ID D4AAG8_RAT Unreviewed; 1567 AA.
AC D4AAG8;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 99.
DE SubName: Full=Structural maintenance of chromosomes flexible hinge domain containing 1 {ECO:0000313|Ensembl:ENSRNOP00000019359.7};
GN Name=Smchd1 {ECO:0000313|Ensembl:ENSRNOP00000019359.7,
GN ECO:0000313|RGD:1307234};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000019359.7, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000019359.7, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000019359.7,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000019359.7}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000019359.7};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; D4AAG8; -.
DR STRING; 10116.ENSRNOP00000019359; -.
DR jPOST; D4AAG8; -.
DR PaxDb; 10116-ENSRNOP00000019359; -.
DR PeptideAtlas; D4AAG8; -.
DR Ensembl; ENSRNOT00000019359.8; ENSRNOP00000019359.7; ENSRNOG00000014319.8.
DR UCSC; RGD:1307234; rat.
DR AGR; RGD:1307234; -.
DR RGD; 1307234; Smchd1.
DR VEuPathDB; HostDB:ENSRNOG00000014319; -.
DR eggNOG; ENOG502QREW; Eukaryota.
DR GeneTree; ENSGT00390000006950; -.
DR HOGENOM; CLU_002288_1_0_1; -.
DR InParanoid; D4AAG8; -.
DR OMA; PRGEHIM; -.
DR TreeFam; TF329426; -.
DR Proteomes; UP000002494; Chromosome 9.
DR Bgee; ENSRNOG00000014319; Expressed in spleen and 18 other cell types or tissues.
DR Genevisible; D4AAG8; RN.
DR GO; GO:0001740; C:Barr body; ISO:RGD.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:Ensembl.
DR GO; GO:0035861; C:site of double-strand break; ISO:RGD.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; ISO:RGD.
DR GO; GO:0042803; F:protein homodimerization activity; ISO:RGD.
DR GO; GO:0051276; P:chromosome organization; IEA:InterPro.
DR GO; GO:0010424; P:DNA methylation on cytosine within a CG sequence; ISO:RGD.
DR GO; GO:0009048; P:dosage compensation by inactivation of X chromosome; ISO:RGD.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR GO; GO:0060818; P:inactivation of paternal X chromosome by genomic imprinting; ISO:RGD.
DR GO; GO:2000042; P:negative regulation of double-strand break repair via homologous recombination; ISO:RGD.
DR GO; GO:0043584; P:nose development; ISO:RGD.
DR GO; GO:0045739; P:positive regulation of DNA repair; ISO:RGD.
DR GO; GO:2001034; P:positive regulation of double-strand break repair via nonhomologous end joining; ISO:RGD.
DR Gene3D; 1.20.1060.20; -; 1.
DR Gene3D; 3.30.70.1620; -; 1.
DR InterPro; IPR010935; SMC_hinge.
DR InterPro; IPR036277; SMC_hinge_sf.
DR InterPro; IPR038892; SMCHD1.
DR PANTHER; PTHR22640:SF2; STRUCTURAL MAINTENANCE OF CHROMOSOMES FLEXIBLE HINGE DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR22640; UNCHARACTERIZED; 1.
DR Pfam; PF06470; SMC_hinge; 1.
DR SMART; SM00968; SMC_hinge; 1.
DR SUPFAM; SSF75553; Smc hinge domain; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002494}.
FT DOMAIN 1289..1416
FT /note="SMC hinge"
FT /evidence="ECO:0000259|SMART:SM00968"
SQ SEQUENCE 1567 AA; 176895 MW; 04B69D3A13707837 CRC64;
MRRNSLSLYL RNIKNNLILH FRHIYHYYIH GPKGNEISTA KDISLFEKGK TPKIVNLREI
QDDMQTLYIN TASDSFEFKA HVEGDGVVEE TYPDDPCFPS KLRDEDDDDD CFIPEKAARG
KRPIFECFLE WTRACPIECF NRISGALFTN DKFQVSTNKL TFMDLELKLK DKNTLFTRIL
NGQEQRMKID REFALWLKDC HENKKQGPWA TFSAIEWDGK IYKAGQLVKT IKTLPLFYGS
IVRFFLHGDH DGEVYATGGE VQIAMVRKQI KKKLPDRLSV TWPEGDELVP NEVRPAGTPI
GALRIEILNK KGEAMQKLPG TSHGGSKKLL VELKVILHTS SGNKEIISHI SQHGGKWPYW
FKKMENIQKL GNYTLKLQVV LNESNADTYA GRSLPSKAIK FSVKEGKPEK FSFGLLDSPF
RVGVPFNIPL EFQDEFGHTT QLLSDIQPVL EASGLSLHYE EITKGPNCVI QGVIAKGPVN
SCQGKNFNLK VILPGLKEDS QILKIRLLPG PPHRLKVKPD SEILVIENGT AFPFQVEVVD
ESDNITAQPK LIVHCKFLGA PNLPVYTVDC SSSGTSILTG SPIQVQNIKK DQTLTARIEI
PSCKDVSPVE KTIKLLPSSH VACLQIFSVE GQKAIQIKHQ DEVNWIAGDV MRNLIFQMYD
EGEREINITP SLAEKIKVNW TPEVNKEHLV QGLLPDVQVP TSVKDVRYCQ VSFQDDHVSL
ESAFTVRSVN LLTSSNIFRL IVIIVDQYGN QISAFSSDSL STLSISGDGL DSKNLKTTLE
TSTQSISVQG IRFTPGPPGP KDLCFTWREF SDFIRVHLIS GPPTKLLLID WPELKESIPV
INGRQLQNPL IVQLCDQWDN PALVPNVKIC LIKASSLKLV PSNQQHKTDD KGRANLGMFT
VFAPRGEHTV QVKGVYNKST IEGPTIKLMI LPDPEKPIRL NVKYDKDASF IAGDIFTDFM
VSVISEGGSV IKNINPTRIS MKMWKLSSGM SRPPANAEIF SCNKIKDNDK EDGCFYFREK
TIPCKVGAYC IQFDFMIDKT NMLSSEQVIV DVLPNQPMKL VPDTQPATPA VSNVRSIASR
TLVKDLRLSI TDNYGNHTGM DLVGTVVATI KGFNEEDTDT PLFIGKVRTL EFPFVNGSAE
ITTLVLAENS PGRDSTEYFI IFEPRLSTLS STLESYSLPF MFYNDVKKQQ QMAALTKEKD
ELSKSITMYR SLFDANKQLL DEMKCQAEEA KFKETQLRNE LKAHNIDIPA TQQIPHIEAL
LEKKIAEQNE LKKRPRRLCT LPNYTKRSGD ILGKIAHLAQ IEDDRAAMVI SWHLASDMDC
VVTLTTDAAR CIYDETQGRQ QVLPLDSIYR KTLPDWKRPL PHFRNGKLHF KPFGDPVFAR
DLLTFPDNIE HCETVFGMLL GDTIILDNLD AANHYRKEVV KITHCPTLLT RDGDRIRSNG
KFGGLQNKAP PMDKLRGMVF GAPVPKQCVD LGKQIDLIQQ YRNALCKLNS VRADLDHQLQ
YLHTPDMKRK KQELDEQEKS LKRIEQKLGM TPMRRCSDSL CLSPKIEVTE CPIPTKRMRR
ESIRQNR
//