI
PVTDAEFSQA VNPQSFCTGV SLHHPALIQS TGPLIDMSDI RPGTNPVSRK NVKSAHSTRN
RYSSQWTLTK CQASTPARTL TSDWRTVGSQ HGVTVTESDS YSASLSQDTD KGRNSMVSTE
SASSTYEELA RAYEHAKLEE QLQHAKFEIT ECFISDSSSD QMTTGTNENA DSMTSMSTPS
EPGICRFTAS PPKPQDADRG KNVAVPIPHR ANKSDYCNLP LYTKSEAFFR KADGREPCPV
VPPREASMRN LTRAYHTQAR HLTLDPASKP LGLPHPGATA ATATATLPQR TLAMPAPPAG
TAPPAPGPTP SEPSAPPSAA PPAPSTEPPR AGGPHTKMGG SRDSLLEMST PGVGRSQKQG
AGAYSKSYTL V
//