ID D4A3L3_RAT Unreviewed; 599 AA.
AC D4A3L3;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 109.
DE SubName: Full=Multiple EGF-like-domains 9 {ECO:0000313|Ensembl:ENSRNOP00000007812.4};
GN Name=Megf9 {ECO:0000313|Ensembl:ENSRNOP00000007812.4,
GN ECO:0000313|RGD:1308330};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000007812.4, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000007812.4, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000007812.4,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000007812.4}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000007812.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR RefSeq; NP_001101410.1; NM_001107940.1.
DR AlphaFoldDB; D4A3L3; -.
DR SMR; D4A3L3; -.
DR STRING; 10116.ENSRNOP00000007812; -.
DR PaxDb; 10116-ENSRNOP00000007812; -.
DR Ensembl; ENSRNOT00000007812.5; ENSRNOP00000007812.4; ENSRNOG00000005932.5.
DR GeneID; 313270; -.
DR KEGG; rno:313270; -.
DR UCSC; RGD:1308330; rat.
DR AGR; RGD:1308330; -.
DR CTD; 1955; -.
DR RGD; 1308330; Megf9.
DR eggNOG; KOG0994; Eukaryota.
DR GeneTree; ENSGT00940000161177; -.
DR HOGENOM; CLU_031674_2_0_1; -.
DR OMA; YIGPNCN; -.
DR OrthoDB; 5491831at2759; -.
DR Proteomes; UP000002494; Chromosome 5.
DR Bgee; ENSRNOG00000005932; Expressed in frontal cortex and 18 other cell types or tissues.
DR GO; GO:0005604; C:basement membrane; ISO:RGD.
DR GO; GO:0005201; F:extracellular matrix structural constituent; IBA:GO_Central.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0007411; P:axon guidance; IBA:GO_Central.
DR GO; GO:0009888; P:tissue development; IBA:GO_Central.
DR CDD; cd00055; EGF_Lam; 5.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR10574:SF444; -; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00053; Laminin_EGF; 5.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00180; EGF_Lam; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS01248; EGF_LAM_1; 3.
DR PROSITE; PS50027; EGF_LAM_2; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DISULFID 223..232
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 251..263
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 271..280
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 317..326
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 329..343
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 422..431
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 599 AA; 62886 MW; 5731C23822ACFBA2 CRC64;
MNGGAERAMR SLPSLGGLAL FCCAAAAAAS AASAGNVTGG GGAEGQVVAS PSPGLREQTS
SPFSKAAAPT AQAPRTGPPR TTVHRTGAAT PSAGSPETIP VRTSAQPAAT LFPVVDLSSA
TPSEDGHTPT TEPLPSRPAP TTLASTAGQA PTTSVVTTAQ ASSTPGTPTA ESPDRGRNSS
RVPPTAPVTE APTPPPPEYM CNCSEVGSLD VKRCNQTTGQ CDCHVGYQGL HCDTCKEGFY
LNHTVGLCLP CHCSPRGAVS ILCNSSGNCQ CKLGVTGSMC DQCQDGHYGF GKTGCLPCQC
NNRSDSCDVL TGACLNCQEN TKGEHCEECK EGFYQSPDAA RECLRCPCSA VTSTGNCTIE
FGALEPTCDQ CKDGYTGQNC NTCENGYYHS DSICLQCECH GHVDPIKTPK ICKPESGECI
NCLHNTTGLW CEKCLEGYVR DLQRNCIKQE VIVPTPEGST ILVSNASLTT SVPTPVINST
FAPTTLQTIF SVSSSENSTS ALADVSWTQF NIIILTVIII VVVLLMGFVG AVYMYREYQN
RKLNAPFWTI ELKEDNISFS SYHDSIPNAD VSGLLEDDAN EVAPNGQLTL TTPIHNYKA
//
