ID D4A987_RAT Unreviewed; 1428 AA.
AC D4A987;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE SubName: Full=Rho GTPase activating protein 31 {ECO:0000313|Ensembl:ENSRNOP00000004138.4};
GN Name=Arhgap31 {ECO:0000313|Ensembl:ENSRNOP00000004138.4,
GN ECO:0000313|RGD:1306093};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000004138.4, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000004138.4, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000004138.4,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0007829|PubMed:22673903}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
RN [3] {ECO:0000313|Ensembl:ENSRNOP00000004138.4}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000004138.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; NP_001099349.1; NM_001105879.1.
DR AlphaFoldDB; D4A987; -.
DR SMR; D4A987; -.
DR STRING; 10116.ENSRNOP00000004138; -.
DR PhosphoSitePlus; D4A987; -.
DR PaxDb; 10116-ENSRNOP00000004138; -.
DR Ensembl; ENSRNOT00000004138.6; ENSRNOP00000004138.4; ENSRNOG00000003088.7.
DR GeneID; 288093; -.
DR KEGG; rno:288093; -.
DR UCSC; RGD:1306093; rat.
DR AGR; RGD:1306093; -.
DR CTD; 57514; -.
DR RGD; 1306093; Arhgap31.
DR eggNOG; KOG1449; Eukaryota.
DR GeneTree; ENSGT00940000159458; -.
DR HOGENOM; CLU_006917_0_0_1; -.
DR OMA; TVMSLWT; -.
DR OrthoDB; 5308605at2759; -.
DR TreeFam; TF351451; -.
DR Reactome; R-RNO-8980692; RHOA GTPase cycle.
DR Reactome; R-RNO-9013148; CDC42 GTPase cycle.
DR Reactome; R-RNO-9013149; RAC1 GTPase cycle.
DR Reactome; R-RNO-9013420; RHOU GTPase cycle.
DR Proteomes; UP000002494; Chromosome 11.
DR Bgee; ENSRNOG00000003088; Expressed in lung and 18 other cell types or tissues.
DR GO; GO:0030027; C:lamellipodium; ISO:RGD.
DR GO; GO:0005096; F:GTPase activator activity; ISO:RGD.
DR GO; GO:0017124; F:SH3 domain binding; ISO:RGD.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; ISO:RGD.
DR CDD; cd04384; RhoGAP_CdGAP; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR15729; CDC42 GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15729:SF3; RHO GTPASE-ACTIVATING PROTEIN 31; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 1: Evidence at protein level;
KW Reference proteome {ECO:0000313|Proteomes:UP000002494}.
SQ SEQUENCE 1428 AA; 155457 MW; 708629E582A4C1B9 CRC64;
MKNKGAKQKL KRKGAASAFG CDLTEYLESS GQDVPYVLKS CAEFIETHGI VDGIYRLSGV
TSNIQRLRQE FGSDQCPDLT REVYLQDIHC VGSLCKLYFR ELPNPLLTYE LYEKFTEAVS
HCPEEGQLAR IQNVIQELPP PHYRTLEYLI RHLAHIASFS SKTNMHARNL ALVWAPNLLR
SKKIEATICN GDAAFLAVRV QQVVIEFILN HADQIFNGGA PGALQQDESR TITKSLTLPA
LSLPMKLVSL EEAQARSLAT NHPARKERRE NSLPEIVPSM GTPFHTVLEL PDNKRKLSSK
SKKWKSIFNL GRSGSDSKSK LSRNGSVFVR GQRLSVEKAT IRPAKSMDSL CSVPVEGKEN
KGNFNRTVTT GGFFIPATKM HASSTGSSCD LSKEGEWSQE GMPAGAEGGC EVGGQIRPLP
EQLKVFRPIG DPESEQSAPK LLGMFYTSSD SPGKSVFTSS LFQMEPSPRH QRKALNISEP
FAVSVPLRVS AVISTNSTPC RTPPKELQSL SSLEEFSFQG SESGGWPEEE KPLGAEPFPG
SVPKKAATED TKPEHEAPGR AECNQSLPLD PGTPLEKKTL DISLGSQLSK EPEKWPNAEK
AMEESQGASQ TKLSTPQESP RARTKPVLLH EMDEDDLAQA LIWPEIQQEL KIIESEEEFS
SLPPPAQKTS PMTESSPAPF PSPEAPESLP SSSAPLEVWT RDSANQSIQE TAILTNREKL
EPVCSLLESE SEQAVSPDPS TLAPLEILLF EKVSSPARIE IGGPGNLSPP LPPAPPPPTP
LEEEPQVLLS HEGPDREDAS RDSRTDLYTE QPNSEDSPGI PRLCQREEAI ASPNEKQDAK
QAVPESKDPG LPSPTKEVEV IPQEEGDASH SAQEPSDCDE DDTVIDTAQH GLEMVEPWEE
PQWVTSPLHS PTLKEIQESQ TQGSQGHRLE RRLRHRPSLR QSHSLDSKTT GQSHWALEAP
FSSSCASLET ERNYEPLQTP SARIKIAGLE EKALKAFREF SGLKGLEVLP SQKGSSGIQP
KPVETNFISL TEGKEQGPQL EFSNPQIKHN DVPGPDSSEG SSPGAQDSTS PGEHPLKLQL
KSTECGPSKG KHRPSSLNLD SAIPIADLFR VENGASFSSP GIELSELGDT KVIWMSSSQG
KAAPWSSQDT QDLGIVAHAL TGRRNSAPVS VSAVRTSFMV KMCQAKAVPV IPPKIQYTQI
PQPLPSQNTG EGGAQPPERN QEEPGSTPET PQKPTKDDSP SSLGSPEEEQ PKQEQGASAS
RRKASTTSCV AEGSFCSAEP GPSTLVSSQD AMGQCRKRTS ETEPSEDNLL SSKLERASGG
PKPTHRPRPG RPQSLILFPI MDHLPSSPTV IDSKVLLSPI RSPSQTVSPG LLCGELAENT
WVTPEGVTLR NKMTIPKNGQ RLETSTSCFY QPQRRSVILD GRSGRQIE
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