ID D3ZSM9_RAT Unreviewed; 816 AA.
AC D3ZSM9;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 3.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=BRCA1-associated ATM activator 1 {ECO:0000313|Ensembl:ENSRNOP00000059762.3};
GN Name=Brat1 {ECO:0000313|Ensembl:ENSRNOP00000059762.3,
GN ECO:0000313|RGD:1565146};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000059762.3, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000059762.3, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000059762.3,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000059762.3}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000059762.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_003751181.1; XM_003751133.2.
DR RefSeq; XP_003752605.1; XM_003752557.2.
DR RefSeq; XP_006221330.1; XM_006221268.2.
DR RefSeq; XP_006249030.1; XM_006248968.2.
DR AlphaFoldDB; D3ZSM9; -.
DR STRING; 10116.ENSRNOP00000059762; -.
DR PhosphoSitePlus; D3ZSM9; -.
DR jPOST; D3ZSM9; -.
DR PaxDb; 10116-ENSRNOP00000059762; -.
DR PeptideAtlas; D3ZSM9; -.
DR Ensembl; ENSRNOT00000064726.4; ENSRNOP00000059762.3; ENSRNOG00000001236.8.
DR GeneID; 498150; -.
DR KEGG; rno:498150; -.
DR AGR; RGD:1565146; -.
DR CTD; 221927; -.
DR RGD; 1565146; Brat1.
DR eggNOG; ENOG502QRW9; Eukaryota.
DR GeneTree; ENSGT00390000017551; -.
DR HOGENOM; CLU_018926_1_0_1; -.
DR InParanoid; D3ZSM9; -.
DR OMA; IGCFRVQ; -.
DR OrthoDB; 3020587at2759; -.
DR Proteomes; UP000002494; Chromosome 12.
DR Bgee; ENSRNOG00000001236; Expressed in thymus and 19 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0006915; P:apoptotic process; ISO:RGD.
DR GO; GO:0016477; P:cell migration; ISO:RGD.
DR GO; GO:0008283; P:cell population proliferation; ISO:RGD.
DR GO; GO:0006974; P:DNA damage response; ISO:RGD.
DR GO; GO:0006006; P:glucose metabolic process; ISO:RGD.
DR GO; GO:0051646; P:mitochondrion localization; ISO:RGD.
DR GO; GO:0030307; P:positive regulation of cell growth; ISO:RGD.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; ISO:RGD.
DR GO; GO:0010212; P:response to ionizing radiation; ISO:RGD.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR038904; BRAT1.
DR InterPro; IPR000357; HEAT.
DR PANTHER; PTHR21331; BRCA1-ASSOCIATED ATM ACTIVATOR 1; 1.
DR PANTHER; PTHR21331:SF2; BRCA1-ASSOCIATED ATM ACTIVATOR 1; 1.
DR Pfam; PF02985; HEAT; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:D3ZSM9};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
SQ SEQUENCE 816 AA; 88476 MW; D1E4E6EADAB6F5B1 CRC64;
MDAECSRLLP ALCAVLADPR QLVADDTCLE KLLDWFKTVT EAEPSLQLLQ DHPCLMELLS
HVLKPQDVSP RVLSFALRLV GVFAAQEDCF QYLQQGELLL GLFGETGALS WAAWSIPSVR
SGWIQGLCSL AHHPSALHFL ADSGAVDTIF SLQGDPSLFV ASAASQLLVH ILALSMQGGA
PGSPVPEAVA WPVCAQKIMN HVEESLHSKA TPQVTQALNV LTTTFGRCHN PWTGVLWERL
SPPVARLFER DPIPATHSLM DLLLSVARSP VLNFAACGLW EMLAQTLSRL SPTQAGPLAL
GTLKLQHCPQ ELRTQAFRVL LQPLACILKA TTQAPGPPGL LDGTAGSLLT VDALLSSKSA
CVGLLCQTLA HLEELQMLPQ CPSPWPQVPL LQAAVTILRL SDGSADPSSS AGGRLCGALG
GCVRVQRAAL DFLGTLSLGT SPLELVLEVF AVLLKTLESP ESSPMVLKKA FQATLRWLQS
PHKTPSGSDL SPDALLFLGE LFPILQKRLC SPCWEVRDSA LEFLTHLIRD WGGQADFREA
LHSSEVPTLA RQLLQDPESY VRASAVGAAG QLSSQGLQAT PANQQGLLMD LMHILSTDSE
GFPRRAVLRV FTEWLRDGHA DVVRDTEWFV ATVLQAVSRD LDWEVRVQGL ELAQVFLIQA
MGQPRLHCPY TVGLPGATSS RPHLEFLQTL CRLPLFEFAF CALLDCDRPV AQKACDLLLF
LRDKTVSCSN PQEAGDSPNS ASVEAALQRW REGEQAQPLG DLEPEAMLAI LRSLDLEGLQ
GRLAKSSDHV EKSPQSLLQD MLATVGVLEE NEADCY
//
